紅花注射液關(guān)節(jié)腔沖洗結(jié)合鉤針治療膝骨性關(guān)節(jié)炎的臨床療效觀察
發(fā)布時(shí)間：2019-01-03 06:23
【摘要】：目的通過采用紅花注射液關(guān)節(jié)腔沖洗結(jié)合鉤針治療膝關(guān)節(jié)骨性關(guān)節(jié)炎,依據(jù)Lysholm膝關(guān)節(jié)評分、膝關(guān)節(jié)HSS評分法評價(jià)其臨床療效,總結(jié)分析紅花注射液關(guān)節(jié)腔沖洗結(jié)合鉤針治療膝關(guān)節(jié)骨性關(guān)節(jié)炎的臨床療效。方法采用臨床隨機(jī)對照法進(jìn)行研究,選擇2014年11月至2015年5月就診于山西省中西醫(yī)結(jié)合醫(yī)院疼痛科且符合納入標(biāo)準(zhǔn)的膝關(guān)節(jié)骨性關(guān)節(jié)炎住院患者,臨床收集90例,年齡50—80歲,并依據(jù)患者就診順序按Doll’s隨機(jī)數(shù)字表法分為生理鹽水沖洗組(A組)、紅花注射液關(guān)節(jié)腔沖洗組(B組)、紅花注射液關(guān)節(jié)腔沖洗結(jié)合鉤針治療組(C組),A組為對照組,B組和C組為試驗(yàn)組,每組各30例。治療前依據(jù)Lysholm膝關(guān)節(jié)評分、膝關(guān)節(jié)HSS評分法進(jìn)行治療前評分,完善相關(guān)輔助檢查后對符合納入標(biāo)準(zhǔn)的患者分別采用上述三種方法進(jìn)行治療,各治療兩次�；颊咧委熃Y(jié)束后一周及出院1月后隨訪,依據(jù)Lysholm膝關(guān)節(jié)評分、膝關(guān)節(jié)HSS評分法進(jìn)行評分。臨床研究的數(shù)據(jù)資料采用SPSS 17.0統(tǒng)計(jì)軟件分析,對所獲數(shù)據(jù)采用完全隨機(jī)的多組樣本均數(shù)比較,使用單因素方差分析法(ANOVA),數(shù)據(jù)以x±S表示,以P0.05為有差異性,具有統(tǒng)計(jì)學(xué)意義。若數(shù)據(jù)呈正態(tài)分布,方差齊,且各組數(shù)值之間有統(tǒng)計(jì)學(xué)意義,用LSD檢驗(yàn)進(jìn)行多重比較分析;若方差不齊,在有統(tǒng)計(jì)學(xué)意義的基礎(chǔ)上,采用Tamhane’s T2檢驗(yàn)進(jìn)行多重比較。結(jié)果(1)三組在患者年齡、性別、病程、單雙膝關(guān)節(jié)數(shù)量方面比較,經(jīng)方差分析檢驗(yàn),P0.05,差異無統(tǒng)計(jì)學(xué)意義;(2)三組患者治療前Lysholm膝關(guān)節(jié)評分、膝關(guān)節(jié)HSS評分比較,經(jīng)方差分析檢驗(yàn),P0.05,差異無統(tǒng)計(jì)學(xué)意義;(3)三組患者治療前病情嚴(yán)重程度比較,經(jīng)方差分析檢驗(yàn),P0.05,差異無統(tǒng)計(jì)學(xué)意義;(4)治療后1周及治療后1月與治療前對比,依據(jù)Lysholm膝關(guān)節(jié)評分、膝關(guān)節(jié)HSS評分法比較,經(jīng)方差分析檢驗(yàn),三組P值均0.05,差異有統(tǒng)計(jì)學(xué)意義;(5)治療后1周三組之間進(jìn)行療效對比,A組與B組相比,經(jīng)方差分析檢驗(yàn),P0.05,差異無統(tǒng)計(jì)學(xué)意義,A組與C組相比,P0.05,差異有統(tǒng)計(jì)學(xué)意義,B組與C組相比,P0.05,差異有統(tǒng)計(jì)學(xué)意義;(6)治療后1月三組之間進(jìn)行療效對比,經(jīng)方差分析檢驗(yàn),依據(jù)Lysholm膝關(guān)節(jié)評分,A組與B組相比,P0.05,差異無統(tǒng)計(jì)學(xué)意義,A組與C組相比,P0.05,差異有統(tǒng)計(jì)學(xué)意義,B組與C組相比,P0.05,差異有統(tǒng)計(jì)學(xué)意義;而依據(jù)膝關(guān)節(jié)HSS評分,三組之間對比,P值均0.05,差異有統(tǒng)計(jì)學(xué)意義;(7)治療后1周及治療后1月三組之間總體療效對比,經(jīng)方差分析檢驗(yàn),P0.05,差異具有統(tǒng)計(jì)學(xué)意義,可以認(rèn)為三組療效有差異,而C組總體療效均優(yōu)于A組和B組。結(jié)論紅花注射液關(guān)節(jié)腔沖洗結(jié)合鉤針治療膝骨性關(guān)節(jié)炎較單純采用關(guān)節(jié)腔沖洗相比,取得較好臨床療效,是治療KOA安全有效、療效確切的方法。
[Abstract]:Objective to evaluate the clinical efficacy of safflower injection combined with crochet needle in the treatment of knee osteoarthritis according to Lysholm knee score and knee joint HSS score. To summarize and analyze the clinical effect of safflower injection combined with crochet needle in the treatment of knee osteoarthritis. Methods from November 2014 to May 2015, 90 patients with knee osteoarthritis, who were admitted to the pain Department of Shanxi Integrated Chinese and Western Medicine Hospital and met the inclusion criteria, were selected from a randomized controlled clinical study. The patients aged 50-80 years were randomly divided into two groups: saline irrigation group (group A) and safflower injection joint cavity irrigation group (group B) according to the Doll's sequence. Safflower injection combined with crochet needle treatment group (group C), A as control group, B group and C group as experimental group, 30 cases in each group). According to the Lysholm knee joint score and the knee joint HSS score before treatment, the patients who met the inclusion criteria were treated with the above three methods respectively, two times each after the improvement of relevant auxiliary examination. The patients were followed up one week after treatment and one month after discharge. According to Lysholm knee score and knee joint HSS score. The data of clinical study were analyzed by SPSS 17.0 statistical software. The data were compared with each other by random multi-group sample mean. The (ANOVA), data of single factor variance analysis was expressed as x 鹵S, and the difference was P0.05. It has statistical significance. If the data is normal distribution, the variance is homogeneous, and there is statistical significance among the values of each group, the LSD test is used to carry out multiple comparative analysis; if the variance is not uniform, on the basis of statistical significance, the Tamhane's T2 test is used to carry out multiple comparisons. Results (1) there was no significant difference among the three groups in age, sex, course of disease and the number of single and double knee joints. The variance analysis showed that there was no significant difference between the three groups in age, sex, course of disease and the number of single and double knee joints. (2) there was no significant difference in Lysholm knee joint score and knee joint HSS score between the three groups before treatment (P 0.05). (3) there was no significant difference in the severity of the disease between the three groups before treatment (P 0.05). (4) 1 week after treatment and 1 month after treatment compared with before treatment, according to Lysholm knee joint score, knee joint HSS score comparison, by variance analysis test, the three groups P value were 0.05, the difference was statistically significant; (5) there was no significant difference between group A and group B by ANOVA test (P0.05), the difference between group A and group C (P0.05) was statistically significant, the difference between group A and group C was statistically significant, and the difference between group B and group C was statistically significant. P0.05, the difference was statistically significant. (6) after 1 month of treatment, the curative effect was compared among the three groups. According to the Lysholm knee joint score, there was no significant difference between group A and group B (P0.05, P 0.05, P 0.05). The difference was statistically significant, compared with group C, P 0.05, the difference was statistically significant. According to the HSS score of knee joint, there were significant differences among the three groups (P = 0.05). (7) the total curative effect of group C was better than that of group A and B after 1 week of treatment and 1 month after treatment. The variance analysis showed that the difference was statistically significant (P0.05), and the total curative effect of group C was better than that of group A and B. Conclusion the safflower injection combined with crochet needle in the treatment of knee osteoarthritis has a better clinical effect than that of simple joint cavity washing. It is a safe and effective method for the treatment of KOA.
【學(xué)位授予單位】：山西中醫(yī)學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R274.9
本文編號(hào)：2399004
[Abstract]:Objective to evaluate the clinical efficacy of safflower injection combined with crochet needle in the treatment of knee osteoarthritis according to Lysholm knee score and knee joint HSS score. To summarize and analyze the clinical effect of safflower injection combined with crochet needle in the treatment of knee osteoarthritis. Methods from November 2014 to May 2015, 90 patients with knee osteoarthritis, who were admitted to the pain Department of Shanxi Integrated Chinese and Western Medicine Hospital and met the inclusion criteria, were selected from a randomized controlled clinical study. The patients aged 50-80 years were randomly divided into two groups: saline irrigation group (group A) and safflower injection joint cavity irrigation group (group B) according to the Doll's sequence. Safflower injection combined with crochet needle treatment group (group C), A as control group, B group and C group as experimental group, 30 cases in each group). According to the Lysholm knee joint score and the knee joint HSS score before treatment, the patients who met the inclusion criteria were treated with the above three methods respectively, two times each after the improvement of relevant auxiliary examination. The patients were followed up one week after treatment and one month after discharge. According to Lysholm knee score and knee joint HSS score. The data of clinical study were analyzed by SPSS 17.0 statistical software. The data were compared with each other by random multi-group sample mean. The (ANOVA), data of single factor variance analysis was expressed as x 鹵S, and the difference was P0.05. It has statistical significance. If the data is normal distribution, the variance is homogeneous, and there is statistical significance among the values of each group, the LSD test is used to carry out multiple comparative analysis; if the variance is not uniform, on the basis of statistical significance, the Tamhane's T2 test is used to carry out multiple comparisons. Results (1) there was no significant difference among the three groups in age, sex, course of disease and the number of single and double knee joints. The variance analysis showed that there was no significant difference between the three groups in age, sex, course of disease and the number of single and double knee joints. (2) there was no significant difference in Lysholm knee joint score and knee joint HSS score between the three groups before treatment (P 0.05). (3) there was no significant difference in the severity of the disease between the three groups before treatment (P 0.05). (4) 1 week after treatment and 1 month after treatment compared with before treatment, according to Lysholm knee joint score, knee joint HSS score comparison, by variance analysis test, the three groups P value were 0.05, the difference was statistically significant; (5) there was no significant difference between group A and group B by ANOVA test (P0.05), the difference between group A and group C (P0.05) was statistically significant, the difference between group A and group C was statistically significant, and the difference between group B and group C was statistically significant. P0.05, the difference was statistically significant. (6) after 1 month of treatment, the curative effect was compared among the three groups. According to the Lysholm knee joint score, there was no significant difference between group A and group B (P0.05, P 0.05, P 0.05). The difference was statistically significant, compared with group C, P 0.05, the difference was statistically significant. According to the HSS score of knee joint, there were significant differences among the three groups (P = 0.05). (7) the total curative effect of group C was better than that of group A and B after 1 week of treatment and 1 month after treatment. The variance analysis showed that the difference was statistically significant (P0.05), and the total curative effect of group C was better than that of group A and B. Conclusion the safflower injection combined with crochet needle in the treatment of knee osteoarthritis has a better clinical effect than that of simple joint cavity washing. It is a safe and effective method for the treatment of KOA.
【學(xué)位授予單位】：山西中醫(yī)學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R274.9
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