【摘要】：目的:觀察益氣祛瘀飲對慢性心力衰竭氣虛血瘀證治療的臨床療效,并從中、西醫(yī)兩方面初步探究、討論其作用機理。方法:將符合診斷與納入標準的60例病例隨機分為治療組和對照組各30例,對照組給予西醫(yī)標準治療,治療組在西醫(yī)標準治療基礎上加用中藥益氣祛瘀飲,均治療28天,記錄患者治療前后心功能NYHA分級、氨基末端腦納素前體(NT-proBNP)、左室射血分數(shù)(LVEF)、6分鐘步行距離和中醫(yī)證候積分療效,并采用SPSS17.0進行統(tǒng)計學分析。成果:治療組心功能改善總有效率為100%,與對照組總有效率80%相比,有顯著差異(P0.05)。兩組血清NT-proBNP均有非常顯著下降(P0.01),但治療組治療后NT-proBNP的值明顯低于對照組(P0.01),兩組LVEF和6分鐘步行試驗距離均有非常顯著上升(P0.01),且治療組改善幅度明顯高于對照組(P0.05)。對中醫(yī)評價指標的比較中,中醫(yī)證候總積分治療組療效明顯優(yōu)于對照組(P0.05),單個癥狀評分療效治療組也優(yōu)于對照組,且除口干P0.05外,其余差異均有統(tǒng)計學意義。結(jié)論:益氣祛瘀飲聯(lián)合西藥標準治療慢性心力衰竭氣虛血瘀證,對于改善患者心功能,和改善無論總體還是單個中醫(yī)癥狀改善均較單用西藥治療有顯著作用。
[Abstract]:Objective: to observe the clinical effect of Yiqi Quyu decoction on qi deficiency and blood stasis syndrome of chronic heart failure and discuss its mechanism. Methods: sixty patients who met the criteria of diagnosis and inclusion were randomly divided into treatment group (n = 30) and control group (n = 30). The control group was treated with western medicine standard therapy. The treatment group was treated with traditional Chinese medicine Yiqi Quyu decoction on the basis of western medicine standard treatment for 28 days. The NYHA classification of cardiac function, amino-terminal nana precursor (NT-proBNP), 6-minute walking distance of left ventricular ejection fraction (LVEF),) and the curative effect of TCM syndromes were recorded before and after treatment. The results were statistically analyzed by SPSS17.0. Results: the total effective rate of heart function improvement in the treatment group was 100%, which was significantly different from that in the control group (80%) (P0.05). Serum NT-proBNP decreased significantly in both groups (P0.01), but the value of NT-proBNP in the treatment group was significantly lower than that in the control group (P0.01). The distance of LVEF and 6-minute walking test was significantly increased in both groups (P0.01). The improvement of the treatment group was significantly higher than that of the control group (P0.05). In the comparison of TCM evaluation indexes, the curative effect of the treatment group was significantly better than that of the control group (P0.05), the treatment group of single symptom score was also superior to the control group, and the other differences were statistically significant except for the dry mouth P0.05. Conclusion: the combination of Yiqi Quyu Yin and western medicine standard in the treatment of chronic heart failure syndrome of qi deficiency and blood stasis has a significant effect on improving the heart function of patients and improving the symptoms of both general and individual Chinese medicine.
【學位授予單位】：山東中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R259

【參考文獻】

相關期刊論文 前10條

1 張建平;張淼;王煥玲;張紅霞;;田芬蘭對心脾相關的認識[J];河南中醫(yī);2015年01期

2 張曉華;劉淑榮;尹雪;;心力衰竭中醫(yī)病機及證候演變研究進展[J];中國中醫(yī)急癥;2013年10期

3 吳偉;劉勇;趙英強;;心衰作為心力衰竭的中醫(yī)病名探究[J];中醫(yī)雜志;2013年10期

4 邱雅慧;薛凌;高夏青;;丹參多酚酸鹽對慢性心力衰竭患者心功能及炎癥因子的影響[J];中國實驗方劑學雜志;2013年07期

5 農(nóng)祥兵;;慢性心力衰竭的治療進展[J];實用心腦肺血管病雜志;2013年03期

6 袁國強;李彥霞;魏聰;;從脈絡學說論治慢性心力衰竭[J];中國中醫(yī)基礎醫(yī)學雜志;2012年08期

7 李慶洋;;慢性心力衰竭的藥物治療進展及其現(xiàn)狀[J];實用心腦肺血管病雜志;2012年06期

8 張云;王階;吳廣均;劉瑞華;;丹參酚酸B抑制TLR4-NFκB-TNFα炎癥損傷通路防治心肌細胞的缺氧損傷[J];遼寧中醫(yī)雜志;2012年01期

9 安芳;王林;黃姣紅;楊艷華;李廣平;馬金萍;;利尿劑對慢性心力衰竭住院患者預后影響的回顧性分析[J];天津醫(yī)藥;2009年01期

10 劉柏年;殷雅琴;;醛固酮受體拮抗劑治療慢性心力衰竭[J];醫(yī)學綜述;2008年13期

，

本文編號：2421823