發(fā)布時(shí)間：2018-09-06 12:14

【摘要】：目的研究電針對(duì)椎間盤(pán)脫出模型犬脊髓損傷的修復(fù)作用及其對(duì)體感誘發(fā)電位(somatosensory evoked potential,SEP)的影響。方法比格犬隨機(jī)分為三組,模型組和電針組采用球囊壓迫法制作椎間盤(pán)脫出模型,電針組術(shù)后每天電針治療;對(duì)照組進(jìn)行假手術(shù)處理。術(shù)前(0 d)和術(shù)后1、4、7、14 d每只犬均使用德克薩斯犬脊髓損傷Texas Spinal Cord Injury Scale for Dogs(TSCIS)評(píng)分法評(píng)分,使用肌電誘發(fā)電位儀測(cè)量SEP并分析其潛伏期和波幅。結(jié)果術(shù)后1 d模型組和電針組與對(duì)照組TSCIS評(píng)分相比均顯著降低(P0.01),術(shù)后14 d,電針組與模型組相比差異有顯著性(P0.01);術(shù)后4 d模型組和電針組的SEP潛伏期相比顯著降低(P0.05),術(shù)后14 d,電針組與模型組的潛伏期相比差異有顯著性(P0.05);術(shù)后1 d模型組和電針組的SEP波幅與對(duì)照組相比顯著降低(P0.05),術(shù)后14 d,電針組與模型組的波幅相比差異有顯著性(P0.05)。結(jié)論電針能夠有效促進(jìn)椎間盤(pán)脫出模型犬的脊髓損傷修復(fù),提高TSCIS評(píng)分,恢復(fù)SEP波形,縮短其潛伏期,提升其波幅;SEP能夠在一定程度上反應(yīng)脊髓損傷程度,評(píng)價(jià)電針治療效果。
[Abstract]:Objective to study the effect of electroacupuncture on repairing spinal cord injury and somatosensory evoked potential (somatosensory evoked potential,SEP) in dogs with prolapse of intervertebral disc. Methods Beagle dogs were randomly divided into three groups. The model group and the electroacupuncture group were used to make the model of prolapse of intervertebral disc by balloon compression. The electroacupuncture group was treated with electroacupuncture every day after operation, and the control group was treated with sham operation. The Texas Spinal Cord Injury Scale for Dogs (TSCIS) score of spinal cord injury in Texas canine was evaluated by Texas Spinal Cord Injury Scale for Dogs (TSCIS) score before operation (0 d) and 1 day 4 and 7 days after operation. SEP was measured by EMG potentiometer and its latency and amplitude were analyzed. Results the TSCIS scores in the model group and electroacupuncture group were significantly lower than those in the control group on the 1st day after operation (P0.01), and on the 14th day after operation, there was a significant difference between the electroacupuncture group and the model group (P0.01), and the latency of SEP in the model group and electroacupuncture group on the 4th day after operation was significantly lower than that in the control group (P0.01). (P0.05), 14 days after operation, the latency of electroacupuncture group and model group was significantly different (P0.05), the amplitude of SEP in model group and electroacupuncture group was significantly lower than that in control group on the 1st day after operation (P0.05), the amplitude of SEP in electroacupuncture group and model group was significantly higher than that in model group at 14 days after operation (P0.05). Conclusion electroacupuncture can effectively promote the repair of spinal cord injury in model dogs with intervertebral disc prolapse, improve the score of TSCIS, restore the waveform of SEP, shorten the latent period, increase the amplitude of SEP and reflect the degree of spinal cord injury to a certain extent, and evaluate the effect of electroacupuncture on the treatment of spinal cord injury.
【作者單位】： 北京農(nóng)學(xué)院動(dòng)物科學(xué)技術(shù)學(xué)院;北京農(nóng)學(xué)院獸醫(yī)學(xué)(中醫(yī)藥)北京市重點(diǎn)實(shí)驗(yàn)室;
【基金】：國(guó)家自然科學(xué)基金項(xiàng)目(No.31372473) 北京農(nóng)學(xué)院學(xué)位與研究生教育改革與發(fā)展項(xiàng)目(No.5056516004/024)
【分類號(hào)】：R245

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