本文關鍵詞： 髓樣細胞觸發(fā)受體 尿源性膿毒血癥 診斷 預后　出處：《中華醫(yī)院感染學雜志》2017年16期 　論文類型：期刊論文

【摘要】：目的探討血清髓樣細胞觸發(fā)受體1(sTREM-1)對尿源性膿毒血癥患者的檢測價值。方法選取2013年1月-2016年1月醫(yī)院泌尿外科收治的114例腔鏡手術后尿源性膿毒血癥患者為研究組,另選同期醫(yī)院行腔鏡手術未發(fā)生尿源性膿毒血癥患者100例為對照組;入院24h后、術后1h、術后1、3、7d檢測sTREM-1、降鈣素原(PCT)、C-反應蛋白(CRP)、白介素6(IL-6)水平;同時根據(jù)患者入院24h內(nèi)各項指標的最差值進行急性生理及慢性健康評分標準Ⅱ(APACHEⅡ)評分,記錄兩組患者30d內(nèi)存活情況。結果入院24h后、術后1h、術后1、3、7d研究組sTREM-1均顯著高于對照組(P0.05);與PCT、CRP和IL-6相比,sTREM-1診斷尿膿毒血癥的敏感性、特異性、陽性預測值和陰性預測值均較高;Spearman相關性分析結果顯示,sTREM-1(r=0.859,P0.01)、PCT(r=0.732,P0.01)、CRP(r=0.502,P=0.025)和IL-6(r=0.431,P=0.032)與APACHEⅡ均存在明顯正相關性;114例尿源性膿毒血癥患者30d內(nèi)死亡31例,病死率為27.19%;死亡組sTREM-1、PCT、CRP和IL-6峰值濃度均顯著高于存活組(P0.05);sTREM-1濃度與尿源性膿毒血癥死亡患者生存時間的相關性分析結果顯示,sTREM-1峰值濃度(r=-0.651,P0.01)與預后呈負相關。結論 sTREM-1在尿源性膿毒血癥早期診斷、病情評估和預后判斷中具有指導意義。
[Abstract]:Objective to investigate the value of serum myeloid cell trigger receptor (TREM-1) in the detection of urogenic sepsis. Methods 114 patients with urogenic sepsis treated in urology from January 2013 to January 2016 were selected as study group. In the same period, 100 patients with urogenic sepsis were selected as the control group, the levels of sTREM-1, PCTC-reactive protein and interleukin-6 (IL-6) were detected at 24 hours after admission, 1 hour after operation and 1 day 3 days after operation. At the same time, according to the worst value of each index within 24 hours after admission, the acute physiological and chronic health scoring criteria 鈪，

本文編號：1497859