本文關(guān)鍵詞：補(bǔ)虛祛濁通絡(luò)法對(duì)老年2型糖尿病輕度認(rèn)知損害及相關(guān)因素的影響　出處：《長(zhǎng)春中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 輕度認(rèn)知損害 2型糖尿病 胰島素抵抗

【摘要】：目的:本研究以“臟虛絡(luò)痹”理論為指導(dǎo),應(yīng)用“補(bǔ)虛祛濁通絡(luò)方”,對(duì)老年2型糖尿病輕度認(rèn)知損害患者進(jìn)行干預(yù),驗(yàn)證其有效性及安全性,同時(shí)觀察其對(duì)胰島素抵抗相關(guān)指標(biāo)的影響。方法:病例全部來(lái)自吉林省中醫(yī)藥科學(xué)院第一臨床醫(yī)院門診患者72例,隨機(jī)分為治療組36例,對(duì)照組36例。兩組均給予既往存在疾病藥物治療,治療組給予口服補(bǔ)虛祛濁通絡(luò)方,觀察兩組患者治療前后中醫(yī)證候療效、簡(jiǎn)易精神狀態(tài)量表(MMSE)、ADAS-Cog量表延遲詞語(yǔ)回憶(ADAS-COG-DVR)、胰島素敏感指數(shù)(ISI)=-In[空腹血糖(FPG)×空腹胰島素(FINS)]、脂聯(lián)素(APN)、瘦素(LPN)的變化。結(jié)果:兩組臨床總體療效比較,治療組總有效率52.8%,優(yōu)于對(duì)照組的2.8%,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。中醫(yī)證候療效比較,治療組在改善遇事善忘、心悸、不寐、少氣懶言、腰膝酸軟、頭暈耳鳴、夜尿頻多、頭重如裹、頭痛如刺九個(gè)癥狀方面明顯優(yōu)于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組認(rèn)知量表(MMSE、ADAS-COG-DVR)積分治療后比較,治療組優(yōu)于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。觀察患者血清APN、LPN、及ISI水平,治療組治療后血清APN水平升高,血清LPN水平降低,ISI水平提高,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:通過(guò)本研究證實(shí),補(bǔ)虛祛濁通絡(luò)法治療老年2型糖尿病輕度認(rèn)知損害方面療效確切,安全性高,該方可能通過(guò)調(diào)節(jié)人體內(nèi)分泌代謝,改善胰島素抵抗,達(dá)到改善認(rèn)知功能的作用。
[Abstract]:Objective: under the guidance of the theory of "zang-deficiency collateral-arthralgia" and "tonifying deficiency and turbid turbid Tongluo recipe", this study intervened the elderly patients with mild cognitive impairment of type 2 diabetes mellitus to verify its efficacy and safety. Methods: 72 outpatients from the first Clinical Hospital of Jilin Academy of traditional Chinese Medicine were randomly divided into treatment group (n = 36). The control group (36 cases) were treated with drugs for the past existing diseases, while the treatment group were given oral prescription of tonifying deficiency, removing turbid turbidity and dredging the collaterals. The curative effect of TCM syndrome and simple mental state scale (MMSE) were observed before and after treatment in the two groups. ADAS-COG-DVR, insulin sensitivity index (ISI) -In. [The changes of fasting blood glucose (FPG) 脳 fasting insulin (fins), adiponectin (APN), leptin (LPN). Results: compared with the two groups, the total effective rate of the treatment group was 52.8%. Better than the control group of 2.8, the difference is statistically significant P0.05.Compared with the curative effect of TCM syndromes, the treatment group in improving good memory, palpitations, sleepless, less Qi lazy speech, weak waist and knee, dizziness tinnitus. The nocturnal urination frequency, head weight as wrapped, headache such as prick nine symptoms were significantly better than the control group, the difference was statistically significant (P 0.05). The two groups of cognitive scale MMSE. After ADAS-COG-DVR) treatment, the treatment group was better than the control group, the difference was statistically significant (P 0.05). In the treatment group, the level of serum APN increased and the level of serum LPN decreased. The difference was statistically significant (P 0.05). The method of tonifying deficiency and removing turbidity and dredging collaterals is effective and safe in treating mild cognitive impairment of senile type 2 diabetes mellitus. The prescription may improve the cognitive function by regulating endocrine metabolism and improving insulin resistance.
【學(xué)位授予單位】：長(zhǎng)春中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259

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