【摘要】：目的評價乳桿菌屬及雙歧桿菌屬對成年人血脂水平的影響。方法計算機檢索Pubmed、EMbase、Web of Science、Cochrane Library、中國學術期刊網(wǎng)絡出版總庫、萬方醫(yī)學數(shù)據(jù)庫、維普中文科技期刊全文數(shù)據(jù)庫。檢索時間年限為建庫至2016年1月。納入標準為單純使用乳桿菌屬和(或)雙歧桿菌屬調(diào)節(jié)血脂的臨床隨機對照試驗,研究對象年齡≥18歲,文獻Jadad評分3分。提取資料后采用Revman 5.3軟件進行Meta分析。結果共納入11篇文獻,合計871例研究對象。Meta分析結果顯示,與對照組比較,應用乳桿菌屬、雙歧桿菌屬可以顯著降低血總膽固醇水平(WMD=-0.45 mmol/L,95%CI:-0.63~-0.27 mmol/L,P0.001)和低密度脂蛋白膽固醇水平(WMD=-0.42 mmol/L,95%CI:-0.46~-0.38 mmol/L,P0.001),差異有統(tǒng)計學意義。結論乳桿菌屬及雙歧桿菌屬對成年人血膽固醇代謝有一定積極影響。
[Abstract]:Objective to evaluate the effect of Lactobacillus and Bifidobacterium on serum lipids in adults. Methods Pubmed,EMbase,Web of Science,Cochrane Library, Chinese academic journals were searched by computer, including the General Library of Chinese academic Journals, the Wanfang Medical Database and the full text Database of Weipu Chinese Science and Technology Journals. The retrieval time period is to build the database until January 2016. The inclusion criteria were randomized controlled trials using only Lactobacillus and / or Bifidobacterium to regulate blood lipids. The subjects were aged more than 18 years with a Jadad score of 3 in the literature. After extracting the data, Meta analysis was carried out with Revman 5.3 software. Results A total of 871 subjects were included in 11 literatures. Meta analysis showed that the application of Lactobacillus and Bifidobacterium could significantly reduce the serum total cholesterol level (WMD=-0.45 mmol/L,) compared with the control group. 95%CI:-0.63~-0.27 mmol/L,P0.001 and low density lipoprotein cholesterol (WMD=-0.42 mmol/L,95%CI:-0.46~-0.38 mmol/L,P0.001) levels were significantly different. Conclusion Lactobacillus and Bifidobacterium have positive effects on blood cholesterol metabolism in adults.
【作者單位】： 四川大學華西公共衛(wèi)生學院(華西第四醫(yī)院);四川大學華西醫(yī)院臨床營養(yǎng)科;
【分類號】：R151.41

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