本文選題：補(bǔ)腎調(diào)周法　切入點(diǎn)：復(fù)發(fā)性流產(chǎn)　出處：《南京中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：觀察中醫(yī)補(bǔ)腎調(diào)周法治療封閉抗體不足性復(fù)發(fā)性流產(chǎn)的臨床療效,并探討其作用機(jī)理,為日后臨床推廣以及應(yīng)用提供依據(jù)。方法：收集符合納入標(biāo)準(zhǔn)的封閉抗體不足性復(fù)發(fā)性流產(chǎn)非妊娠期患者30例(證屬脾腎兩虛),予補(bǔ)腎調(diào)周中藥序貫口服,3個(gè)月1個(gè)療程,共兩個(gè)療程。觀察：1.治療后臨床癥狀、體征改善情況；2.治療后血封閉抗體變化情況;3.治療后血Th1 (IL-8)、Th2 (IL-6)細(xì)胞因子及Th1(IL-8)/Th2 (IL-6)水平的變化；4.治療后患者的妊娠情況。結(jié)果：1、補(bǔ)腎調(diào)周法不僅能顯著改善患者的臨床證候,還可有效提高患者外周血抗CD3-BE、抗CD8-BE的陽(yáng)性率,降低IL-8水平和IL-8/IL-6比值,升高外周血IL-6水平,但對(duì)抗CD4-BE無(wú)明顯影響。以上免疫指標(biāo)于治療前后相比較,P均0.05,有統(tǒng)計(jì)學(xué)意義。2、兩個(gè)療程后,30例患者中有7例再次妊娠,其中,6例獲得成功,1例再次流產(chǎn),妊娠成功率為20%。3、本課題30例患者經(jīng)治療,6例痊愈,占20%；18例顯效,占60%；5例有效,占16.7%；總有效率96.7%。結(jié)論：補(bǔ)腎調(diào)周法治療封閉抗體不足性復(fù)發(fā)性流產(chǎn)療效確切,既可雙向調(diào)節(jié)人的免疫功能,促進(jìn)外周血抗CD3-BE和抗CD8-BE轉(zhuǎn)陽(yáng),減少Thl細(xì)胞因子的分泌,促進(jìn)Th2細(xì)胞因子的釋放,調(diào)節(jié)Th1/Th2,促進(jìn)同種免疫耐受的建立,又能顯著減輕患者脾腎兩虛的病候,改善妊娠結(jié)局,而且用藥相對(duì)安全,易于患者接受,在同種免疫型復(fù)發(fā)性流產(chǎn)的防治中具有廣闊的應(yīng)用前景。
[Abstract]:Objective: To observe the clinical curative effect of traditional Chinese medicine Bushen Tiaozhou therapy blocking antibody deficiency of recurrent spontaneous abortion, and to explore its mechanism, provide the basis for clinical promotion and application after. Methods: We collected in accordance with the inclusion criteria of blocking antibody deficiency of recurrent spontaneous abortion (30 cases of patients with non pregnancy syndrome is the spleen kidney two falsely) for traditional Chinese medicine Bushen Tiaozhou, sequential oral, 3 months of 1 courses, a total of two courses: 1.. Observation after treatment, clinical symptoms, signs of improvement after treatment; 2. blood blocking antibody changes; 3. after treatment, blood Th1 (IL-8), Th2 (IL-6) cytokines and Th1 (IL-8) /Th2 (IL-6) level changes; pregnancy in 4. after treatment. Results: 1, the clinical syndrome of tkrpm can significantly improve the patients, but also can effectively improve the blood anti CD3-BE patients, the positive rate of CD8-BE, decrease the level of IL-8/IL-6 and the ratio of IL-8, the increase of IL in peripheral blood The level of -6, but no significant effect against CD4-BE. The above immune indexes before and after treatment comparison, P was 0.05,.2 was statistically significant, after two month treatment, 30 cases in 7 cases of pregnancy, among them, 6 were successful, 1 cases of abortion, pregnancy success rate is 20%.3, this topic 30 cases were cured, 6 cases were cured, accounting for 20%; 18 cases were cured, accounting for 60%; 5 cases were effective, accounting for 16.7%; the total efficiency was 96.7%. conclusion: the curative effect in the treatment of recurrent spontaneous abortion by blocking antibody deficiency the exact method of invigorating kidney and regulating menstruation, immune function can promote the two-way regulation of the peripheral blood and anti CD3-BE anti CD8-BE seroconversion, reduce the secretion of Thl cytokines, Th2 promotes the release of cytokines, regulate Th1/Th2, promote the establishment of immune tolerance, and can significantly reduce the symptoms of patients with spleen and kidney two empty, improve the outcome of pregnancy, and the medication is relatively safe and is easily accepted by patients, in alloimmune recurrent flow The prevention and control of production has a broad application prospect.

【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R271.9

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