【摘要】：目的探討經(jīng)導管肝動脈化療栓塞(TACE)術前血清天冬氨酸轉(zhuǎn)氨酶(AST)和中性粒細胞比值(ANRI)對肝細胞肝癌患者預后的評估價值。方法收集2008年1月至2011年6月期間107例肝細胞肝癌患者的臨床資料,研究對象均成功施行TACE,以5年總生存率繪制ROC曲線確定截斷值,對術前患者的ANRI、AST與淋巴細胞比值(ALRI)、AST與血小板計數(shù)比值(APRI)、中性粒細胞與淋巴細胞比值(NLR)、血小板計數(shù)與淋巴細胞比值(PLR)及其他臨床病理參數(shù)進行單因素、多因素Logisitc回歸分析及Kaplan-Meier生存分析,以確定上述因素對無病生存期(DFS)和生存期(OS)的預測價值。結(jié)果ANRI與HBs Ag、AST、肝硬化的存在、腫瘤大小、門靜脈癌栓及腫瘤的復發(fā)具有相關性(P0.05)。通過單因素分析顯示,ANRI、ALRI、APRI、NLR、PLR與接受TACE治療肝癌患者的DFS和OS具有顯著相關性(P0.05)。多因素Logisitc回歸分析顯示,ANRI被證明是該類患者DFS和OS的獨立影響因素(P0.05)。Kaplan-Meier生存分析表明,術前ANRI7.8的患者行TACE治療后預后較差。結(jié)論 TACE術前ANRI水平是肝細胞肝癌患者預后獨立的預測因素,ANRI水平較高往往提示該類患者行TACE治療的預后較差。
[Abstract]:Objective to evaluate the prognostic value of serum aspartate aminotransferase (AST) and neutrophil ratio (ANRI) in patients with hepatocellular carcinoma (HCC) before transcatheter hepatic artery chemoembolization (TACE). Methods the clinical data of 107 patients with hepatocellular carcinoma (HCC) from January 2008 to June 2011 were collected. TACE, was successfully performed to draw the ROC curve to determine the truncation value with 5-year overall survival rate. The ratio of ANRI,AST / lymphocyte to (ALRI), AST / platelet count ratio of (APRI), neutrophil to lymphocyte ratio (NLR), platelet count to lymphocyte ratio (PLR) and other clinicopathological parameters were studied. Multivariate Logisitc regression analysis and Kaplan-Meier survival analysis were used to determine the predictive value of these factors for disease-free survival (DFS) and survival (OS). Results ANRI was correlated with the presence of HBs Ag,AST, cirrhosis, tumor size, portal vein tumor thrombus and tumor recurrence (P0.05). Univariate analysis showed that ANRI,ALRI,APRI,NLR,PLR was significantly correlated with DFS and OS in patients with liver cancer treated with TACE (P0.05). Multivariate Logisitc regression analysis showed that ANRI was proved to be an independent factor of DFS and OS in this group of patients (P0.05). Kaplan-Meier survival analysis showed that the prognosis of patients with preoperative ANRI7.8 after TACE treatment was poor. Conclusion the level of ANRI before TACE is an independent predictor of the prognosis of HCC patients, and the high level of ANRI often indicates that the prognosis of the patients treated with TACE is poor.
【作者單位】： 貴州醫(yī)科大學附屬醫(yī)院介入科;
【分類號】：R735.7
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本文編號：2289520