【摘要】：應激與抑郁癥、心血管疾病及腫瘤等重大疾病的發(fā)生有著密切關(guān)系。前額葉皮層和海馬是調(diào)控應激反應的重要組織,也是應激作用的靶器官。興奮性突觸傳遞是大腦功能活動的重要基礎,應激通過改變遞質(zhì)的釋放和代謝及受體的轉(zhuǎn)運和表達,影響突觸傳遞功能。包括表觀遺傳在內(nèi)的多種細胞內(nèi)信號通路參與了應激的作用機制。揭示這些信號通路可為研發(fā)治療應激相關(guān)疾病的藥物提供潛在的靶點。
[Abstract]:Stress is closely related to the occurrence of major diseases such as depression, cardiovascular disease and tumor. Prefrontal cortex and hippocampus are important tissues to regulate stress response and target organs of stress. Excitatory synaptic transmission is an important basis of brain function. Stress affects synaptic transmission by changing the release and metabolism of transmitters and the transport and expression of receptors. Many intracellular signaling pathways, including epigenetics, are involved in the mechanism of stress. Revealing these signaling pathways could provide potential targets for the development of drugs to treat stress-related diseases.
【作者單位】： 西南大學心理學部認知與人格教育部重點實驗室;
【基金】：西南大學人才基金104530-20700907資助
【分類號】：B845.1
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本文編號：2264118