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  本文關鍵詞：柴胡疏肝散加減對腦梗死后抑郁患者血清細胞因子影響及臨床療效研究　出處：《遼寧中醫(yī)雜志》2017年05期 　論文類型：期刊論文

  更多相關文章： 柴胡疏肝散 腦梗死后抑郁 血清細胞因子 臨床療效

【摘要】：目的:探討柴胡疏肝散加減對腦梗死后抑郁患者血清細胞因子影響及臨床療效。方法:選取本院神經(jīng)內(nèi)科診斷及治療的腦梗死后抑郁患者84例,按隨機數(shù)字表法進行分組,對照組患者42例予以舍曲林治療,研究組患者42例在對照組基礎上予以柴胡疏肝散加減治療,采血檢測血清S100β及BDNF水平、血清細胞因子水平,記錄生存狀況評分,同時對比臨床療效及并發(fā)癥。結果:對照組治療有效率71.43%低于研究組治療有效率90.48%,具有統(tǒng)計學意義(P0.05);與對照組比較,研究組患者治療后血清S100β水平降低,血清BDNF水平升高,治療后血清CRP、IL-6及TNF-α水平降低,治療后HAMD、NIHSS及ADL評分降低,MMSE評分升高,具有統(tǒng)計學意義(P0.05);兩組患者不良反應多為輕中度,患者能夠耐受,對癥處理后緩解。結論:柴胡疏肝散加減對腦梗死后抑郁患者療效確切,降低血清細胞因子,值得推廣。
[Abstract]:Objective: To investigate the effect of Chaihu Shugan powder on serum cytokine and its clinical effect in patients with depression after cerebral infarction. Methods: 84 patients with depression were selected for diagnosis and treatment of the neurology department of our hospital after cerebral infarction were divided into two groups randomly, 42 patients in the control group were treated with sertraline in the treatment of patients in the study group, 42 cases in the control group on the basis of ChaiHuShuGan powder treatment, blood serum S100 level, serum BDNF and beta cell cytokines and recorded the survival status score, and the clinical effect and complications of contrast. Results: in the control group the effective rate was 71.43% lower than the effective rate of treatment group 90.48%, with statistical significance (P0.05); compared with the control group, serum S100 of patients in the study group after treatment decreased serum level of BDNF after treatment, serum CRP, IL-6 and TNF- levels decreased, HAMD, NIHSS and ADL were lower after treatment, the MMSE score increased, with statistical significance (P0.05); the adverse reactions of the two groups were mild to moderate, the patients can tolerate the treatment. Conclusion: the addition and subtraction of Chaihu Shugan powder is effective for the patients with depression after cerebral infarction, and it is worth promoting to reduce the serum cytokines.
【作者單位】： 天津中醫(yī)藥大學第二附屬醫(yī)院心理二診室;秦皇島市人民醫(yī)院神經(jīng)內(nèi)科;
【分類號】：R277.7
【正文快照】： 腦梗死后抑郁是腦梗死后常見的并發(fā)癥,其發(fā)生率達到20%~60%[1-2]。由于多數(shù)腦梗死患者存在神經(jīng)功能障礙,語言交流不利,極易引起漏診和誤診現(xiàn)象,對患者的康復及生存質量產(chǎn)生影響,并且增加患者死亡率[3]。因此采取及時、有效的治療措施既能夠提高梗死抑郁患者的預后及生活質量,

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