本文選題：芪絡(luò)湯 + 大腸癌�。� 參考：《福建中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的：觀察芪絡(luò)湯對大腸癌手術(shù)化療后脾虛濕熱證患者生活質(zhì)量等的影響及其安全性評估。方法：本研究采用隨機平行對照試驗法,將64例符合納入標(biāo)準(zhǔn)的大腸癌手術(shù)化療后脾虛濕熱證的患者隨機分為治療組32例和對照組32例。治療組予口服芪絡(luò)湯,對照組予注射胸腺五肽。3個月后,比較兩組患者的生活質(zhì)量、體重、中醫(yī)證侯積分、細胞免疫功能、腫瘤標(biāo)志物等方面作為療效評價,記錄不良反應(yīng),并觀察血常規(guī)和心肝腎功結(jié)果作為安全性評價,并對數(shù)據(jù)進行統(tǒng)計分析。結(jié)果：(1)研究總納入64例,脫失2例,實際完成62例,總脫失率3.1%。(2)生活質(zhì)量：治療結(jié)束后,治療組生活質(zhì)量提高16例,穩(wěn)定15例,降低0例,對照組生活質(zhì)量提高7例,穩(wěn)定19例,降低5例,兩組比較差異有統(tǒng)計學(xué)意義(P＜0.05)。(3)體重變化：治療結(jié)束后,治療組體重升高11例,穩(wěn)定17例,降低3例,對照組體重升高5例,穩(wěn)定18例,降低8例,兩組差異有統(tǒng)計學(xué)意義(P＜0.05)。(4)中醫(yī)證侯療效：治療后,治療組的中醫(yī)證候積分較對照組顯著降低(P≥0.05),各單項中醫(yī)證候中,治療組神疲乏力、氣短懶言、口干口苦、肢體困重、食欲不振、便溏或結(jié)等證候的改善明顯優(yōu)于對照組(P＜0.05)。(5)血清腫瘤標(biāo)志物比較：兩組患者血清CEA、CA199水平治療后均無明顯變化(P＞.05)。(6)免疫指標(biāo)：治療組和對照組治療后CD3+、CD4+、CD4+/CD8+、NK細胞等免疫指標(biāo)較治療前均明顯升高(P＜O.05)；兩組CD8+均顯著下降(P＜0.05)；而治療后兩組各項免疫指標(biāo)的變化比較無顯著差異(P＜0.05)。(7)安全性評估：治療組新發(fā)輕度惡心1例,未作處理自行緩解,兩組對血常規(guī)和心肝腎功能均未造成不良影響。結(jié)論：芪絡(luò)湯能明顯改善大腸癌手術(shù)化療后脾虛濕熱證患者生活質(zhì)量和中醫(yī)證侯積分;芪絡(luò)湯對患者的體重下降有保護作用；芪絡(luò)湯能明顯提高患者細胞免疫水平；臨床應(yīng)用安全有效。
[Abstract]:Objective: to observe the effect of Qiluo decoction on quality of life of patients with spleen deficiency dampness heat syndrome after operation chemotherapy for colorectal cancer. Methods: in this study, 64 patients with spleen deficiency dampness and heat syndrome were randomly divided into treatment group (n = 32) and control group (n = 32). The treatment group was treated with Qiluo decoction and the control group was injected with thymic pentapeptide. After 3 months, the quality of life, weight, TCM syndromes score, cellular immune function, tumor markers and other aspects of the patients in the two groups were compared as therapeutic evaluation, and adverse reactions were recorded. The blood routine and the results of heart, liver and kidney were observed as safety evaluation, and the data were statistically analyzed. Results in the study, 64 cases were included, 2 cases were lost, 62 cases were actually completed, and the total loss rate was 3.1%. 2) the quality of life in the treatment group was improved in 16 cases, stable in 15 cases, decreased in 0 cases after treatment. In the control group, the quality of life was improved in 7 cases. There were 19 stable cases, 5 cases decreased. The difference between the two groups was statistically significant (P < 0.05). The weight of the treatment group increased in 11 cases, stabilized in 17 cases, decreased in 3 cases, and increased in 5 cases, stable in 18 cases and decreased in 8 cases in the control group. The difference between the two groups was statistically significant (P < 0.05).) the curative effect of TCM syndrome: after treatment, the score of TCM syndrome in the treatment group was significantly lower than that in the control group (P 鈮，

本文編號：2007010