【摘要】：目的:通過研究早產(chǎn)兒腦損傷的高危因素,避免高危因素的發(fā)生,從而降低早產(chǎn)兒腦損傷的發(fā)病率,改善早產(chǎn)兒的預(yù)后,提高其生活質(zhì)量。方法:研究近3年來新生兒科住院早產(chǎn)兒的頭顱磁共振成像檢查,根據(jù)頭顱MRI結(jié)果將有異常表現(xiàn)的設(shè)為早產(chǎn)兒腦損傷組,無異常為對照組。其中腦損傷組又分為單純?nèi)毖跞毖該p傷組,單純出血性損傷組,以及兩者混合性損傷組。詳細(xì)統(tǒng)計(jì)臨床資料,通過對相關(guān)因素分析,行Logistic回歸分析統(tǒng)計(jì)學(xué)方法,篩選出與早產(chǎn)兒腦損傷有關(guān)的危險(xiǎn)因素,以及不同腦損傷組的危險(xiǎn)因素。結(jié)果:1.納入調(diào)查范圍內(nèi)的早產(chǎn)兒共229例,其中診斷為早產(chǎn)兒腦損傷85例;對照組144例。早產(chǎn)兒腦損傷組中單純?nèi)毖跞毖該p傷21例,單純出血性損傷52例,兩者混合性損傷12例。2.通過Logistic回歸分析提示:(1)胎齡、胎膜早破、分娩方式、BE、機(jī)械通氣、新生兒感染與早產(chǎn)兒腦損傷的發(fā)生有關(guān),有統(tǒng)計(jì)學(xué)意義(p0.05);其中小胎齡、低BE值為危險(xiǎn)因素。(2)單純?nèi)毖跞毖該p傷組:低BE值、新生兒感染為危險(xiǎn)因素;單純出血性損傷組:新生兒感染、胎膜早破、機(jī)械通氣為危險(xiǎn)因素;混合性腦損傷組:機(jī)械通氣為危險(xiǎn)因素。結(jié)論:1.早產(chǎn)兒腦損傷是多種因素相互作用的結(jié)果,其發(fā)病基礎(chǔ)是早產(chǎn)兒發(fā)育的不成熟和易感性。2.小胎齡、胎膜早破、低BE值、機(jī)械通氣、新生兒感染是早產(chǎn)兒腦損傷的危險(xiǎn)因素。
[Abstract]:Objective: to study the high risk factors of brain injury in premature infants, to avoid the occurrence of high risk factors, to reduce the incidence of brain injury in preterm infants, to improve the prognosis of premature infants and to improve their quality of life. Methods: the cranial magnetic resonance imaging of premature infants in recent 3 years was studied. According to the results of cranial MRI, the abnormal findings were divided into premature infants with brain injury group and no abnormal group as control group. The brain injury group was divided into simple hypoxic-ischemic injury group, hemorrhagic injury group, and mixed injury group. The clinical data were analyzed in detail and the risk factors related to brain injury of premature infants and different brain injury groups were screened by Logistic regression analysis. The result is 1: 1. A total of 229 premature infants were included in the study, including 85 cases of brain injury diagnosed as premature infants and 144 cases of control group. There were 21 cases of pure hypoxic-ischemic injury, 52 cases of hemorrhagic injury and 12 cases of mixed injury. Logistic regression analysis showed that: (1) gestational age, premature rupture of membranes, mode of delivery, BE, mechanical ventilation and neonatal infection were associated with brain injury in premature infants (p0.05); Among them, small gestational age, low BE value is the risk factor. (2) simple hypoxic-ischemic injury group: low BE value, neonatal infection as a risk factor, hemorrhagic injury group: neonatal infection, premature rupture of fetal membranes, mechanical ventilation as a risk factor; Mixed brain injury group: mechanical ventilation was the risk factor. Conclusion: 1. Brain injury in premature infants is the result of the interaction of many factors, and its pathogenesis is based on premature infants' immature development and susceptibility. 2. Small gestational age, premature rupture of membranes, low BE, mechanical ventilation and neonatal infection were risk factors of brain injury in premature infants.
【學(xué)位授予單位】：皖南醫(yī)學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R722.6

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 徐鳳丹;封志純;孔祥永;張珊;吳鴻雁;段順艷;童笑梅;劉少君;劉子源;呂紅艷;楊李紅;吳素靜;巨容;汪瑾;彭立;李占魁;趙小林;曾淑娟;丘惠嫻;溫偉溪;武輝;李瑩;李楠;賈文崢;張雪峰;郭果;劉衛(wèi)鵬;王鳳;李改梅;劉芳;李薇;趙曉英;程紅斌;許云波;陳文超;尹歡;丁艷潔;王曉亮;單瑞艷;許平;韓梅盈;楊春燕;;住院分娩早產(chǎn)兒呼吸窘迫綜合征:中國13家醫(yī)院的回顧性調(diào)查[J];中華圍產(chǎn)醫(yī)學(xué)雜志;2016年10期

2 馮曉霞;宋紅;宋煥清;李倩;劉園園;周川;;神經(jīng)生長因子治療早產(chǎn)兒腦病的療效觀察[J];中國實(shí)用神經(jīng)疾病雜志;2016年10期

3 王俊怡;虞人杰;劉淑芳;徐小靜;劉霞;朱建宏;李莉娜;楊傳忠;朱小瑜;岳少杰;張巍;馬建榮;曹云;王來栓;葉鴻瑁;童笑梅;張雪峰;李云珠;李龍;王丹華;萬偉琳;;新生兒臍動(dòng)脈血?dú)夥治鲈谛律鷥褐舷⒍嗥鞴贀p害診斷中的應(yīng)用[J];中國新生兒科雜志;2016年02期

4 余琳;蘇日娜;魏玉梅;王晨;楊慧霞;;系統(tǒng)整群抽樣調(diào)查分析北京地區(qū)15家醫(yī)院經(jīng)產(chǎn)婦的臨床特征[J];中華圍產(chǎn)醫(yī)學(xué)雜志;2016年02期

5 徐發(fā)林;程慧清;高亮;王彩紅;段佳佳;;早產(chǎn)兒早期凝血功能與胎齡的關(guān)系[J];臨床兒科雜志;2016年01期

6 關(guān)楚翹;吳東亮;;重度妊娠高血壓病對早產(chǎn)兒白細(xì)胞及凝血功能影響的研究[J];臨床和實(shí)驗(yàn)醫(yī)學(xué)雜志;2015年14期

7 賈系群;劉翠青;夏耀方;馬莉;;振幅整合腦電圖在新生兒缺氧缺血性腦病早期診斷及預(yù)后評估中的意義[J];中華實(shí)用兒科臨床雜志;2015年14期

8 李冰;張茜;時(shí)贊揚(yáng);程欣茹;;早產(chǎn)兒顱內(nèi)出血繼發(fā)梗阻性腦積水相關(guān)因素分析[J];臨床兒科雜志;2015年04期

9 毛健;;早產(chǎn)兒腦白質(zhì)損傷磁共振成像診斷基礎(chǔ)與評價(jià)[J];臨床兒科雜志;2015年03期

10 何偉儀;施純媛;汪良兵;柳國勝;;早產(chǎn)兒腦損傷和腦發(fā)育的臨床及MRI分析[J];暨南大學(xué)學(xué)報(bào)(自然科學(xué)與醫(yī)學(xué)版);2015年01期

，

本文編號：2337883