本文選題：食用竹炭粉　切入點：大鼠　出處：《衛(wèi)生研究》2016年04期

【摘要】：目的探討食用竹炭粉(bamboo charcoal powder,BCP)對高脂模型大鼠的降脂作用及其機制。方法 4周齡SPF級雄性SD大鼠,隨機分成5組:空白對照組,高脂模型對照組和BCP低、中、高劑量(2.81、5.62、11.24 g/kg)干預組。各組每日灌胃相應劑量的竹炭粉或蒸餾水,連續(xù)90 d。股動脈取血測定肝腎功能等生化指標;取肝、腎及雙側腎臟及附睪周圍的脂肪稱重;取左側肝葉做組織病理學檢查;制備肝勻漿,檢測總膽固醇(TC)、甘油三酯(TG)、總抗氧化能力(T-AOC)、過氧化氫酶(CAT)、超氧化物歧化酶(SOD)和丙二醛(MDA)含量。結果從第4周起高脂模型對照組體重顯著高于同期空白對照組,同時高脂模型對照組脂/體比、血清谷丙轉氨酶(ALT)、TG和極低密度脂蛋白(VLDL)均高于空白對照組;高脂模型對照組肝臟可觀察到明顯的脂肪變性,肝臟中MDA、TC和TG含量均高于空白對照組,表明造模成功。BCP各劑量組與高脂模型對照組比較,體重、肝重及脂/體比均明顯降低,血清ALT、TG和VLDL濃度降低,肝臟脂肪變性程度減輕,同時肝臟中TC和MDA濃度也均降低,T-AOC、SOD和CAT活性升高。結論食用竹炭粉具有減少高脂模型大鼠體內脂肪蓄積、降血脂、減輕肝臟脂肪變性的作用,其機制可能與減輕體內脂質過氧化作用有關。
[Abstract]:Objective to investigate the effect and mechanism of eating bamboo charcoal powder charcoal powder on hyperlipidemia rats. Methods four weeks old male SD rats of SPF grade were randomly divided into five groups: blank control group, hyperlipidemia model control group and low and moderate BCP group. The rats in the high dose group were given the corresponding dose of bamboo charcoal powder or distilled water daily for 90 days. The blood of femoral artery was taken to determine the function of liver and kidney, and the liver, kidney and fat in both kidneys and around epididymis were weighed. The left lobe of the liver was taken for histopathological examination, and the liver homogenate was prepared. The contents of TCX, TGG, T-AOCN, CATX, SOD and MDAs were measured. Results the body weight of the hyperlipidemia model group was significantly higher than that of the control group from the 4th week. At the same time, the lipid / body ratio, serum alanine aminotransferase (alt) and very low density lipoprotein (VLDL) in the hyperlipidemia model control group were higher than those in the blank control group, and the steatosis was observed in the liver of the hyperlipidemia model control group. The contents of TC and TG in the liver were higher than those in the control group, which indicated that the weight, liver weight and lipid / body ratio were significantly decreased, serum alt TG and VLDL levels were decreased, and the degree of hepatic steatosis was decreased in each dose group compared with the hyperlipidemia control group. At the same time, the concentrations of TC and MDA in the liver also decreased the activities of SOD and CAT in the liver. Conclusion the edible bamboo charcoal powder can reduce the accumulation of fat, reduce the blood lipid and alleviate the hepatic steatosis in rats with hyperlipidemia. The mechanism may be related to the reduction of lipid peroxidation in vivo.
【作者單位】： 四川大學華西公共衛(wèi)生學院四川省食品安全監(jiān)測與風險評估重點實驗室;
【基金】：國家自然科學基金(No.81030053)
【分類號】：R151

【相似文獻】

相關期刊論文 前3條

1 鄧乾春;黃鳳洪;黃慶德;劉昌盛;鈕琰星;;冷榨薺藍油對高脂模型大鼠降血脂作用研究[J];營養(yǎng)學報;2009年04期

2 姜培珍,葉于薇,徐章華,邵玉芬;苦蕎營養(yǎng)粉的保健功能研究[J];中國食品衛(wèi)生雜志;1999年04期

3 ;[J];;年期

相關會議論文 前2條

1 趙明;王軍波;劉志剛;張佳麗;梁江;趙海峰;李瓊;張召鋒;李勇;;飲食核苷酸降血脂作用的研究[A];中國食品科學技術學會第八屆年會暨第六屆東西方食品業(yè)高層論壇論文摘要集[C];2011年

2 趙明;王軍波;劉志剛;張佳麗;梁江;趙海峰;李瓊;張召鋒;李勇;;飲食核苷酸降血脂作用的研究[A];北京市營養(yǎng)學會第四屆會員代表大會暨膳食與健康研討會論文集[C];2010年

，

本文編號：1686375