發(fā)布時(shí)間：2018-03-14 03:35

  本文選題：口蹄疫病毒　切入點(diǎn)：S粒子　出處：《中國(guó)獸藥雜志》2017年07期 　論文類型：期刊論文

【摘要】：口蹄疫是一種感染牛、羊和豬等偶蹄動(dòng)物、具有高度傳染性的動(dòng)物疫病。疫苗免疫是控制該病的關(guān)鍵措施之一,口蹄疫滅活疫苗在口蹄疫流行地區(qū)廣泛使用。滅活疫苗中,完整口蹄疫病毒粒子(146S粒子)是至關(guān)重要的免疫抗原,它的數(shù)量和穩(wěn)定性決定了疫苗的免疫效果。不同血清型,甚至同型不同毒株的口蹄疫病毒粒子穩(wěn)定性不同,146S粒子在一定溫度、酸、堿條件下容易分解為五聚體(12S粒子),導(dǎo)致疫苗免疫效力大幅下降。近年來(lái)口蹄疫病毒結(jié)構(gòu)及其穩(wěn)定性的分子基礎(chǔ)研究取得了新進(jìn)展,為研究口蹄疫病毒穩(wěn)定性提高疫苗質(zhì)量,開(kāi)發(fā)新型口蹄疫空衣殼疫苗提供了重要理論基礎(chǔ)。本文簡(jiǎn)要介紹了口蹄疫病毒結(jié)構(gòu)基礎(chǔ)、穩(wěn)定性研究方法和研究進(jìn)展,為了解口蹄疫病毒結(jié)構(gòu)與免疫的關(guān)系,評(píng)價(jià)新型疫苗提供參考信息。
[Abstract]:Foot and mouth disease is an infection of cattle, sheep and pigs and other cloven hoofed animal, animal disease is highly contagious. Vaccination is one of the key measures to control the disease, foot-and-mouth disease inactivated vaccine is widely used in the foot-and-mouth disease epidemic area. Inactivated vaccine against foot-and-mouth disease virus, complete particle (146S particles) is a vital immune antigen the number and stability of it determines the immune effect of the vaccine. Different serotypes, and even the stability of foot-and-mouth disease virus particles of different strains of different 146S particles at a certain temperature, acid and alkali conditions easily decomposed into five dimers (12S particles), leading to vaccine in recent years has dropped significantly. Progress in study of the molecular basis of foot-and-mouth disease virus and its stability, improve the quality of the vaccine of foot-and-mouth disease virus stability, development of new foot-and-mouth disease vaccine empty capsid provides an important theoretical basis of this paper briefly. The structure foundation, stability research methods and research progress of foot-and-mouth disease virus were introduced, providing reference information for understanding the relationship between FMDV structure and immunity, and evaluating new vaccine.

【作者單位】： 中國(guó)獸醫(yī)藥品監(jiān)察所;
【基金】：農(nóng)業(yè)部公益性行業(yè)(農(nóng)業(yè))科研專項(xiàng)"動(dòng)物疫苗制劑及下游工藝技術(shù)研究與示范"(P2015003086)
【分類號(hào)】：S859.797

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本文編號(hào)：1609423