本文選題：化膿性腦膜炎　切入點(diǎn)：病原菌　出處：《臨床兒科雜志》2017年05期

【摘要】：目的探討兒童化膿性腦膜炎病原菌分布及其對(duì)抗菌藥物的敏感性。方法回顧分析2010年1月-2014年12月收治的54例化膿性腦膜炎患兒的腦脊液涂片及培養(yǎng)結(jié)果。結(jié)果 54株病原菌以革蘭陽(yáng)性球菌為主共36株,革蘭陰性桿菌17株,疑似腦膜炎奈瑟菌1例。革蘭陽(yáng)性球菌中以肺炎鏈球菌為主共31株,革蘭陰性桿菌中以大腸埃希菌為主。革蘭陽(yáng)性球菌中61.3%對(duì)青霉素敏感,90%以上對(duì)頭孢曲松、頭孢吡肟敏感,對(duì)美洛培南敏感率83.3%,對(duì)阿奇霉素耐藥達(dá)94.7%,18株對(duì)苯唑西林耐藥58.1%;在革蘭陰性桿菌中,對(duì)氨芐西林舒巴坦敏感率60%,對(duì)頭孢他啶敏感率71.4%,對(duì)頭孢曲松敏感率57.1%,對(duì)頭孢吡肟敏感率66.6%。結(jié)論濟(jì)南地區(qū)兒童化膿性腦膜炎病原菌以肺炎鏈球菌和大腸埃希菌為主。
[Abstract]:Objective to investigate the distribution of pathogenic bacteria in children with suppurative meningitis and their sensitivity to antimicrobial agents. Methods the cerebrospinal fluid smears of 54 children with suppurative meningitis from January 2010 to December 2014 were retrospectively analyzed. There were 36 strains of Gram-positive cocci in 54 strains. There were 17 Gram-negative bacilli and 1 suspected Neisseria meningitidis. Among the gram-positive cocci, 31 were Streptococcus pneumoniae. Among Gram-negative bacilli, Escherichia coli was the main bacteria. 61.3% of Gram-positive cocci were sensitive to penicillin, more than 90% were sensitive to ceftriaxone and cefepime, and 61.3% were sensitive to ceftriaxone and cefepime. The sensitivity to melopenem was 83.3%, and the resistance to azithromycin was 94.77.18 strains were resistant to oxacillin 58.1%; in Gram-negative bacilli, The sensitivity to ampicillin sulbactam was 60%, to ceftazidime 71.4, to ceftriaxone 57.1, and to cefepime 66.6. Conclusion Streptococcus pneumoniae and Escherichia coli are the main pathogens of suppurative meningitis in Jinan area.
【作者單位】： 濟(jì)南市兒童醫(yī)院;濟(jì)南市婦幼保健院兒科;
【分類號(hào)】：R446.5;R742.9

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