本文選題：塵肺　切入點：矽肺　出處：《臨床醫(yī)藥實踐》2016年08期 　論文類型：期刊論文

【摘要】：目的:評價漢防己甲素治療塵肺(矽肺)的臨床療效。方法:在Pub Med,EMBASE,CENTRAL,CBM,CNKI及VIP和萬方等數(shù)據(jù)庫中檢索2000年1月—2015年5月關于漢防己甲素治療塵肺的臨床對照試驗,然后對其進行篩選和質量評價,并對符合標準的文獻進行Meta分析。結果:納入17項研究,共1 194例塵肺患者,漢防己甲素治療組臨床療效有效率、部分肺功能[一秒呼氣容積(FEV1),殘氣量/肺總量(RV/TLC)]、部分免疫細胞表達(CD4,CD8,CD4/CD8)與對照組對比,差異有統(tǒng)計學意義(P0.05)。但在免疫細胞表達CD3、臨床癥狀積分(咳嗽、咳痰、胸痛、呼吸困難)、肺功能[用力肺活量(FVC)、一秒呼氣容積/用力肺活量(FEV1/FVC)、肺活量(VC)]方面漢防己甲素治療組與對照組相比有改善的趨勢,但差異無統(tǒng)計學意義(P0.05)。結論:與對照組相比,漢防己甲素可以在一定程度上提高塵肺治療的臨床療效、部分免疫功能及肺功能。但在改善臨床癥狀方面效果不顯著,仍需開展更多高質量的多中心、大樣本、前瞻性、隨機、雙盲臨床試驗加以驗證。
[Abstract]:Objective: to evaluate the clinical efficacy of Tetrandrine in the treatment of pneumoconiosis (silicosis). Methods: a controlled clinical trial of Tetrandrine in the treatment of pneumoconiosis from January 2000 to May 2015 was conducted in the databases of Pub Medmella, VIP and Wanfang. Then screening and quality evaluation were carried out, and Meta analysis was carried out on the literature that met the standard. Results: in 17 studies, 1 194 patients with pneumoconiosis were treated with Tetrandrine (Tetrandrine). Part of lung function [1 second expiratory volume of FEV1, residual volume / total lung volume of RV / TLC], partial immunocyte expression of CD4 + CD8 / CD8 / CD8) compared with control group, there were significant differences in the expression of CD3, clinical symptom score (cough, expectoration, chest pain) between the two groups (P 0.05), but the expression of CD3 in immune cells was significantly higher than that in control group (P < 0.05). In terms of dyspnea, pulmonary function [forced vital capacity / forced vital capacity / FEV 1 / FVC], Tetrandrine treatment group showed an improved trend compared with control group, but the difference was not statistically significant (P 0.05). Conclusion: compared with control group, Tetrandrine treatment group has a tendency to improve. Tetrandrine can improve the clinical efficacy, immune function and lung function of pneumoconiosis to a certain extent. However, the effect of Tetrandrine on improving clinical symptoms is not significant. Double blind clinical trials were performed.
【作者單位】： 贛州市第五人民醫(yī)院;
【分類號】：R135.2

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