本文選題：功能性消化不良 + 脾胃虛寒型��； 參考：《廣西中醫(yī)藥大學》2017年碩士論文

【摘要】：目的:本研究通過觀察溫陽和胃方對脾胃虛寒型功能性消化不良的臨床療效、安全性以及對胃動素水平的變化,為中醫(yī)藥治療功能性消化不良提供新的思路和方法。方法:本研究采用隨機對照的研究方法,將符合納入標準的功能性消化不良患者82例隨機分為治療組和對照組,每組各41例。治療組服用溫陽和胃方治療,對照組服用枸櫞酸莫沙必利片和雷貝拉唑鈉腸溶片治療,兩組療程均為4周。觀察兩組治療前后中醫(yī)癥候、生存質(zhì)量以及胃動素水平變化情況。采用SPASS17.0統(tǒng)計軟件統(tǒng)計分析。結(jié)果:剔除脫落病例3例,共完成觀察病例79例,其中治療組40例,對照組39例。1.臨床整體療效比較:治療后,治療組總有效率為92.50%,對照組總有效率為74.36%,治療組總有效率明顯高于對照組(P0.05)。2.中醫(yī)癥候積分比較:治療后,治療組各癥狀較治療前均有明顯改善(P0.05);對照組胃脘疼痛、胃脘脹悶、泛吐清水、食少納呆癥狀較治療前好轉(zhuǎn)(P0.05),其他癥狀未見好轉(zhuǎn);與對照組比較,治療組除胃脘疼痛、泛吐清水癥狀外,其他癥狀改善均優(yōu)于對照組(P0.05)。3.FDDQL比較:治療后,治療組在改善日常生活、憂慮、睡眠、不適、健康感覺、壓力方面均明顯優(yōu)于對照組(P0.05);在改善飲食、疾病控制方面兩組療效相當(P0.05)。4.血漿胃動素比較:治療后兩組血漿胃動素水平均較治療前升高,差異有統(tǒng)計學意義(P0.05);治療后組間比較,治療組血漿胃動素水平明顯高于對照組,差異有統(tǒng)計學意義(P0.05)。5.復(fù)發(fā)率比較:治療組復(fù)發(fā)率為16.22%,對照組復(fù)發(fā)率為41.38%,治療組復(fù)發(fā)率明顯低于對照組(P0.05)。6.安全性指標:兩組患者在治療期間均未發(fā)生不良反應(yīng)。結(jié)論:1.溫陽和胃方治療脾胃虛寒型功能性消化不良的臨床療效確切,能提高患者生存質(zhì)量,且復(fù)發(fā)率低,未發(fā)現(xiàn)不良反應(yīng),安全性好,值得臨床推廣應(yīng)用。2.溫陽和胃方治療脾胃虛寒型功能性消化不良的作用機制可能與胃動素水平升高有關(guān)。
[Abstract]:Objective: to observe the clinical efficacy, safety and changes of motilin level of Wenyang Hewei recipe in the treatment of functional dyspepsia with deficiency of spleen and stomach, and to provide a new way of thinking and method for the treatment of functional dyspepsia with traditional Chinese medicine. Methods: 82 patients with functional dyspepsia were randomly divided into treatment group and control group with 41 cases in each group. The treatment group was treated with Wenyang and Wei decoction, the control group was treated with mosapride citrate tablets and rabeprazole enteric coated tablets. The course of treatment in both groups was 4 weeks. The changes of TCM symptoms, quality of life and motilin level before and after treatment were observed. SPASS17.0 statistical software was used for statistical analysis. Results: three cases were excluded and 79 cases were observed, including 40 cases in the treatment group and 39 cases in the control group. Comparison of the overall clinical efficacy: after treatment, the total effective rate of the treatment group was 92.50 and the total effective rate of the control group was 74.36. The total effective rate of the treatment group was significantly higher than that of the control group (P 0.05). Comparison of TCM symptom score: after treatment, the symptoms in the treatment group were significantly improved compared with those before treatment; in the control group, the symptoms of epigastric pain, distention and boredom were significantly improved; in the control group, the symptoms of stomach ache, distension, vomiting and dyspnea were improved compared with those before treatment, but the other symptoms were not improved; compared with the control group, The improvement of other symptoms in the treatment group was better than that in the control group (P 0.05). 3. Comparison of FDDQL: after treatment, the treatment group improved daily life, anxiety, sleep, discomfort and health feeling. Stress was significantly better than that of control group (P 0.05), and the effect of two groups on improving diet and disease control was similar to that of control group (P 0.05). Comparison of plasma motilin: after treatment, the plasma motilin level of the two groups was higher than that before treatment, the difference was statistically significant (P 0.05), and after treatment, the plasma motilin level of the treatment group was significantly higher than that of the control group, and the difference was statistically significant. The recurrence rate of the treatment group was 16.22 and that of the control group was 41.38. The recurrence rate of the treatment group was significantly lower than that of the control group. Safety index: there was no adverse reaction during treatment in both groups. Conclusion 1. The clinical effect of Wenyang Hewei recipe in treating functional dyspepsia with deficiency of spleen and stomach is definite, it can improve the quality of life of the patients, and the recurrence rate is low, no adverse reactions are found, and the safety is good. It is worth popularizing and applying in clinic. The mechanism of Wenyang Hewei recipe in treating functional dyspepsia with deficiency of spleen and stomach may be related to the increase of motilin level.
【學位授予單位】：廣西中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R259

【參考文獻】

相關(guān)期刊論文 前10條

1 張玉梅;劉渝冊;;六味能消膠囊聯(lián)合氟哌噻噸美利曲辛治療功能性消化不良的臨床研究[J];遼寧中醫(yī)雜志;2017年02期

2 俞惠達;;針刺配合艾箱灸治療脾胃虛寒型功能性消化不良臨床研究[J];亞太傳統(tǒng)醫(yī)藥;2017年03期

3 高飛;;莫沙必利聯(lián)合復(fù)方阿嗪米特治療功能性消化不良的臨床療效[J];醫(yī)學理論與實踐;2017年01期

4 周斌;王飛龍;張軍;;探討質(zhì)子泵抑制劑埃索美拉唑與莫沙必利聯(lián)合治療功能性消化不良的臨床療效[J];醫(yī)學理論與實踐;2016年18期

5 李學軍;江應(yīng)露;劉禮梅;陳亮亮;金月萍;吳婧;;脾胃培源散穴位外敷治療脾胃虛寒型功能性消化不良療效及對血清MTL的影響[J];國醫(yī)論壇;2016年05期

6 許建軍;李雪波;劉靜;杜其梅;李冬梅;;穴位貼敷療法治療功能性消化不良臨床療效觀察[J];中醫(yī)外治雜志;2016年04期

7 劉倩倩;湯紹輝;;抗焦慮或抗抑郁藥輔助治療功能性消化不良療效的Meta分析[J];疑難病雜志;2016年08期

8 韓佰南;;幽門螺桿菌根除治療對幽門螺桿菌陽性的功能性消化不良患者的質(zhì)量效果[J];中國婦幼健康研究;2016年S2期

9 彭坤明;羅鵬;;針灸治療功能性消化不良伴情緒障礙療效觀察[J];針灸臨床雜志;2016年06期

10 徐廣鑫;;四磨湯治療功能性消化不良療效觀察[J];亞太傳統(tǒng)醫(yī)藥;2016年11期

相關(guān)碩士學位論文 前1條

1 蔡強;武漢市成人胃腸疾病流行病學調(diào)查研究[D];華中科技大學;2008年

，

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