本文選題：病態(tài)竇房結(jié)綜合征 + 溫陽(yáng)益氣��； 參考：《山東中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:運(yùn)用循證醫(yī)學(xué)系統(tǒng)評(píng)價(jià)的方法對(duì)溫陽(yáng)益氣法治療病態(tài)竇房結(jié)綜合征的臨床研究文獻(xiàn)進(jìn)行分析�；跀�(shù)據(jù)挖掘,探索病竇綜合征的用藥特點(diǎn)、配伍規(guī)律,為中藥治療病竇提供科學(xué)依據(jù)和新的思路。方法:1.通過(guò)電子檢索和手工檢索,檢索溫陽(yáng)益氣法治療病態(tài)竇房結(jié)綜合征的臨床隨機(jī)對(duì)照試驗(yàn)研究,采用Jadad評(píng)分標(biāo)準(zhǔn)評(píng)價(jià)納入研究文獻(xiàn)質(zhì)量,利用RevMan5.2軟件對(duì)多個(gè)研究結(jié)果的總體效應(yīng)進(jìn)行Meta-分析、倒漏斗圖分析。2.基于數(shù)據(jù)挖據(jù),運(yùn)用SPSS 17.0軟件進(jìn)行數(shù)據(jù)的一般處理、頻數(shù)分析等,選擇PSS Clementine 12.0軟件進(jìn)行關(guān)聯(lián)規(guī)則分析,探索用藥規(guī)律。結(jié)果:1.系統(tǒng)評(píng)價(jià)共納入16篇隨機(jī)對(duì)照臨床試驗(yàn),共1181例患者,Jadad評(píng)分示文獻(xiàn)質(zhì)量普遍比較低。Meta-分析結(jié)果示:臨床療效比較的合并效應(yīng)量RR(relative risk)及95%CI為:1.41[1.24,1.61];動(dòng)態(tài)心電圖比較的合并效應(yīng)量RR(relative risk)及95%CI為:2.67[2.05,3.48];平均心率比較的合并效應(yīng)量MD(mean difference)及95%CI為:5.52[2.85,8.19];24h總心率比較的合并效應(yīng)量SMD(standardized mean difference)及95%CI為:0.87[0.50,1.24];最快心率比較的合并效應(yīng)量MD(mean difference)及95%CI為:3.95[-2.53,10.43];最慢心率比較的合并效應(yīng)量MD(mean difference)及95%CI為:2.53[0.07,5.00];竇房結(jié)恢復(fù)時(shí)間(SNRT)比較的合并效應(yīng)量SMD(standardized mean difference)及95%CI為:-0.57[-0.86,-0.27];竇房結(jié)傳導(dǎo)時(shí)間(SACT)比較的合并效應(yīng)量SMD(standardized mean difference)及95%CI為:-1.41[-2.31,-0.51]。2.數(shù)據(jù)挖掘結(jié)果示:使用頻次比較多的藥物類別是補(bǔ)虛藥、溫里藥、解表藥、活血化瘀藥;病態(tài)竇房結(jié)綜合征用藥的主要配伍如下:補(bǔ)氣藥與溫里藥的配伍,解表藥與溫里藥的配伍,以及溫里藥、補(bǔ)虛藥、解表藥的聯(lián)合應(yīng)用。結(jié)論:溫陽(yáng)益氣法治療病態(tài)竇房結(jié)綜合征療效確切,安全性高。數(shù)據(jù)挖掘病態(tài)竇房結(jié)綜合征的用藥特點(diǎn)及配伍規(guī)律,為臨床用藥提供指導(dǎo)。
[Abstract]:Objective: to analyze the literature on the treatment of sick sinus syndrome (SSS) with the method of warming yang and nourishing qi by using the method of systematic evaluation of evidence-based medicine. Based on data mining, this paper explores the characteristics and compatibility of drugs used in the treatment of sick sinus syndrome, and provides a scientific basis and a new way of thinking for the treatment of sick sinus with traditional Chinese medicine. Method 1: 1. Through electronic search and manual retrieval, the clinical randomized controlled trial of warming yang and supplementing qi method for treating sick sinus syndrome was searched, and Jadad scoring standard was used to evaluate the quality of the research literature. Using Revman 5.2 software, the overall effect of multiple research results was analyzed by Meta- analysis and inverted funnel graph analysis. 2. 2. Based on data mining and SPSS 17.0 software for general data processing and frequency analysis, PSS Clementine 12.0 software was selected to analyze association rules and explore the rule of drug use. The result is 1: 1. A total of 16 randomized controlled clinical trials were reviewed. A total of 1181 patients' Jadad scores showed that the quality of literature was generally low. The results of Meta- analysis showed that the combined effects of clinical efficacy comparison were RR (relative risk) and 95 CI were: 1: 1 41 [1. 24 鹵1. 61]; RR (relative risk) and 95 CI compared with dynamic electrocardiogram were 2. 67 [2. 0553. 48]; The combined effects of SMD (standardized mean difference) and 95 CI were 0.87 [0.500.24]; the combined effects of MD (mean difference) and 95CI were 3.95 [-2.5310.43]; the combined effects of the slowest heart rate were 2.53 [0.075.00]; The combined effects of SMD (standardized mean difference) and 95 CI were: -0.57 [-0.86U -0.27], and SMD (standardized mean difference) and 95 CI of sinus node conduction time were: -1.41 [-2.31 鹵0.51] .2. The results of data mining show that the most frequently used drugs are tonifying drugs, warm medicine, antipods, promoting blood circulation and removing blood stasis; the main compatibility of the drugs used in sick sinus syndrome is as follows: the compatibility of tonifying qi medicine with warm medicine, The compatibility of antiepiderms with warm medicine, as well as the combined application of mild medicine, tonifying medicine and antitabular medicine. Conclusion: the therapy of warming yang and nourishing qi is effective and safe in the treatment of sick sinus syndrome. Data mining sick sinoatrial syndrome drug characteristics and compatibility, to provide guidance for clinical use.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259

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