【摘要】：目的對宮頸癌患者生殖道細菌感染及人乳頭瘤病毒(HPV)感染情況進行研究,探討宮頸癌和生殖道細菌感染及人乳頭瘤病毒感染的關系。方法選擇2012年1月-2014年12月湖州市中心醫(yī)院婦產科宮頸癌患者108例作為宮頸癌組,慢性宮頸炎患者108例作為宮頸炎組,對兩組患者陰道分泌物進行細菌培養(yǎng),并檢測HPV感染情況。結果 108例宮頸癌患者檢出細菌60例,檢出率為55.6%,108例慢性宮頸炎患者中檢出細菌53例,檢出率為49.1%;宮頸癌組和宮頸炎組患者生殖道細菌培養(yǎng)陽性率比較差異無統(tǒng)計學意義;宮頸癌組和宮頸炎組患者生殖道革蘭陽性菌和革蘭陰性菌分布比較差異無統(tǒng)計學意義;108例宮頸癌患者中生殖道HPV感染65例,感染率60.2%,108例慢性宮頸炎患者生殖道HPV感染44例,感染率40.7%;宮頸癌組患者生殖道HPV陽性率高于宮頸炎組(P0.05);宮頸癌患者中HPV陽性組和HPV陰性組生殖道細菌培養(yǎng)結果比較差異無統(tǒng)計學意義;宮頸癌組和宮頸炎組HPV陽性患者中生殖道細菌培養(yǎng)結果比較差異無統(tǒng)計學意義。結論生殖道HPV感染為宮頸癌的高危因素,生殖道細菌感染可能和宮頸癌的發(fā)生無關。
[Abstract]:Aim to investigate the relationship between bacterial infection of cervical cancer and reproductive tract and human papillomavirus (HPV) infection by studying the bacterial infection of reproductive tract and (HPV) infection of human papillomavirus (HPV) in cervical cancer patients. Methods 108 cervical cancer patients in Huzhou Central Hospital from January 2012 to December 2014 were selected as cervical cancer group and 108 chronic cervicitis patients as cervicitis group. HPV infection was detected. Results bacteria were detected in 60 cases (55.6%) of 108 cases of cervical cancer and 53 cases (49.1%) of 108 cases of chronic cervicitis. There was no significant difference between cervical cancer group and cervicitis group in the positive rate of germ culture, but there was no significant difference between cervical cancer group and cervicitis group in the distribution of Gram-positive bacteria and Gram-negative bacteria in the reproductive tract of cervical cancer group and cervicitis group. The infection rate of HPV was 60.2% in 65 cases of cervical cancer, and 40.7% in 44 cases of chronic cervicitis, the positive rate of HPV in cervical cancer group was higher than that in cervicitis group (P0.05), and the positive rate of HPV in cervical cancer group was higher than that in cervicitis group (P0.05). There was no significant difference between HPV-positive group and HPV-negative group in bacterial culture of genital tract between cervical cancer group and cervicitis group, but there was no significant difference between cervical cancer group and cervicitis group in HPV-positive group. Conclusion HPV infection in reproductive tract is a high risk factor of cervical cancer, and bacterial infection in reproductive tract may not be related to the occurrence of cervical cancer.
【作者單位】： 湖州市中心醫(yī)院婦產科;湖州市婦幼保健院產前診斷中心;
【基金】：浙江省醫(yī)藥衛(wèi)生一般研究計劃項目(2014KYA208)
【分類號】：R737.33

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