【摘要】：目的探討急性型胼胝體變性(MBD)的臨床表現(xiàn)和影像學(xué)特點(diǎn)。方法對(duì)該院診治的3例急性型MBD患者進(jìn)行回顧性分析,包括臨床表現(xiàn)、實(shí)驗(yàn)室檢查、影像學(xué)檢查(頭顱CT、MRI)和隨訪結(jié)果。結(jié)果 3例患者均急性起病,主要表現(xiàn)為意識(shí)障礙、精神異常、癲癇發(fā)作、譫妄性震顫、高熱等;CT與MRI可見(jiàn)胼胝體膝部和壓部病灶,CT示病灶為低密度,MRI表現(xiàn)為T1WI等或低信號(hào),T2WI高信號(hào),液體衰減反轉(zhuǎn)恢復(fù)序列高信號(hào),彌散加權(quán)成像(DWI)高信號(hào),ADC等或低信號(hào);3例均伴發(fā)雙側(cè)大腦半球白質(zhì)對(duì)稱性病灶,1例出現(xiàn)腦橋臂對(duì)稱性病灶,1例胼胝體膝部及體部出現(xiàn)類似"三明治"樣改變。結(jié)論急性型MBD臨床表現(xiàn)多樣,無(wú)特異性,但具有特征性影像學(xué)表現(xiàn)。
[Abstract]:Objective to investigate the clinical and imaging features of acute corpus callosum degeneration (MBD). Methods three patients with acute MBD were retrospectively analyzed, including clinical manifestation, laboratory examination, imaging examination and follow-up results. Results all of the 3 patients had acute onset, mainly manifested as disturbance of consciousness, abnormal spirit, seizure, delirium tremor. High fever isochromatic CT and MRI showed that the lesions of the corpus callosum in knee and pressure showed low density MRI with high signal intensity on T1WI isointense or hypointensity T 2WI and high signal intensity on fluid attenuated inversion recovery sequence. Diffusion weighted imaging (DWI) with high signal intensity or low signal intensity in 3 cases were accompanied by bilateral cerebral hemisphere white matter symmetry lesions. One case had a symmetrical lesion of the pons arm and the other case had similar "sandwich" like changes in the genu and body of corpus callosum. Conclusion the clinical manifestations of acute MBD are diverse and non-specific, but have characteristic imaging findings.
【作者單位】： 重慶市涪陵中心醫(yī)院神經(jīng)內(nèi)科;中南大學(xué)湘雅醫(yī)院神經(jīng)內(nèi)科;
【分類號(hào)】：R744.5;R445.2;R816.1

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