本文選題：和血除濕湯　切入點：濕疹　出處：《北京中醫(yī)藥大學》2017年碩士論文　論文類型：學位論文

【摘要】：目的:濕疹是一種臨床常見的皮膚病,其皮損表現(xiàn)多樣化,可發(fā)生在體表全身各部位,具有瘙癢、反復發(fā)作的特點,對患者的生活質(zhì)量具有很大的影響,本試驗研究觀察和血除濕湯內(nèi)服干預血虛風燥型濕疹的臨床療效,為和血除濕湯治療血虛風燥型濕疹的療效及安全性提供較高等級證據(jù),為血虛風燥型濕疹之中醫(yī)藥療法提供一個有效可行的方劑和臨床應用提供支撐。研究方法:對符合血虛風燥型濕疹診斷標準的60例研究對象,用Excel按1:1隨機數(shù)字表法分為兩組,進行隨機對照研究。治療組給予和血除濕湯(段行武教授經(jīng)驗方,東直門醫(yī)院顆粒沖劑)口服,每次1袋,每日2次;對照組給予潤燥止癢膠囊(貴州同濟堂制藥),每次4粒,每日3次;兩組患者外治法相同,均采用青鵬軟膏(通天河藏藥制藥)外涂,每日2次。于初診、2周、4周觀察并記錄患者情況。觀察指標:濕疹面積及嚴重度指數(shù)(EASI),瘙癢程度,患者生活質(zhì)量評分(DLQI)及藥物不良反應。結(jié)果:本次60例研究對象,不分組統(tǒng)計,男性共28位,女性共32位,總平均年齡在42±9歲之間,其中患病率最高的年齡段在40-49歲之間,占總數(shù)43%,患病率最低的年齡階段在18-29歲之間,共有7位占總數(shù)12%,;平均病程為17±6個月,最短病程6個月,最長36個月。經(jīng)4周治療后,兩組的皮損面積和嚴重程度(EASI)與治療前相比皆有明顯改善(P0.05),但兩組之間對比無顯著差異(P0.05),治療組總有效率為86%,對照組總有效率為53%;瘙癢程度和患者生活質(zhì)量(DLQI)方面與治療前相比,兩組治療后皆有明顯改善(P0.05),且治療組優(yōu)于對照組(P0.05)。結(jié)論:和血除濕湯,對于血虛風燥型濕疹的皮損面積及嚴重程度(EASI),瘙癢程度和改善生活質(zhì)量具有確切療效,且無明顯不良反應。應用和血除濕湯內(nèi)服治療血虛風燥型濕疹具有可行性。
[Abstract]:Objective: eczema is a common skin disease in clinic. Eczema can occur in various parts of the body surface with the characteristics of pruritus and repeated attacks, which has great influence on the quality of life of patients. This study was to observe the clinical efficacy of Hexue dehumidification decoction in treating eczema with blood deficiency and wind dryness, and to provide high grade evidence for the efficacy and safety of Hexue dehumidification decoction in treating eczema of blood deficiency wind dryness type. Methods: 60 cases of eczema with blood deficiency wind dryness type were divided into two groups by Excel according to 1: 1 random digital table. The treatment group was given Hexue dehumidification decoction (Professor Duan Xingwu experiential prescription, Dongzhimen Hospital granule granule), 1 bag per time, twice a day, while the control group was given Runzao Zhiyang capsule (Guizhou Tongjitang Pharmacy, 4 capsules per time, The two groups were treated with Qingpeng ointment (Tongtianhe Tibetan medicine) twice a day. The patients were observed and recorded in the first visit for 2 weeks and 4 weeks. The outcome measures: eczema area and severity index (EASI), degree of pruritus, degree of pruritus, Results: in this study, there were 28 males and 32 females, the average age was 42 鹵9 years, and the highest prevalence rate was between 40 and 49 years old. The lowest prevalence rate was between 18 and 29 years old, and there were 7 patients who accounted for 12 of the total. The average course of disease was 17 鹵6 months, the shortest course was 6 months, and the longest was 36 months. After 4 weeks of treatment, the average course of disease was 17 鹵6 months and the longest was 36 months. The area and severity of skin lesions in the two groups were significantly improved compared with those before treatment, but there was no significant difference between the two groups. The total effective rate in the treatment group was 86 and the total effective rate in the control group was 533.The degree of pruritus and the quality of life of the patients were treated with DLQI prescription. Compared with before treatment, The treatment group was superior to the control group (P 0.05). Conclusion: Hexue dehumidification decoction has definite curative effect on the area and severity of eczema of blood deficiency and wind dryness type, pruritus degree and improvement of quality of life. There was no obvious adverse reaction. It was feasible to use Hexue dehumidification decoction to treat eczema of blood deficiency and wind dryness type.
【學位授予單位】：北京中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R275.9

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