本文選題：酸馬奶　切入點：脾臟指數(shù)　出處：《細胞與分子免疫學雜志》2017年08期 　論文類型：期刊論文

【摘要】：目的探討酸馬奶對Wistar大鼠機體免疫功能的影響。方法無特定病原體(SPF)級Wistar大鼠24只,隨機分為空白組(2 m L/次生理鹽水灌胃)、酸馬奶灌胃組(2 m L/次),每組8只。灌胃4周后,無菌解剖取脾臟并測定脾臟指數(shù);噻唑藍(MTT)比色法檢測T、B淋巴細胞增殖;流式細胞術測定全血中CD3~+T細胞、CD4~+CD25~+T細胞百分比。結果酸馬奶灌胃大鼠的脾臟指數(shù)、淋巴細胞增殖率、全血中CD3~+T細胞百分比均高于空白組,CD4~+CD25~+T細胞百分比顯著低于空白組。結論酸馬奶可促進脾臟內淋巴細胞、全血中T、B細胞的增殖,抑制CD4~+CD25~+T細胞的分化,可調節(jié)機體免疫狀態(tài)。
[Abstract]:Objective to investigate the effect of yoghurt on the immune function of Wistar rats. Methods Twenty-four Wistar rats with no specific pathogen were randomly divided into two groups: the blank group (n = 8) and the control group (n = 8). The spleen was dissected and the spleen index was measured by aseptic dissection; the proliferation of T cell was detected by MTT colorimetry; and the percentage of CD4 ~ CD25 ~ T cells in whole blood was measured by flow cytometry. Lymphocyte proliferation rate and percentage of CD3T cells in whole blood were significantly lower than those in blank group. Conclusion yoghurt can promote the proliferation of splenic lymphocytes, and inhibit the differentiation of CD4 ~ CD25 ~ T cells in whole blood. Can adjust the immune state of the body.
【作者單位】： 內蒙古農業(yè)大學獸醫(yī)學院;農業(yè)部動物臨床診療技術重點實驗室;呼和浩特市易司貝牧業(yè)科技有限公司;內蒙古農業(yè)大學動物科學學院;
【基金】：產(chǎn)學研協(xié)同創(chuàng)新科技合作項目 內蒙古自治區(qū)高等學�？茖W研究項目(NJZC16064)
【分類號】：R151

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