本文選題：哮喘-慢阻肺重疊綜合征 + 陽(yáng)和平喘顆粒　； 參考：《安徽中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的初步觀察ACOS中醫(yī)證候分布特點(diǎn);陽(yáng)和平喘顆粒治療ACOS非緩解期患者的臨床療效及對(duì)血清炎癥因子IL-4、IFN-γ、IL-8、IL-10的影響。方法1采用橫斷面調(diào)查方法,填寫ACOS中醫(yī)證候觀察表,對(duì)ACOS中醫(yī)證候分布特點(diǎn)進(jìn)行初步的臨床觀察。2收集符合納入標(biāo)準(zhǔn)的40例ACOS患者,隨機(jī)分配到治療組和對(duì)照組,每組各20例。對(duì)照組以常規(guī)西醫(yī)治療為主,治療組在對(duì)照組的基礎(chǔ)上加用陽(yáng)和平喘顆粒治療。觀察兩組患者治療前后中醫(yī)證候積分、肺功能指標(biāo)(FEV1、FVC、FEV1/FVC及FEV1%預(yù)計(jì)值)、血清炎癥因子(IL-4、IFN-γ、IL-8及IL-10)和生活質(zhì)量評(píng)分的變化。結(jié)果1 ACOS中醫(yī)證候初步觀察ACOS發(fā)病以男性居多,吸煙史較長(zhǎng),誘發(fā)本病發(fā)作的因素以氣候變化為甚,肺功能分級(jí)在重度以上者占82.5%;以咳嗽、咳痰、胸悶所占頻數(shù)最多是本病的主癥;中醫(yī)證型以熱證居多,其中熱夾痰證最多,其次是熱夾瘀證,再者是寒夾虛證。2陽(yáng)和平喘顆粒對(duì)ACOS非緩解期患者中醫(yī)證候積分的影響兩組治療前中醫(yī)證候積分比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);兩組治療后中醫(yī)證候積分較治療前均明顯降低(P0.01)。治療組治療后中醫(yī)證候積分與對(duì)照組治療后比較差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療組中醫(yī)證候療效(85%)高于對(duì)照組(60%)差異有統(tǒng)計(jì)學(xué)意義(P0.05)。3陽(yáng)和平喘顆粒對(duì)ACOS非緩解期患者肺功能的影響兩組治療前FVC、FEV1、FEV1%預(yù)計(jì)值及FEV1/FVC比較差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。治療后兩組FVC、FEV1、FEV1%預(yù)計(jì)值及FEV1/FVC較治療前均升高(P0.01或P0.05)。治療組治療后FVC、FEV1、FEV1%預(yù)計(jì)值及FEV1/FVC與對(duì)照組治療后比較差異有統(tǒng)計(jì)學(xué)意義(P0.05)。4陽(yáng)和平喘顆粒對(duì)ACOS非緩解期患者血清指標(biāo)的影響兩組治療前血清IL-4、IFN-γ、IL-8及IL-10水平比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。治療后兩組血清IL-4、IL-8水平較治療前均降低(P0.01或P0.05),血清IFN-γ、IL-10水平較治療前均升高(P0.01或P0.05)。治療組治療后血清IL-4、IFN-γ、IL-8及IL-10水平與對(duì)照組治療后比較差異有統(tǒng)計(jì)學(xué)差異(P0.05)。5陽(yáng)和平喘顆粒對(duì)ACOS非緩解期患者生活質(zhì)量評(píng)分的影響兩組治療前CAT評(píng)分比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);兩組治療后CAT評(píng)分較治療前均降低(P0.01);治療組治療后CAT評(píng)分與對(duì)照組治療后比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),但治療組下降更明顯。結(jié)論1在40例ACOS患者中,中醫(yī)證型以熱證居多,虛、瘀、痰是重要的兼證。2陽(yáng)和平喘顆粒在西醫(yī)治療的基礎(chǔ)上可提高ACOS非緩解期患者的中醫(yī)證候積分、生活質(zhì)量評(píng)分,改善患者的肺功能。3陽(yáng)和平喘顆粒在西醫(yī)治療的基礎(chǔ)上能降低ACOS非緩解期患者血清炎癥因子IL-4、IL-8水平,升高IFN-γ、IL-10水平。
[Abstract]:Objective to observe the distribution of TCM syndromes of ACOS, the clinical effect of Yanghe Pingchuan granule on non-remission ACOS patients and the influence of IL-4, IFN- 緯, IL-8 and IL-10 on serum inflammatory factor IL-4, IFN- 緯, IL-8 and IL-10 in patients with ACOS. Methods 1 A cross-sectional investigation was used to fill out the observation form of TCM syndrome of ACOS. The clinical observation of the distribution of TCM syndromes of ACOS was carried out. 2. 40 ACOS patients who met the inclusion criteria were randomly assigned to the treatment group and the control group. There were 20 cases in each group. The control group was treated mainly by routine western medicine, and the treatment group was treated with Yang and Pingchuan granules on the basis of the control group. The scores of TCM syndromes, pulmonary function indexes, FEV1 / FVC and FEV1% predicted values, serum inflammatory factors (IL-4, IFN- 緯, IL-8 and IL-10) and quality of life (QOL) were observed before and after treatment in both groups. Results 1 Primary observation of TCM syndromes of ACOS showed that the incidence of ACOS was mostly male, smoking history was longer, the factors inducing ACOS attack were climate change, 82.5% of the patients with severe grade of lung function were cough, sputum, cough, phlegm, and so on. The frequency of chest tightness is the main symptom of the disease, heat syndrome is the most common type of TCM syndromes, among which heat clamping phlegm syndrome is the most, followed by heat and stasis syndrome. Furthermore, there was no significant difference in TCM syndromes score between the two groups before treatment (P 0.05N), and after treatment, the TCM syndrome score of the two groups were significantly lower than that of the control group (P 0.01). 2. The effect of Han Jia deficiency Syndrome on TCM syndromes integral in patients with ACOS during non-remission period was not statistically significant (P0.05N), and the scores of TCM syndromes after treatment in two groups were significantly lower than those before treatment. The scores of TCM syndrome in the treatment group were significantly different from those in the control group (P 0.05). The effect of TCM syndromes in the treatment group (85) was higher than that in the control group (60). There was no significant difference in the effect of P0.050.3-Yang and Pingchuan granule on lung function of patients with ACOS during non-remission period before treatment. There was no significant difference in the predicted value of FEV1 / FEV1 and FEV1 / FVC before treatment between the two groups. After treatment, the predicted FEV1 / FEV1% and FEV1 / FVC in both groups were significantly higher than those before treatment (P0.01 or P0.05). There was significant difference in the predicted value of FEV1 / FEV1% and the difference of FEV1 / FVC between the treatment group and the control group after treatment. The effect of P0.05.4 Yang and Pingchuan granule on serum indexes of patients with ACOS during non-remission period had no significant difference between the two groups before treatment. There was no significant difference in the levels of IL-4 IFN- 緯 -IL-8 and IL-10 between the two groups before treatment. After treatment, the serum levels of IL-4, IL-8 and IFN- 緯 -IL-10 in both groups were lower than those before treatment, respectively, and the levels of serum IFN- 緯 -IL-10 were higher than those before treatment (P0.01 or P0.05). Effect of serum IL-4, IFN- 緯 -IL-8 and IL-10 levels after treatment on quality of life score of non-remission ACOS patients in the treatment group and control group, there was no significant difference between the two groups in terms of cat score before treatment. The cat score of the treatment group was lower than that of the control group, but the cat score of the treatment group was lower than that of the control group, but the decrease of the cat score in the treatment group was more obvious than that in the control group. Conclusion (1) in 40 patients with ACOS, heat syndrome, deficiency, blood stasis and phlegm are the most important syndromes in 40 patients with ACOS. On the basis of western medicine treatment, the TCM syndromes integral and quality of life score of ACOS patients with non-remission period can be improved. On the basis of western medicine treatment, the improvement of pulmonary function in patients with ACOS can reduce the level of IL-4 and IL-8, and increase the level of IFN- 緯 -IL-10 in patients with ACOS.
【學(xué)位授予單位】：安徽中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 李廷謙,黃素珍,王偉明,夏慶,張敏,雷幼導(dǎo);冠元顆粒治療慢性肺心病緩解期患者的療效觀察[J];中藥藥理與臨床;1993年04期

2 段勵(lì)夫;慢性阻塞性肺疾病緩解期患者抑郁和焦慮表現(xiàn)與社會(huì)支持的相關(guān)性分析[J];中國(guó)臨床康復(fù);2004年06期

3 韋春萍;;慢性阻塞性肺疾病緩解期患者的健康教育及康復(fù)鍛煉[J];護(hù)理實(shí)踐與研究;2007年01期

4 李萍;運(yùn)動(dòng)加肺功能訓(xùn)練對(duì)慢性阻塞性肺疾病緩解期患者肺功能的改善[J];中國(guó)臨床康復(fù);2002年17期

5 蔡映云,徐京,柳啟沛,傅穎,鈕善福;飲食補(bǔ)充對(duì)慢性阻塞性肺疾病緩解期患者營(yíng)養(yǎng)狀況等的影響[J];中華結(jié)核和呼吸雜志;1996年02期

6 崔朝勃,李煜,田振甲,王東梅,張穎軒,王思勤,蔡柏薔;夜間無(wú)創(chuàng)傷通氣在慢性阻塞性肺疾病緩解期患者中的應(yīng)用[J];中國(guó)航天工業(yè)醫(yī)藥;2000年02期

7 洪榮梅;何永蓮;鄭冬杏;陳冬梅;;有氧運(yùn)動(dòng)對(duì)老年慢性阻塞性肺疾病緩解期患者疲乏狀況的影響[J];護(hù)士進(jìn)修雜志;2011年09期

8 顧宇彤,蔡映云,柳啟沛,雷光浦;慢阻肺緩解期患者營(yíng)養(yǎng)不良及其相關(guān)因素分析[J];中國(guó)康復(fù)醫(yī)學(xué)雜志;1997年06期

9 馬加,袁開芬,溫林俏,金偉秋,趙國(guó)厚,李雯珠;慢阻肺緩解期患者肺功能與體重及血清補(bǔ)體的相關(guān)分析[J];臨床薈萃;2001年09期

10 賀玉蘭,賀成芳,朱倩;慢性肺源性心臟病緩解期患者的自理指導(dǎo)[J];河北中醫(yī);2001年01期

相關(guān)會(huì)議論文 前8條

1 孫素珍;;精神分裂癥緩解期患者的孤獨(dú)感及社會(huì)支持狀況的研究[A];河南省精神科護(hù)理風(fēng)險(xiǎn)管理培訓(xùn)班及學(xué)術(shù)交流會(huì)資料匯編[C];2011年

2 嚴(yán)芳;孫素珍;李栓榮;;精神分裂癥緩解期患者的孤獨(dú)感及社會(huì)支持狀況的研究[A];2011年河南省護(hù)理健康教育新進(jìn)展學(xué)術(shù)交流暨高級(jí)研修班論文集[C];2011年

3 趙明華;海迪婭·艾爾肯;孜比爾;韓克斯;馬巖霞;徐春蓮;;COPD患者短期住院干預(yù)治療療效分析[A];中華醫(yī)學(xué)會(huì)呼吸病學(xué)年會(huì)——2011（第十二次全國(guó)呼吸病學(xué)學(xué)術(shù)會(huì)議）論文匯編[C];2011年

4 嚴(yán)芳;;精神分裂癥緩解期患者的孤獨(dú)感及社會(huì)支持狀況的研究[A];精神科護(hù)理新進(jìn)展培訓(xùn)班及學(xué)術(shù)研討會(huì)論文集[C];2008年

5 崔小川;王紅梅;周敏;陳志萍;袁民宇;錢秀芬;;COPD緩解期患者夜間低通氣的臨床觀察[A];2006年中國(guó)睡眠研究會(huì)第四屆學(xué)術(shù)年會(huì)論文摘要匯編[C];2006年

6 姜國(guó)偉;;慢性阻塞性肺疾病急性發(fā)作期及緩解期患者血清IFN-γ、IL-4水平變化及臨床意義[A];中華醫(yī)學(xué)會(huì)呼吸病學(xué)年會(huì)——2013第十四次全國(guó)呼吸病學(xué)學(xué)術(shù)會(huì)議論文匯編[C];2013年

7 王謙;展鳳霞;侯明;陸楠;;IL-18/IL-18R在免疫性血小板減少癥患者發(fā)病機(jī)制中的價(jià)值[A];中華醫(yī)學(xué)會(huì)第七次全國(guó)中青年檢驗(yàn)醫(yī)學(xué)學(xué)術(shù)會(huì)議論文匯編[C];2012年

8 張?chǎng)?陳文華;吳衛(wèi)青;郝立爽;郁鄢鄢;;醫(yī)療體操對(duì)緩解期COPD患者康復(fù)療效探討[A];中國(guó)康復(fù)醫(yī)學(xué)會(huì)全國(guó)運(yùn)動(dòng)療法學(xué)術(shù)會(huì)議暨心腦血管病康復(fù)研討班論文匯編[C];2000年

相關(guān)碩士學(xué)位論文 前1條

1 張秋萍;ACOS中醫(yī)證候初步觀察及陽(yáng)和平喘顆粒對(duì)ACOS非緩解期患者干預(yù)作用[D];安徽中醫(yī)藥大學(xué);2016年

，

本文編號(hào)：2027402