本文關鍵詞： 二聯(lián)療法 穴位貼敷 固本培元方 隱匿性腎小球腎炎 血尿 蛋白尿　出處：《遼寧中醫(yī)藥大學》2016年碩士論文　論文類型：學位論文

【摘要】：目的:回顧性分析隱匿性腎小球腎炎患者的蛋白尿和血尿變化,以探討二聯(lián)療法(培本固元方+穴位貼敷)的臨床療效。方法:通過電子病歷系統(tǒng),收集符合納入標準的患者,通過分組標準以及時間順序在觀察組以及對照組各納入60例患者,共120例。120例患者均予基礎內科治療以及培本固元方治療,觀察組在這個方案基礎上增加穴位貼敷治療,120例患者均治療2周,分析治療前后患者的中醫(yī)癥候積分尿沉渣RBC計數(shù)尿蛋白等相關指標的變化。通過回顧性分析治療前后肝功能腎功能血常規(guī)尿常規(guī)便常規(guī)心電圖等指標的變化,以評價二聯(lián)療法的安全性。結果:1.干預治療后,觀察組疾病療效總有效率75.0%,對照組疾病療效總有效率72.7%,差異無統(tǒng)計學意義(P0.05)。2.干預治療后,二聯(lián)療法中醫(yī)證侯療效總有效率96.7%,對照組中醫(yī)證侯療效總有效率86.7%,差異有顯著統(tǒng)計學意義(P0.01)。3.干預治療后兩組證侯總積分均優(yōu)于治療前,差異有顯著統(tǒng)計學意義(P0.01);兩組間比較差異具有顯著統(tǒng)計學意義(P0.01)。4.干預治療后兩組尿沉渣RBC計數(shù)均較治療前有顯著改善,差異具有顯著統(tǒng)計學意義(P0.01);觀察組尿沉渣RBC計數(shù)較非二聯(lián)療法差別較小,差異無統(tǒng)計學意義(P0.05)。5.干預治療后觀察組尿蛋白定量與治療前比較,差異具有顯著統(tǒng)計學意義(P0.01);非二聯(lián)療法尿蛋白與治療前比較,差異有顯著統(tǒng)計學意義(P0.01);治療后兩組間尿蛋白比較,差異無統(tǒng)計學意義(P0.05)。6.觀察組患者在應用二聯(lián)療法后均未出現(xiàn)明顯不適癥狀,治療前后肝功能腎功能血常規(guī)尿常規(guī)便常規(guī)心電圖比較,差異無統(tǒng)計學意義(P0.05)。結論:二聯(lián)療法能顯著改善患者臨床癥狀和體征,降低尿沉渣RBC計數(shù)尿蛋白水平,具有良好的臨床療效,療法安全可靠。
[Abstract]:Objective: to retrospectively analyze the changes of proteinuria and hematuria in patients with occult glomerulonephritis, and to explore the clinical effect of combined therapy. The patients who met the inclusion criteria were collected, and 60 patients were included in the observation group and the control group respectively by grouping criteria and time order. 120 cases (120 cases) were treated with basic medical treatment and Peibengu Yuan prescription, and 120 patients in observation group were treated for 2 weeks. Analysis of patients before and after treatment of TCM symptom score? Urine sediment RBC count? Changes in urinary protein and other related indicators. By retrospective analysis of liver function before and after treatment? Kidney function? Blood routine? Urine routine? Convention? Changes of electrocardiogram and other indicators to evaluate the safety of combined therapy. Results: 1. After intervention, the total effective rate of disease in the observation group was 75.0 and that in the control group was 72.7%. After the intervention treatment, the total effective rate of TCM syndromes was 96.77.The total effective rate of TCM syndromes in the control group was 86.7%. After intervention treatment, the total score of the two groups was better than that before treatment, and the difference was statistically significant (P 0.01). The difference between the two groups was statistically significant (P 0.01). After the intervention treatment, the RBC count of urinary sediment in the two groups was significantly improved compared with that before treatment. The difference was statistically significant (P 0.01). The RBC count of urine sediment in the observation group was smaller than that in the non-dual therapy group, and the difference was not statistically significant (P0.050.5.After the intervention treatment, the urine protein quantity in the observation group was compared with that before treatment. The difference was statistically significant (P 0.01). There was a significant difference in urine protein between non-diadectic therapy and pre-treatment (P 0.01). There was no significant difference in urine protein between the two groups after treatment. The patients in the observation group had no obvious symptoms after the application of combined therapy and the liver function before and after treatment. Kidney function? Blood routine? Urine routine? Convention? There was no significant difference in electrocardiogram (ECG). Conclusion: dual therapy can significantly improve the clinical symptoms and signs of patients and reduce the RBC count of urinary sediment. Urine protein level, has good clinical effect, the treatment is safe and reliable.
【學位授予單位】：遼寧中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R277.5
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本文編號：1468127