【摘要】：目的評估晚期食管癌患者一線化療前基線營養(yǎng)狀態(tài)對化療療效、不良反應和患者生存期的影響。方法回顧性收集一線化療的56例不可手術的局部進展期或轉(zhuǎn)移性食管癌患者的臨床資料及化療前營養(yǎng)狀況資料,并分析其與患者化療療效、不良反應及生存期的相關性。結果血紅蛋白(hemoglobin,Hb)的水平與患者3級以上血液學毒性明顯相關,其中Hb130 g/L者較90~130 g/L者3級以上血液學毒性的發(fā)生率顯著降低(34.2%vs.72.2%,P=0.008),但兩者在3級以上非血液學毒性上并無差別(P0.05);多因素分析中,有無遠處轉(zhuǎn)移和體重下降程度是患者的獨立預后因素,有遠處轉(zhuǎn)移(P=0.005)、體重下降≥5%(P=0.002)與患者預后差相關。結論對于不可手術的局部進展期或轉(zhuǎn)移性食管癌患者,化療前基線營養(yǎng)狀態(tài)在預測化療不良反應及評估患者預后方面有一定作用。
[Abstract]:Objective to evaluate the effects of baseline nutritional status on chemotherapy efficacy, adverse reactions and survival in patients with advanced esophageal cancer. Methods the clinical data and nutritional status of 56 patients with non-operative local advanced or metastatic esophageal carcinoma were collected retrospectively. The correlation between the clinical data and the curative effect, adverse reaction and survival time of the patients was analyzed. Results the level of hemoglobin (hemoglobin,Hb) was significantly correlated with the hematological toxicity of patients above grade 3. The incidence of hematological toxicity above grade 3 in Hb130 g / L group was significantly lower than that in 90 g / L group (34.2vs.72.2% P0. 008), but there was no difference in non-hematological toxicity between the two groups (P0.05). Distant metastasis and weight loss were independent prognostic factors. Distant metastasis (P0. 005) and weight loss 鈮，

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