本文關(guān)鍵詞： 模擬失重 紫檀芪 藥物排泄 LC-MS 大鼠　出處：《航天醫(yī)學(xué)與醫(yī)學(xué)工程》2015年02期 　論文類型：期刊論文

【摘要】：目的研究紫檀芪(pterostilbene,PTS)在正常及模擬失重大鼠尿液及糞便中的排泄規(guī)律。方法正常對(duì)照大鼠和尾吊21 d模擬失重后大鼠,灌胃給予33 mg/kg PTS,采用LC-MS法測(cè)定各時(shí)間段尿糞樣本中PTS含量,獲取PTS在尿糞中排泄百分比及排泄量數(shù)據(jù)。結(jié)果正常對(duì)照大鼠給藥48 h內(nèi),PTS在尿糞中排泄速度較慢,給藥72 h后,PTS在尿糞中的累計(jì)排泄量分別為(2.16±0.26)μg、(2.11±0.26)μg,占給藥劑量的(0.25±0.04)‰、(0.24±0.03)‰。與對(duì)照組相比,PTS在模擬失重大鼠尿糞中排泄量顯著增高。給藥72 h后,PTS在尿糞中的累計(jì)排泄量分別為(4.39±0.83)μg、(3.83±0.69)μg,占給藥劑量的(0.63±0.13)‰、(0.56±0.09)‰。結(jié)論 PTS在正常和模擬失重21 d大鼠體內(nèi),尿液及糞便排泄量存在顯著差異,模擬失重狀態(tài)顯著影響PTS在大鼠尿液及糞便的排泄過(guò)程。
[Abstract]:Objective to study the excretion rule of pterostilbene in urine and feces of normal and simulated weightlessness rats. Methods normal control rats and tail suspended rats after 21 days of simulated weightlessness were given 33 mg/kg PTSs intragastrically. The content of PTS in fecal samples was determined by LC-MS method. The data of excretion percentage and excretion amount of PTS in urine feces were obtained. Results the excretion rate of PTS in urine feces was slower in normal control rats within 48 hours. The accumulative excretion of PTS in urine feces was 2.16 鹵0.26 渭 g after 72 hours of administration, accounting for 0.25 鹵0.04 鈥，

本文編號(hào)：1544459