本文選題：蒙特卡羅方法 + 粒子輸運�。� 參考：《強激光與粒子束》2017年12期

【摘要】：提出一種基于磁場調制的質子放射治療新方法,探索腫瘤劑量、正常器官劑量與磁場調制方法之間的關聯(lián)機制,研究磁場調制質子放療在器官環(huán)繞型腫瘤(腫瘤被正常器官環(huán)繞或包圍)治療中的應用。基于蒙特卡羅粒子輸運程序Geant4,分別建立了理想器官環(huán)繞結構(由若干平行六面體結構組成)和含胰腺腫瘤人體腹部解剖結構兩種幾何構型。分別對兩種幾何構型內部施加磁場,通過改變磁場強度和方向,調制質子束布拉格峰幾何位置,利用質子徑跡的磁致偏轉效應使質子束繞開正常器官對腫瘤進行照射。對于理想器官環(huán)繞型構型,磁場調制質子放療可在保證95%劑量覆蓋腫瘤情況下將受質子照射正常器官體積控制在接近于零的極低水平。對于胰腺腫瘤解剖構型,磁場調制方法可使質子束在調制磁場作用下,繞過脊髓和腎臟照射腫瘤,并使腫瘤被95%劑量較好地覆蓋。通過磁場調制,可對質子束布拉格峰幾何位置和質子徑跡彎曲程度進行調制,繞過正常器官對腫瘤進行照射,從而最大限度地減少正常器官的受照體積和劑量。
[Abstract]:A new method of proton radiation therapy based on magnetic field modulation is proposed to explore the mechanism of correlation between tumor dose, normal organ dose and magnetic field modulation. To study the application of magnetic field modulated proton radiotherapy in the treatment of organ surrounding tumor (tumor surrounded or surrounded by normal organ). Based on Monte Carlo particle transport program Geant4, two geometries, ideal organ encircling structure (composed of several parallel hexahedron structures) and human abdominal anatomic structure with pancreatic tumor, were established. By changing the intensity and direction of the magnetic field and modulating the geometric position of the proton beam Bragg peak, the proton beam can be irradiated by the magnetic deflection effect of the proton track around the normal organs. For ideal organ encircling configuration, magnetic field modulated proton radiotherapy can control the normal organ volume of protonic irradiation to close to zero when 95% dose is guaranteed to cover the tumor. For the anatomical configuration of pancreatic tumors, the magnetic field modulation method can make the proton beam bypass the spinal cord and kidney to irradiate the tumor under the action of modulated magnetic field, and make the tumor better covered by 95% dose. The geometric position of the Bragg peak of the proton beam and the degree of curve of the proton track can be modulated by the magnetic field modulation, and the tumor can be irradiated by bypassing the normal organ, thus minimizing the radiation volume and dose of the normal organ.
【作者單位】： 南京航空航天大學核科學與工程系;哈爾濱醫(yī)科大學附屬腫瘤醫(yī)院放射物理科;
【基金】：國家自然科學基金項目(11475087)
【分類號】：R730.55
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本文編號：1808357