本文關(guān)鍵詞：腫瘤干細(xì)胞耐藥機制研究進展，由筆耕文化傳播整理發(fā)布。

國際婦產(chǎn)科學(xué)雜志 2011年 2月第 38卷第 1期 J Int Obstet Gynecol袁F(xiàn)ebruary 2011袁Vol. 38袁No.1 窯60窯 ?綜 述? 卵巢腫瘤干細(xì)胞耐藥機制研究進展 吳開元綜述 史惠蓉審校 揖摘 要銥 卵巢癌治療中的主要問題是高復(fù)發(fā)率和產(chǎn)生耐藥性遙腫瘤干細(xì)胞具有無限增殖的能力袁對藥 物的耐受性增加袁提示腫瘤干細(xì)胞與化療耐藥的關(guān)系密切遙從耐藥卵巢癌細(xì)胞中可分選出具有特定表面標(biāo)志 的腫瘤干細(xì)胞袁其為腫瘤形成提供可自我更新并在傳代中保持腫瘤特性不變袁是卵巢癌耐藥性產(chǎn)生和復(fù)發(fā)的 根本原因遙利用卵巢癌干細(xì)胞表面標(biāo)志分子的特異性袁使化療藥物選擇性地與卵巢癌干細(xì)胞結(jié)合袁徹底消除 腫瘤復(fù)發(fā)和耐藥根源袁可為卵巢癌患者提供更有效的化療方案遙 揖關(guān)鍵詞銥 卵巢腫瘤曰 腫瘤干細(xì)胞曰抗藥性袁腫瘤曰 生物學(xué)標(biāo)記曰免疫曰多藥耐藥相關(guān)蛋白質(zhì)類 Research Progress in Determing the Relationship Between Ovarian Cancer Stem Cells and Chemoresistance WU Kai -yuan, SHI Hui-rong. Department of Gynecology and Obstetrics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China 揖Abstract銥 A major problem in the treatment of ovarian cancer is the high percentage of recurrence and chemoresistance. Cancer stem cells 淵CSCs冤 can proliferate indefinitely, be proved enhancing chemoresistance and indicatea close relationship with chemoresistance. CSCs with definite cell surface maker can be separated from chemoresistant ovarian cancer cells, they can providea reservoir of cells that can self -renew, maintain the tumor which make up the bulk of the tumor and may be the primary source of recurrence and chemoresistance. According to the special cell-surface marker and making chemotherapeutics selectively binding with ovarian cancer stem cells, can eliminate cancer recurrence and chemoresistance thoroughly and provide more effective che

  本文關(guān)鍵詞：腫瘤干細(xì)胞耐藥機制研究進展，由筆耕文化傳播整理發(fā)布。