慢性疼痛（chronic pain,CP）通常是指在傷病愈合后仍持續(xù)并超過三個月的疼痛。其發(fā)生率較高,給患者個人及其家庭造成重大的身心和經(jīng)濟負擔,并對社會健康系統(tǒng)產(chǎn)生消極影響。研究者已經(jīng)對慢性疼痛的發(fā)生和維持機制進行了廣泛關(guān)注。其中,恐懼回避模型（fear-avoidance model）強調(diào)了疼痛恐懼（fear of pain,FOP）在慢性疼痛的發(fā)生和維持過程中起著重要作用。疼痛恐懼是指對疼痛進行負面解釋,即把疼痛等同于傷害,認為疼痛是災難性的,導致在預期疼痛或體驗疼痛時產(chǎn)生過度緊張、恐懼的情緒反應。疼痛恐懼可以通過直接經(jīng)驗、言語威脅信息和觀察學習等途徑獲得,并且可以泛化到與原始恐懼相關(guān)的刺激或情境類似的新的刺激或情境中。目前已經(jīng)有許多研究,采用行為指標（例如反應時和眼球運動）,在健康和臨床樣本中證明了較高的恐懼-回避相關(guān)信念和面對傷害性刺激時較差的功能反應存在很高的相關(guān)。但是,對疼痛恐懼潛在的認知神經(jīng)基礎的研究還相對較少,結(jié)果也存在不一致。此外,從動機的角度來看沖突情境中或者延遲情境下高疼痛恐懼個體的回避行為,可能會對恐懼回避模型有進一步的認識。研究1和研究2通過測量健康個體暴露... 

【文章來源】：西南大學重慶市 211工程院校 教育部直屬院校

【文章頁數(shù)】：188 頁

【學位級別】：博士

【文章目錄】：
摘要
ABSTRACT
1 LITERATURE REVIEW
    1.1 PAIN AND CHRONIC PAIN
    1.2 FEAR OF PAIN
    1.3 THE THEORY RELATED TO FOP
    1.4 FORMULATION OF HYPOTHESIS
    1.5 IMPORTANCE AND INNOVATIONS
2 STUDY1 FEAR OF PAIN AND EVENT-RELATED POTENTIALS DURING EXPOSURE TO IMAGE-CUED SENSORY STIMULATION
    2.1 INTRODUCTION
    2.2 MATERIAL AND METHODS
    2.3 RESULTS
    2.4 DISCUSSION
    2.5 CONCLUSIONS
3 STUDY2 EFFECTS OF TRAIT FEAR OF PAIN ON EVENT-RELATED POTENTIALS TO WORD CUES THAT SIGNAL POTENTIAL PAIN
    3.1 INTRODUCTION
    3.2 MATERIAL AND METHODS
    3.3 RESULTS
    3.4 DISCUSSION
    3.5 CONCLUSIONS
4 STUDY3 EFFECTS OF TRAIT FEAR OF PAIN ON NEURAL RESPONSES TO CUED POTENTIAL PAIN IN CHRONIC PAIN:AN FMRI STUDY
    4.1 INTRODUCTION
    4.2 METHOD AND MATERIALS
    4.3 RESULTS
    4.4 DISCUSSION
    4.5 CONCLUSION
5 STUDY4 ASSOCIATIONS OF GRAY MATTER VOLUME TO THE PRESENCE OF CHRONIC PAIN:A PRELIMINARY VOXEL-BASED MORPHOMETRY STUDY
    5.1 INTRODUCTION
    5.2 MATERIAL AND METHODS
    5.3 RESULTS
    5.4 DISCUSSION
    5.5 CONCLUSION
6 STUDY5 ALTERATIONS OF AMYGDALA RESTING-STATE FUNCTIONAL CONNECTIVITY IN YOUNG ADULTS WITH CHRONIC PAIN
    6.1 INTRODUCTION
    6.2 MATERIAL AND METHODS
    6.3 RESULTS
    6.4 DISCUSSION
    6.5 CONCLUSIONS
7 STUDY6 TRAIT FEAR OF PAIN AS AN IMPACT ON DECISION MAKING IN CONFLICT SITUATIONS
    7.1 INTRODUCTION
    7.2 MATERIAL AND METHODS
    7.3 RESULTS
    7.4 DISCUSSION
    7.5 CONCLUSIONS
8 STUDY7 THE IMPACT OF DENTAL PAIN FEAR ON TEMPORAL PREFERENCE:DISCOUNTING OF DELAYED PAIN-RELATED AND MONETARY OUTCOMES
    8.1 INTRODUCTION
    8.2 MATERIALS AND METHODS
    8.3 RESULTS
    8.4 DISCUSSION
    8.5 CONCLUSION
9 GENERAL DISCUSSION
10 CONCLUSIONS
REFERENCES
APPENDIX
ACKNOWLEDGEMENTS
ARTICLES PUBLISHED



本文編號：3496531