【摘要】：目的觀察錯(cuò)配修復(fù)基因(MMR)在非轉(zhuǎn)移性結(jié)直腸組織中的表達(dá)狀態(tài)并探討其意義。方法選取141例接受手術(shù)治療的非轉(zhuǎn)移性結(jié)直腸癌患者,均未接受術(shù)前放療或化療。術(shù)后病理標(biāo)本進(jìn)行常規(guī)病理檢測(cè)及免疫組化法檢測(cè)4種MMR蛋白(MLH1、MSH2、MSH6、PMS2)表達(dá)。四種蛋白中一種及以上不表達(dá),即判定為MMR表達(dá)缺失(d MMR),對(duì)比MMR正常和d MMR結(jié)直腸癌患者的臨床病理特征。結(jié)果非轉(zhuǎn)移性結(jié)直腸癌患者的MLH1、MSH2、MSH6、PMS2表達(dá)缺失率分別為15.6%(22/141)、2.8%(4/141)、7.1%(10/141)、15.6%(22/141),d MMR率為25.5%(36/141)。MMR表達(dá)與非轉(zhuǎn)移性結(jié)直腸癌患者年齡、部位、腫瘤大小及病理類型等有關(guān)(P均0.05),d MMR更多發(fā)生于60歲以下、近端部位、黏液類型癌及較大的腫瘤(P均0.05)。結(jié)論非轉(zhuǎn)移性結(jié)直腸癌患者癌組織中MMR表達(dá)存在缺失,MMR狀態(tài)的評(píng)估有助于判斷患者預(yù)后和指導(dǎo)治療。
[Abstract]:Objective to observe the expression of mismatch repair gene (MMR) in non-metastatic colorectal tissues and to explore its significance. Methods 141 patients with non-metastatic colorectal cancer who underwent surgical treatment were not treated with preoperative radiotherapy or chemotherapy. The expression of four kinds of MMR proteins (MLH1,MSH2,MSH6,PMS2) was detected by routine pathological examination and immunohistochemistry in postoperative pathological specimens. One or more of the four proteins were not expressed, that is to say, the loss of MMR expression (d MMR), was compared with the clinicopathological features of MMR normal and d MMR colorectal cancer patients. Results the deletion rate of MLH1,MSH2,MSH6,PMS2 expression in patients with non-metastasis colorectal cancer was 15.6% (22 鈮，

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