本文選題：易普利姆瑪　切入點：晚期黑色素瘤　出處：《重慶醫(yī)科大學》2017年碩士論文　論文類型：學位論文

【摘要】：目的:對易普利姆瑪治療黑色素瘤患者的有效性及安全性進行meta分析。方法:計算機檢索Pub Med,the Cochrane Library,Embase,中國知網(wǎng)、萬方和維普數(shù)據(jù)庫。依據(jù)設定的納入及排除標準選取論文,并且提取信息、評估研究質量后,運用Rev Man 5.3軟件對符合要求的研究進行meta分析。結果:經(jīng)篩選后有4篇論文滿足要求,納入的病例總數(shù)是2622例。Meta分析結果顯示:與對照組相比,易普利姆瑪組1年無進展生存率(RR=0.94,95%CI:0.91~0.98,P=0.001)、1年總生存率(RR=0.79,95%CI:0.72~0.87,P0.00001)較高,具有統(tǒng)計學差異。2年無進展生存率(RR=0.99,95%CI:0.97~1.01,P=0.45)及3年總生存率(RR=0.93,95%CI:0.84~1.03,P=0.17)均無統(tǒng)計學差異。易普利姆瑪組患者皮疹(RR=2.43,95%CI:1.64~3.61,P0.00001)、瘙癢(RR=2.35,95%CI:1.67~3.29,P0.00001)、腹瀉(RR=1.82,95%CI:1.47~2.25,P0.00001)、結腸炎(RR=11.21,95%CI:6.20~20.30,P0.00001)、丙氨酸氨基轉移酶增高(RR=3.57,95%CI:1.92~6.62,P0.0001)、天門冬氨酸氨基轉移酶增高(RR=3.81,95%CI:2.85~5.09,P0.00001)的發(fā)生率均較高。結論:易普利姆瑪可提高患者1年無進展生存率、1年總生存率,但在2年無進展生存率及3年總生存率方面未顯示出優(yōu)勢,且易普利姆瑪增加了患者出現(xiàn)皮疹、瘙癢、腹瀉、結腸炎和轉氨酶升高的風險。
[Abstract]:Objective: to analyze the efficacy and safety of Eprimma in the treatment of melanoma by meta. Methods: the Pub Medsite, the Cochrane Library Embase, the Wan-Fang and Weip databases were searched by computer, and the papers were selected according to the established inclusion and exclusion criteria. After extracting the information and evaluating the quality of the research, meta analysis was carried out by using Rev Man 5.3 software. Results: after screening, 4 papers met the requirements. The total number of cases included was 2622. Meta-analysis showed that compared with the control group, the 1-year progression-free survival rate of the Eprimma group was higher than that of the control group, and the 1 year overall survival rate was higher than that of the control group. There was no statistical difference in the 2-year progression-free survival rate (RRN 0.99 ~ 95CI0.97 P0.45) and the 3-year overall survival rate (RRN 0.9395CI0.84N 1.03P0.17). There was no statistical difference in the 2-year progressive survival rate (RR2.4395CI1.643.61C), RRR2.3595CI1.673.29P0.00001N) and the overall 3-year survival rate (RRR1.0395CI0.841.0395CI0.80.8395CI0.8395CI0.8395CI0.8395CI0.8395CI0.8395CI0.8395CI0.8395CI0.8395CI0.8395C0.17), RR2.395CI1.643.61C (P 0.00001), RRR1.82CI1.82CI1.82CI1.25P0.00001a, RR11.21a, CI6.2020.30P0011a, the elevation of the alanine aminotransferase R53.951a in R53.959CI1.000. The incidence of RRX 3.81C 95% CI: 2.85% 5.09% P0.00001) was higher. Conclusion: the 1-year progression-free survival rate and 1-year overall survival rate can be improved by Iprimma. But there was no advantage in 2-year progression-free survival and 3-year overall survival, and Eprimma increased the risk of rash, pruritus, diarrhea, colitis and elevated transaminase.
【學位授予單位】：重慶醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R739.5

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