【摘要】：目的:探討肝癌肝臟切除手術(shù)后肝臟功能恢復(fù)影響因素,并建立風(fēng)險預(yù)測模型。方法:回顧性分析2015年2月—2016年9月間行半肝切除手術(shù)的50例肝癌患者術(shù)的相關(guān)臨床資料,通過單變量與多變量分析對篩選出可能影響肝癌患者術(shù)后肝臟功能恢復(fù)的因素,用所得各因素及其統(tǒng)計(jì)值建立風(fēng)險預(yù)測模型。結(jié)果:患者手術(shù)前吲哚菁綠15分鐘滯留率(ICGR15)、清除指數(shù)(HH15)、殘余肝臟體積/標(biāo)準(zhǔn)肝臟體積(RLV/SLV)均為半肝切除手術(shù)后肝臟功能恢復(fù)的獨(dú)立危險因素(P=0.002、P0.001、P=0.007);所得到的風(fēng)險預(yù)測模型為:風(fēng)險系數(shù)(R)=31.871×(RLV/SLV)-1.689×(ICG R15)-19.663×HH15;R的臨界值為0.90時,其預(yù)測術(shù)后出現(xiàn)肝功能不全的ROC曲線下面積為0.96,敏感度和特異度為97.5%和90%。結(jié)論:較低的RLV/SLV以及較高的ICGl5R和HH15是肝癌患者行肝臟切除術(shù)后肝功能不全的危險因素,所建立的預(yù)測模型有一定的風(fēng)險評估價值。
[Abstract]:Objective: to investigate the influencing factors of liver function recovery after hepatectomy for hepatocellular carcinoma (HCC) and to establish a risk prediction model. Methods: the clinical data of 50 patients with liver cancer who underwent semi-hepatectomy from February 2015 to September 2016 were analyzed retrospectively. the factors that might affect the recovery of liver function in patients with liver cancer were screened out by univariable and multivariate analysis. The risk prediction model is established by using the obtained factors and their statistical values. Results: the 15-minute retention rate (ICGR15), clearance index (HH15) and residual liver volume / standard liver volume (RLV/SLV) were independent risk factors for liver function recovery after semi-hepatectomy (P 鈮，

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