本文選題：豬 + 急性亞段肺動脈栓塞��； 參考：《南京醫(yī)科大學》2006年碩士論文

【摘要】：目的：1．運用介入栓塞技術(shù)建立一種能用于影像學診斷的豬急性亞段肺動脈栓塞模型，并評價其技術(shù)上的可行性和準確性；2．比較多層螺旋CT肺動脈造影不同層厚對亞段肺動脈栓塞的顯示能力；3．以肺動脈血管鑄型標本為金標準，比較多層螺旋CT肺動脈造影、數(shù)字減影X線肺動脈造影對亞段肺動脈栓塞的顯示能力。 方法：1．5只家豬經(jīng)右側(cè)頸外靜脈注入若干聚氯乙烯(PVC)栓塞劑(直徑2-3mm)，栓塞前后分別做DSPA和CTPA。栓塞成功后24小時內(nèi)處死動物，取出完整豬肺組織。經(jīng)肺動脈主干注入適量鑄型劑(32.8％樹脂溶液)行血管鑄型；2．5只家豬，均用1.0mm準直掃描進行CT肺動脈造影，分別用1.0mm／0.5mm(層厚／層間距)(A組)，2.0mm／1.0mm(B組)，，3.0mm／1.5mm(C組)重建，記錄每只家豬3種不同重建層厚顯示亞段肺動脈栓塞的敏感性和陽性預測值；3．5只家豬，分別進行數(shù)字減影X線肺動脈造影、多層螺旋CT肺動脈造影和肺動脈血管鑄型，多層螺旋CT肺動脈造影圖像分別用1mm、2mm、3mm層厚重建，記錄每只家豬3種不同方法檢測亞段肺動脈栓子的敏感性和陽性預測值。 結(jié)果：1．5只豬全部成功制作急性亞段肺動脈栓塞模型，在DSPA圖像上，亞段肺動脈栓塞表現(xiàn)為相應區(qū)域的肺動脈分支數(shù)減少；在CTPA
[Abstract]:Objective: 1. to establish a model of acute subsegmental pulmonary embolism that can be used for imaging diagnosis by interventional embolization, and to evaluate its technical feasibility and accuracy; 2. compare the ability to display subsegmental pulmonary embolism with different thickness of multi slice spiral CT pulmonary arteriography, and 3. with pulmonary artery vascular cast specimen as gold standard. Comparison of multislice spiral CT pulmonary angiography and digital subtraction pulmonary angiography in demonstrating the ability of subsegmental pulmonary embolism.
Methods: 1.5 domestic pigs were injected with a number of polyvinyl chloride (PVC) embolic agents (diameter 2-3mm) through the right external jugular vein. The animals were killed within 24 hours after embolization with DSPA and CTPA. respectively. The whole lung tissue was taken out. A proper amount of mould agent (32.8% tree fat solution) was injected into the main trunk of the pulmonary artery, and 2.5 domestic pigs were treated with 1.0mm. CT pulmonary angiography was performed by collimated scanning, and the sensitivity and positive predictive value of 3 different reconstructive layer thickness of each pig were recorded with 1.0mm / 0.5mm (layer thickness / interval) (group A), 2.0mm / 1.0mm (group B), 3.0mm / 1.5mm (C group), and 3.5 domestic pigs, respectively, with digital subtraction X-ray pulmonary angiography and multi layer snail, respectively. Spiral CT pulmonary angiography and pulmonary artery cast, multi-slice spiral CT pulmonary angiography images were reconstructed with 1mm, 2mm, 3mm thickness respectively. The sensitivity and positive predictive value of 3 different methods for detecting subsegmental pulmonary emboli were recorded in each pig.
Results: all 1.5 pigs successfully made an acute subsegmental pulmonary embolism model. In the DSPA image, the number of pulmonary artery branches in the corresponding region was reduced by subsegmental pulmonary artery embolization; in CTPA

【學位授予單位】：南京醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2006
【分類號】：R-332;R816.4

【參考文獻】

相關(guān)期刊論文 前2條

1 吳春根,周康榮,湯敏,嚴福華,曾蒙蘇,王佩芬;心電標記回顧性肺動脈多層螺旋CT血管造影術(shù)(附5例肺動脈栓塞)[J];臨床放射學雜志;2003年04期

2 于麗娟,張雪林,李任飛,劉瑞寶,欒玉,王丹,申寶忠;家兔急性肺栓塞影像模型的制備[J];中國臨床醫(yī)學影像雜志;2004年03期

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