【摘要】：目的:觀察壯醫(yī)藥線點灸結合西醫(yī)常規(guī)療法治療尋常型銀屑病的臨床療效及安全性,為臨床上使用該療法治療尋常型銀屑病提供依據。方法:首先采用隨機數字表法,將50例尋常型銀屑病患者隨機分為試驗組25例,對照組25例。對照組采用西醫(yī)常規(guī)療法治療,療程30天。試驗組在對照組的治療基礎上加用壯醫(yī)藥線點灸療法治療,壯醫(yī)藥線點灸療法隔天治療1次,共治療15次。療程結束后,對皮損面積和嚴重程度(PASI)進行療效評價,對瘙癢等級、皮膚病生活質量指數量表(DLQI)、漢密頓焦慮量表(HAMA)(包括焦慮心境、緊張、失眠等)進行評價分析。采用實驗室安全性評價指標及不良事件發(fā)生情況對結局進行安全性評價。結果:經30天治療后,兩組各有25例完成試驗。試驗組達到臨床治愈的0例、顯效13例、有效9例、無效3例,有效率88%;對照組達到臨床治愈的0例、顯效4例、有效10例、無效11例,有效率56%。兩組有效率比較,差異有統計學意義(P0.05)。在改善患者皮損面積和嚴重程度、減輕瘙癢、緩解焦慮、提高患者生活質量方面,試驗組優(yōu)于對照組,兩組差異有顯著統計學意義(P0.01);兩組均未出現安全性指標異常。對照組1例患者出現輕微惡心、腹瀉;試驗組1例患者點灸一段時間后點灸局部出現淺表的灼傷痕跡伴瘙癢,癥狀輕微。結論:壯醫(yī)藥線點灸結合西醫(yī)常規(guī)療法治療尋常型銀屑病在改善患者皮損面積和嚴重程度、減輕瘙癢、緩解焦慮、提高患者生活質量等方面的臨床療效,優(yōu)于單獨使用西醫(yī)常規(guī)療法,且無明顯不良反應及毒副作用,安全性高。
[Abstract]:Objective: to observe the clinical efficacy and safety of Zhuang medicine line moxibustion combined with routine western medicine therapy in the treatment of psoriasis vulgaris, and to provide evidence for clinical use of this therapy in the treatment of psoriasis vulgaris. Methods: 50 patients with psoriasis vulgaris were randomly divided into experimental group (n = 25) and control group (n = 25). The control group was treated with routine western medicine for 30 days. On the basis of the treatment of the control group, the experimental group was treated with Zhuang medicine line moxibustion therapy, and Zhuang medicine line moxibustion therapy was treated once every other day for a total of 15 times. At the end of the course of treatment, the curative effect of (PASI) on skin lesion area and severity was evaluated. For pruritus grade, skin disease quality of life index scale (DLQI), Hamilton anxiety scale (HAMA) (, including anxiety mood, tension. Insomnia, etc.) for evaluation and analysis. The safety evaluation index of laboratory and the occurrence of adverse events were used to evaluate the safety of the outcome. Results: after 30 days of treatment, 25 cases in each group completed the trial. In the experimental group, 0 cases were clinically cured, 13 cases were markedly effective, 9 cases were effective, 3 cases were ineffective, the effective rate was 88%, while in the control group, 0 cases were clinically cured, 4 cases were markedly effective, 10 cases were effective, 11 cases were ineffective, the effective rate was 56%. There was significant difference in the effective rate between the two groups (P 0.05). The experimental group was superior to the control group in improving the area and severity of skin lesions, reducing pruritus, relieving anxiety and improving the quality of life of the patients, and there was significant difference between the two groups (P 0.01). There was no abnormal safety index between the two groups. One patient in the control group had slight nausea and diarrhea, and one patient in the experimental group had superficial burn marks with pruritus after moxibustion for a period of time, and the symptoms were mild. Conclusion: Zhuang medicine line moxibustion combined with routine western medicine therapy in the treatment of psoriasis vulgaris is effective in improving the area and severity of skin lesions, reducing pruritus, relieving anxiety and improving the quality of life of patients. It is superior to routine western medicine alone, and has no obvious adverse reactions and side effects, and has high safety.
【學位授予單位】：廣西中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R29

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