【摘要】：目的探討海南地區(qū)類(lèi)鼻疽伯克霍爾德菌(BP)對(duì)常用抗生素的敏感性。方法以2008年1月—2013年3月在海南地區(qū)患者中分離的101株非重復(fù)類(lèi)鼻疽伯克霍爾德菌作為研究對(duì)象,采用E-test法對(duì)目前國(guó)際上常用于治療類(lèi)鼻疽的抗生素進(jìn)行藥物敏感試驗(yàn)分析。結(jié)果本實(shí)驗(yàn)收集的101株類(lèi)鼻疽菌中主要是以敗血癥為主,共有60人(59.4%),其次是肺部感染22人(21.8%),傷口及皮膚軟組織感染有17人(16.8%),尿路感染2人(2.0%),受試者總死亡率為17.8%(18/101),其中72.2%(13/18)的死亡患者見(jiàn)于敗血癥患者。體外藥敏試驗(yàn)結(jié)果顯示,本次分離的所有類(lèi)鼻疽對(duì)美羅培南、亞胺培南、左氧氟沙星、頭孢他啶和阿莫西林/克拉維酸均顯示良好的敏感性,敏感率分別為100%、100%、94.4%、92.1%和90.1%。對(duì)四環(huán)素和復(fù)方磺胺甲VA唑的敏感率分別為85.1%和84.2%。結(jié)論本研究和其他地區(qū)的報(bào)道都證實(shí)了類(lèi)鼻疽伯克霍爾德菌對(duì)目前國(guó)際上常用于治療該疾病的抗生素呈現(xiàn)良好的敏感性,其中以亞胺培南和美羅培南的敏感性最好,可作為治療的首選。
[Abstract]:Objective to investigate the sensitivity of Burkholderia gangrenosum (BP) to common antibiotics in Hainan. Methods from January 2008 to March 2013, 101 strains of Berkholderia gangrenoides isolated from patients in Hainan area were selected as the object of study. E-test method was used to analyze the drug sensitivity test of antibiotics commonly used in the treatment of gangrene in the world. Results among the 101 strains of gangrene, 60 cases (59.4%) were septicemia, 22 cases (21.8%) were pulmonary infection, 17 cases (16.8%) were wound, skin and soft tissue infection, 2 cases (2.0%) were urinary tract infection, and the total mortality rate was 17.8% (18 鈮，

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