本文選題：壯藥 + 龍船花��； 參考：《廣西中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:對(duì)壯藥龍船花(Ixora chinensis Lam.)和露兜樹(Pandanus tectorius Soland.)的質(zhì)量標(biāo)準(zhǔn)進(jìn)行研究,建立和評(píng)價(jià)龍船花、露兜樹藥材質(zhì)量標(biāo)準(zhǔn)的方法,并制訂壯藥龍船花和露兜樹的質(zhì)量標(biāo)準(zhǔn),為壯藥龍船花和露兜樹的質(zhì)量控制提供科學(xué)的依據(jù)。方法:(1)從龍船花和露兜樹的根或莖橫切面、藥材粉末特征、植物形態(tài)、藥材性狀鑒別等多方面進(jìn)行生藥學(xué)研究;(2)通過(guò)對(duì)藥材的水分測(cè)定,總灰分測(cè)定、酸不溶性灰分測(cè)定及浸出物測(cè)定對(duì)龍船花和露兜樹藥材進(jìn)行檢查項(xiàng)研究;(3)通過(guò)化學(xué)成分預(yù)試驗(yàn),對(duì)龍船花和露兜樹進(jìn)行了化學(xué)成分初步研究;(4)通過(guò)薄層鑒別法對(duì)龍船花和露兜樹藥材進(jìn)行定性鑒別;(5)通過(guò)HPLC對(duì)龍船花中東莨菪內(nèi)酯的含量進(jìn)行測(cè)定;(6)參照2015年版《中華人民共和國(guó)藥典》制訂了壯藥龍船花和露兜樹的藥材質(zhì)量標(biāo)準(zhǔn)(草案)。結(jié)果:(1)生藥學(xué)研究龍船花:莖呈圓柱形,黃褐色,直徑5~8mm,斷面皮部薄,黃褐色或黑褐色,木部灰白色,葉對(duì)生,花序頂生多花。木栓層有數(shù)列厚角組織細(xì)胞,形成層明顯,木質(zhì)部相對(duì)較寬并具有大量木纖維,中央髓部寬廣,有很多大型石細(xì)胞群。氣孔為平軸式,復(fù)粒淀粉粒由2~3個(gè)單粒淀粉粒組成,草酸鈣簇晶和棕色體常見(jiàn),螺紋導(dǎo)管較多,孔溝明顯。露兜樹:根呈圓柱形,棕黃色,直徑3~6mm,皮部皺縮成棱狀突起,葉緣和背面中脈均有粗壯的銳刺,聚花果大,核果束倒圓錐形,質(zhì)堅(jiān)硬。皮部寬廣,有大量纖維束和大型黏液細(xì)胞,內(nèi)皮層明顯,中柱維管束成輻射狀。淀粉粒類圓形,復(fù)粒淀粉粒,草酸鈣針晶較多,常見(jiàn)晶鞘纖維,導(dǎo)管主為螺紋、梯紋、具緣紋孔導(dǎo)管,氣孔平軸式。(2)檢查項(xiàng)龍船花:通過(guò)對(duì)壯藥龍船花10個(gè)不同批號(hào)的樣品進(jìn)行研究,10批樣品水分含量擬訂為不得過(guò)12.0%,總灰分?jǐn)M定為不得過(guò)6.0%,酸不溶性灰分?jǐn)M定為不得過(guò)1.5%,浸出物含量擬訂為不少于13.0%。露兜樹:通過(guò)對(duì)壯藥露兜樹10個(gè)不同批號(hào)的樣品進(jìn)行研究,10批樣品水分含量擬訂為不得過(guò)9.6%,總灰分?jǐn)M定為不得過(guò)8.0%,酸不溶性灰分?jǐn)M定為不得過(guò)2.0%,浸出物含量擬訂為不少于12.5%。(3)化學(xué)成分預(yù)試驗(yàn)龍船花藥材中可能含有糖、多糖、苷類、皂苷、鞣質(zhì)、黃酮類、植物甾醇、三萜類及香豆素類等成分。露兜樹藥材中可能含有糖、多糖、苷類、有機(jī)酸、黃酮類、酚類、香豆素、內(nèi)酯等成分。(4)藥材供試品薄層色譜中,在與對(duì)照藥材色譜相應(yīng)的位置上,顯相同顏色的斑點(diǎn),重現(xiàn)性較好。(5)10批樣品中含量最高的是LCH-2=0.06103mg/g;含量最低的是LCH-3=0.04843mg/g,10批樣品平均含量(0.055415mg/g),降低20%計(jì),擬定壯藥龍船花東莨菪內(nèi)酯含量限度不低于0.044332mg/g(按干燥品計(jì)算,不得少于0.0044332%)。結(jié)論:本文對(duì)龍船花和露兜樹的根或莖橫切面、藥材粉末特征、植物形態(tài)、藥材性狀鑒別的生藥學(xué)研究具有一定意義。通過(guò)薄層鑒定對(duì)龍船花和露兜樹藥材進(jìn)行了定性鑒別。檢查項(xiàng)研究和含量測(cè)定結(jié)果為龍船花和露兜樹藥材質(zhì)量控制提供了評(píng)價(jià)指標(biāo)。參照2015年版《中華人民共和國(guó)藥典》制訂了龍船花和露兜樹的藥材質(zhì)量標(biāo)準(zhǔn)草案,該標(biāo)準(zhǔn)具有科學(xué)性、可行性、實(shí)用性等特點(diǎn),為龍船花和露兜樹藥材質(zhì)量控制提供參考依據(jù)。
[Abstract]:Objective: To study the quality standard of Ixora chinensis Lam. and Pandanus tectorius Soland., to establish and evaluate the quality standard of the Dragon Boat flower and the crude drug, and to establish the quality standard of the Dragon Boat flower and the drive tree of the strong medicine, and provide the scientific basis for the quality control of the Dragon Boat flower and the radix Acacus. Methods: (1) the study of Pharmacognosy from the root or stem of the dragon boat and the root or stem of the tree, the characteristics of the medicinal powder, the plant morphology, the identification of the medicinal properties, and so on. (2) the determination of the moisture of the medicinal materials, the determination of the total ash, the determination of acid insoluble ash and the determination of the extracts of the extract on the medicinal herbs of the dragon boat and the radix acacinus; (3) through chemical formation. Preliminary study on the chemical composition of dragon boat flower and Lusa tree; (4) qualitative identification of dragon boat flower and Radix acurus by TLC identification; (5) the content of scopolamine in Dragon Boat flower was measured by HPLC; (6) according to the 2015 edition of People's Republic of China Pharmacopoeia, the drug of Dragon Boat flower and luschini tree was formulated. Material quality standard (Draft). Results: (1) pharmacognosy study Dragon Boat flower: the stem is cylindrical, yellow brown, 5~8mm diameter, the skin of the section is thin, yellow brown or black brown, the wood is gray, the leaf is green and the inflorescence is most flower. The cork layer has a number of thick angle tissue cells, the formation layer is obvious, the xylem is relatively wide and has a large number of wood fiber, the central pith is broad, the central pith is broad, central pulp. There are a lot of large stone cell groups. The stoma is a horizontal axis. The starch granules are composed of 2~3 single starch granules. The calcium oxalate clusters and brown bodies are common, the threaded ducts are more and the groove is obvious. The roots show a cylindrical, brown yellow, 3~6mm diameter, and the skin shrinks in the prismatic protuberance. The leaf margin and the back of the middle vein have strong sharp spines, large PPS, and Ribas. The beam is conical and hard. The skin is broad and broad, with a large number of fiber bundles and large mucous cells. The endothelial layer is obvious. The vascular bundle of the middle column is radiated. The starch granules are round, the starch granules, the calcium oxalate needle are more, the common crystal sheath fiber, the main thread of the duct, the ladder and the stomata flat axis. (2) check the Dragon Boat flower: through the Zhuang Medicine 10 samples of different batch numbers of the dragon boat were studied. The water content of the 10 batches was drawn up to no more than 12%, the total ash was drawn up to not over 6%, the acid insoluble ash was drawn up to no more than 1.5%, the content of the extract was not less than the 13.0%. tree: the samples of 10 different batch numbers of the strong drug Bib tree were studied and the moisture of the 10 batch of samples was found. The content is not over 9.6%, the total ash can not be over 8%, acid insoluble ash is drawn up to not over 2%, the content of extract is not less than 12.5%. (3) chemical composition pretest Dragon Boat flower medicinal herbs may contain sugar, polysaccharide, glycosides, tannins, Huang Tong, phytosterols, three terpenoids and coumarins. It may contain sugar, polysaccharides, glycosides, organic acids, flavonoids, phenols, coumarins, lactone and other components. (4) in the thin layer chromatography of drug supply samples, the same color spots and reproducibility are found in the corresponding location of the drug chromatography. (5) the highest content of the 10 batches is LCH-2=0.06103mg/g; the lowest content is LCH-3=0.04843mg/g, 10 batches. The average content of the sample (0.055415mg/g) was reduced by 20%, and the limit of the content of scopolamine was not less than 0.044332mg/g (no less than 0.0044332%). Conclusion: the Pharmacognosy study of the root or stem transverse section of the Dragon Boat flower and the rhizome of the rhizome of the dragon boat, the characteristics of medicinal powder, plant morphology and the identification of medicinal properties The qualitative identification was carried out by TLC identification. The results of examination and content determination provided the evaluation index for the quality control of the Dragon Boat flower and the Chinese medicinal herb. According to the 2015 edition of the People's Republic of China Pharmacopoeia, the draft quality standard of the Dragon Boat flower and the wild tree was formulated. The characteristics of learning, feasibility and practicability provide reference for quality control of medicinal materials of dragon boat flower and wild flower tree.
【學(xué)位授予單位】：廣西中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R29

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