【摘要】：目的:通過(guò)觀察痛風(fēng)方治療濕熱夾瘀型痛風(fēng)患者的臨床療效,評(píng)價(jià)其有效性及安全性。方法:采用隨機(jī)平行對(duì)照方法,將120例患者分為對(duì)照組和觀察組,各60例,對(duì)照組給予口服塞來(lái)昔布膠囊0.2 g/次,2次/d。觀察組在對(duì)照組基礎(chǔ)上加服痛風(fēng)方,1劑/d,兩組患者療程均為2周。分別記錄治療前和治療后患者休息時(shí)關(guān)節(jié)腫痛分?jǐn)?shù),關(guān)節(jié)壓痛分?jǐn)?shù),關(guān)節(jié)腫脹分?jǐn)?shù),總分?jǐn)?shù),關(guān)節(jié)腫痛指數(shù),關(guān)節(jié)功能分級(jí),C反應(yīng)蛋白(CRP),血沉(ESR),D-二聚體(DD-i),血尿酸(UA)水平及生活質(zhì)量評(píng)分(SF-36)的改變,并記錄不良反應(yīng)發(fā)生情況。結(jié)果:經(jīng)治療2周后,觀察組臨床有效率為87.27%,高于對(duì)照組的66.04%(χ2=7.536,P0.05);觀察組休息時(shí)關(guān)節(jié)腫痛分?jǐn)?shù),關(guān)節(jié)壓痛分?jǐn)?shù),總分?jǐn)?shù),關(guān)節(jié)功能評(píng)分,CRP,ESR,DD-i,UA均低于對(duì)照組(P0.05);觀察組關(guān)節(jié)腫痛指數(shù),生活質(zhì)量SF-36評(píng)分均高于對(duì)照組(P0.05)。兩組患者不良事件發(fā)生率無(wú)統(tǒng)計(jì)學(xué)差異。結(jié)論:痛風(fēng)方聯(lián)合塞來(lái)昔布治療濕熱夾瘀型痛風(fēng)性關(guān)節(jié)炎療效確切,抗炎作用強(qiáng),安全性好,且能降低血尿酸水平而不誘發(fā)痛風(fēng)急性發(fā)作。
[Abstract]:Objective: to evaluate the efficacy and safety of gout prescription in treating gout patients with dampness and heat entrapment. Methods: 120 patients were randomly divided into two groups: control group (n = 60) and observation group (n = 60). The control group was treated with celecoxib capsule 0.2 g / d, twice a day. Observation group on the basis of the control group plus gout prescription, 1 dose per day, two groups of patients were treated for 2 weeks. The swelling and pain score, tenderness score, swelling score, total score, swelling index, function grade, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR),) were recorded before and after treatment. Changes of D-dimer (DD-i), serum uric acid (UA) level and quality of life score (SF-36) were recorded. Results: after 2 weeks of treatment, the clinical effective rate of the observation group was 87.27%, which was higher than that of the control group (66.04%) (蠂 2 / 7.536P 0.05). The scores of joint swelling and pain, joint tenderness, total score, joint function score and CRP,ESR,DD-i,UA in the observation group were lower than those in the control group (P0.05). The index of joint swelling and pain and the SF-36 score of quality of life in the observation group were higher than those in the control group (P0.05). There was no significant difference in the incidence of adverse events between the two groups. Conclusion: gout prescription combined with celecoxib is effective in treating gouty arthritis of damp-heat and stasis type, has strong anti-inflammatory effect, good safety, and can reduce the level of uric acid without inducing acute attack of gout.
【作者單位】： 廣州中醫(yī)藥大學(xué)第一臨床醫(yī)學(xué)院;廣州中醫(yī)藥大學(xué)第一附屬醫(yī)院;
【基金】：國(guó)家自然科學(xué)基金項(xiàng)目(81573930)
【分類號(hào)】：R259

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 李季;肖瑞崇;李東書(shū);;中醫(yī)藥治療痛風(fēng)的Meta分析[J];中國(guó)中醫(yī)急癥;2016年11期

2 曾小峰;陳耀龍;;2016中國(guó)痛風(fēng)診療指南[J];中華內(nèi)科雜志;2016年11期

3 黃潯芳;;桂枝茯苓丸治療子宮內(nèi)膜異位癥的療效觀察[J];當(dāng)代醫(yī)學(xué);2013年31期

4 王兵;侯煒;;《金匱要略》三丸方治療腫瘤探討[J];中醫(yī)學(xué)報(bào);2013年10期

5 曾金祥;魏娟;畢瑩;王曉云;朱繼孝;朱玉野;周強(qiáng);羅光明;熊浩仲;;車前子醇提物降低急性高尿酸血癥小鼠血尿酸水平及機(jī)制研究[J];中國(guó)實(shí)驗(yàn)方劑學(xué)雜志;2013年09期

6 馮娜;劉芳;郭會(huì)彩;曹阿芳;王素敏;;車前子多糖抗炎作用機(jī)制的實(shí)驗(yàn)研究[J];天津醫(yī)藥;2012年06期

7 李莎;林昌松;;林昌松運(yùn)用桂枝茯苓丸治療風(fēng)濕病經(jīng)驗(yàn)擷要[J];江西中醫(yī)藥;2012年04期

8 朱婉華;顧冬梅;蔣恬;朱良春;;濁瘀痹——痛風(fēng)中醫(yī)病名探討[J];中醫(yī)雜志;2011年17期

9 吳修紅;劉麗佳;王喜軍;;桂枝茯苓丸及組成中藥化學(xué)成分研究進(jìn)展[J];中醫(yī)藥學(xué)報(bào);2010年06期

10 姬森國(guó);徐強(qiáng);王笑丹;林昌松;;林昌松教授治療痛風(fēng)性關(guān)節(jié)炎經(jīng)驗(yàn)[J];遼寧中醫(yī)藥大學(xué)學(xué)報(bào);2010年08期

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 胡妮娜;趙闖;張金琦;王旭;楊東霞;吳修紅;;桂枝茯苓丸治療子宮內(nèi)膜異位癥的臨床及機(jī)制研究進(jìn)展[J];中醫(yī)藥學(xué)報(bào);2017年04期

2 劉曉帥;王果;汪林;沈曉飛;鐘振東;李軍暉;楊帆;;桂枝茯苓丸抗大鼠慢性心衰的實(shí)驗(yàn)研究[J];西南民族大學(xué)學(xué)報(bào)(自然科學(xué)版);2017年04期

3 張衛(wèi)忠;王友蓮;;江西某痛風(fēng)村患者診治及HLA-B5801基因攜帶情況分析[J];江西醫(yī)藥;2017年07期

4 樸勇洙;韓隆胤;任曉杰;;三石湯加減治療痛風(fēng)急性發(fā)作驗(yàn)案[J];中醫(yī)藥信息;2017年04期

5 陳sビ，

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