本文關(guān)鍵詞： 調(diào)脂和血顆粒 動脈粥樣硬化 易損斑塊 二級預(yù)防　出處：《山東中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:通過文獻(xiàn)及臨床研究,探討調(diào)脂和血顆粒對動脈粥樣硬化易損斑塊的臨床干預(yù)效果,從而為化濁行血法治療中風(fēng)病痰瘀阻絡(luò)證提供理論和臨床支持。方法:1.理論探討:廣泛搜集、整理古今醫(yī)家關(guān)于血濁理論的論述,搜集當(dāng)代學(xué)者關(guān)于血濁與易損斑塊及中風(fēng)痰瘀阻絡(luò)證相關(guān)性的試驗(yàn)及理論研究成果,并在此基礎(chǔ)上提出化濁行血治法,闡明血濁理論的內(nèi)涵、病機(jī)及治療原則。2.臨床研究:將62例符合納入標(biāo)準(zhǔn)的缺血性卒中患者隨機(jī)分為觀察試驗(yàn)組(給予阿司匹林腸溶片100mg/次,1次/日;阿托伐他汀鈣片20mg/次,1次/日;調(diào)脂和血顆粒6g/次,3次/日)和對照組(給予阿司匹林腸溶片100mg/次,1次/日;阿托伐他汀鈣片20mg/次,1次/日),通過3個月治療,對比兩組試驗(yàn)對象治療前后療效、實(shí)驗(yàn)室指標(biāo)等變化,分析臨床療效。采用統(tǒng)計軟件SPSS17.0處理分析數(shù)據(jù)。結(jié)果:兩種治療方案對動脈硬化易損斑塊都有較高療效,總有效率觀察試驗(yàn)組為93%,對照組為83%,觀察試驗(yàn)組治療效果比對照組好。中醫(yī)臨床證候積分比較,觀察試驗(yàn)組療效比對照組更好,有統(tǒng)計學(xué)意義(P0.05);在改善中醫(yī)臨床證候積分方面,觀察試驗(yàn)組優(yōu)于對照組,有顯著差異(P0.01)。比較試驗(yàn)前后兩組患者頸動脈超聲,觀察試驗(yàn)組對改善患者斑塊有顯著作用,統(tǒng)計學(xué)有顯著差異(P0.01),觀察試驗(yàn)組卒中的復(fù)發(fā)及進(jìn)展腦梗死率低于對照組,差異具有統(tǒng)計學(xué)意義。結(jié)論:調(diào)脂和血顆粒聯(lián)合西藥常規(guī)治療動脈粥樣硬化易損斑塊比單純西藥治療效果更顯著,能較大程度上改善臨床癥狀,是臨床治療存在易損斑塊缺血性卒中患者的有效臨床途徑。
[Abstract]:Objective: to investigate the clinical intervention effect of Tiaozhi and Xue granule on atherosclerotic vulnerable plaque through literature and clinical research. Thus, it provides theoretical and clinical support for the treatment of phlegm and blood stasis syndrome of apoplexy. Methods: 1. Theoretical discussion: extensive collection, collation of ancient and modern physicians on the theory of blood turbidity. Collection of contemporary scholars on the relationship between blood turbidity and vulnerable plaque and apoplexy phlegm and blood stasis syndrome related to the experimental and theoretical research, and on the basis of the proposed method of blood treatment, to clarify the connotation of the theory of blood turbidity. Clinical study: 62 patients with ischemic stroke who met the inclusion criteria were randomly divided into the observation group (100 mg / d aspirin enteric-coated tablets once a day); The calcium tablets of Atto vastatin were 20mg / day; Tiaozhi Hexue granule (6g / d) and control group (100mg / d aspirin enteric-coated tablets were given once a day); Atto vastatin calcium tablets were treated once a day with 20mg / d for 3 months. The efficacy and laboratory indexes were compared between the two groups before and after treatment. Analysis of clinical efficacy. The statistical software SPSS17.0 was used to process the analysis data. Results: both of the two treatment regimens had higher curative effect on arteriosclerotic vulnerable plaque, the total effective rate was 93% in the experimental group. The therapeutic effect of the observation group was better than that of the control group, and the curative effect of the observation group was better than that of the control group (P 0.05). In improving the TCM clinical syndrome score, the observation group is better than the control group, there is a significant difference between the two groups before and after the comparison of the two groups of carotid artery ultrasound. The observation group had significant effect on improving the plaque of patients, there was significant difference between the two groups (P 0.01). The rate of stroke recurrence and progressive cerebral infarction in the observation group was lower than that in the control group. The difference is statistically significant. Conclusion: Tiaozhi and Xue granule combined with western medicine routine treatment of atherosclerotic vulnerable plaque is more effective than the treatment of western medicine alone, can improve the clinical symptoms to a greater extent. It is an effective clinical approach for the treatment of ischemic stroke patients with vulnerable plaque.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R277.7

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