【摘要】：目的:通過觀察痛風(fēng)方治療濕熱夾瘀型痛風(fēng)患者的臨床療效,評價(jià)其有效性及安全性。方法:采用隨機(jī)平行對照方法,將120例患者分為對照組和觀察組,各60例,對照組給予口服塞來昔布膠囊0.2 g/次,2次/d。觀察組在對照組基礎(chǔ)上加服痛風(fēng)方,1劑/d,兩組患者療程均為2周。分別記錄治療前和治療后患者休息時(shí)關(guān)節(jié)腫痛分?jǐn)?shù),關(guān)節(jié)壓痛分?jǐn)?shù),關(guān)節(jié)腫脹分?jǐn)?shù),總分?jǐn)?shù),關(guān)節(jié)腫痛指數(shù),關(guān)節(jié)功能分級,C反應(yīng)蛋白(CRP),血沉(ESR),D-二聚體(DD-i),血尿酸(UA)水平及生活質(zhì)量評分(SF-36)的改變,并記錄不良反應(yīng)發(fā)生情況。結(jié)果:經(jīng)治療2周后,觀察組臨床有效率為87.27%,高于對照組的66.04%(χ2=7.536,P0.05);觀察組休息時(shí)關(guān)節(jié)腫痛分?jǐn)?shù),關(guān)節(jié)壓痛分?jǐn)?shù),總分?jǐn)?shù),關(guān)節(jié)功能評分,CRP,ESR,DD-i,UA均低于對照組(P0.05);觀察組關(guān)節(jié)腫痛指數(shù),生活質(zhì)量SF-36評分均高于對照組(P0.05)。兩組患者不良事件發(fā)生率無統(tǒng)計(jì)學(xué)差異。結(jié)論:痛風(fēng)方聯(lián)合塞來昔布治療濕熱夾瘀型痛風(fēng)性關(guān)節(jié)炎療效確切,抗炎作用強(qiáng),安全性好,且能降低血尿酸水平而不誘發(fā)痛風(fēng)急性發(fā)作。
[Abstract]:Objective: to evaluate the efficacy and safety of gout prescription in treating gout patients with dampness and heat entrapment. Methods: 120 patients were randomly divided into two groups: control group (n = 60) and observation group (n = 60). The control group was treated with celecoxib capsule 0.2 g / d, twice a day. Observation group on the basis of the control group plus gout prescription, 1 dose per day, two groups of patients were treated for 2 weeks. The swelling and pain score, tenderness score, swelling score, total score, swelling index, function grade, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR),) were recorded before and after treatment. Changes of D-dimer (DD-i), serum uric acid (UA) level and quality of life score (SF-36) were recorded. Results: after 2 weeks of treatment, the clinical effective rate of the observation group was 87.27%, which was higher than that of the control group (66.04%) (蠂 2 / 7.536P 0.05). The scores of joint swelling and pain, joint tenderness, total score, joint function score and CRP,ESR,DD-i,UA in the observation group were lower than those in the control group (P0.05). The index of joint swelling and pain and the SF-36 score of quality of life in the observation group were higher than those in the control group (P0.05). There was no significant difference in the incidence of adverse events between the two groups. Conclusion: gout prescription combined with celecoxib is effective in treating gouty arthritis of damp-heat and stasis type, has strong anti-inflammatory effect, good safety, and can reduce the level of uric acid without inducing acute attack of gout.
【作者單位】： 廣州中醫(yī)藥大學(xué)第一臨床醫(yī)學(xué)院;廣州中醫(yī)藥大學(xué)第一附屬醫(yī)院;
【基金】：國家自然科學(xué)基金項(xiàng)目(81573930)
【分類號】：R259

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