【摘要】：目的探討早期喉癌手術陰性切緣組織中PCNA、COX-2的表達與腫瘤局部復發(fā)的關系。方法選擇63例經CO2激光手術治療后的早期喉癌患者標本,對切除的腫瘤組織及切緣組織中PCNA、COX-2表達進行檢測,所有患者均隨訪2年以上,對其生存及腫瘤復發(fā)情況進行觀察。結果 63例早期喉癌患者腫瘤組織中PCNA、COX-2陽性率分別為73.02%、71.43%;切緣組織中PCNA和COX-2陽性率分別為33.33%、30.16%。腫瘤組織與切緣組織中PCNA、COX-2均陽性的患者分別為41例和13例,陽性率分別為65.08%、20.63%;63例隨訪病例中,局部復發(fā)17例,復發(fā)率為26.98%。PCNA陽性患者復發(fā)率為71.43%,COX-2陽性患者復發(fā)率為73.68%(P0.05)。聯(lián)合檢測PCNA和COX-2陽性者復發(fā)率明顯高于單獨陽性者(P0.05)。結論早期喉癌手術切緣組織中PCNA、COX-2的表達是喉癌患者預后的重要生物學標志,并可根據檢查結果制定針對性的后續(xù)治療方案,聯(lián)合檢測二者對術后治療具有更可靠的指導意義。
[Abstract]:Objective to investigate the relationship between the expression of PCNA,COX-2 in negative margin of early laryngeal carcinoma and local recurrence of laryngeal carcinoma. Methods the expression of PCNA,COX-2 was detected in 63 cases of early laryngeal carcinoma treated by CO2 laser. All the patients were followed up for more than 2 years. The survival and tumor recurrence were observed. Results the positive rates of PCNA,COX-2 and COX-2 in 63 patients with early laryngeal carcinoma were 73.02% and 41.43% respectively, and those in incised margin tissues were 33.33% and 30.16%, respectively. The positive rate of PCNA,COX-2 was 65.08% and 20.63% in 41 cases and 13 cases of tumor tissue and incisor margin tissue, respectively, and the positive rate was 65.08% and 20.63%, respectively. The recurrence rate of 26.98%.PCNA positive patients was 71.43%, and that of Cox-2 positive patients was 73.68% (P0.05). The recurrence rate of PCNA and COX-2 positive group was significantly higher than that of single positive group (P 0.05). Conclusion the expression of PCNA,COX-2 in the surgical margin of early laryngeal carcinoma is an important biological marker for prognosis of laryngeal carcinoma, and it can be used as a follow-up therapy according to the results of examination. Combined detection has more reliable guiding significance for postoperative treatment.
【作者單位】： 河北省唐山市協(xié)和醫(yī)院病理科;河北省唐山市人民醫(yī)院放化科;
【分類號】：R739.65

【參考文獻】

相關期刊論文 前1條

1 丁煥然;姜廣建;馬小兵;苗麗娟;夏慶安;馬立人;;肺癌組織中HSG、p21和PCNA的表達及意義[J];臨床與實驗病理學雜志;2009年02期

【共引文獻】

相關期刊論文 前10條

1 帥榮;黃棟;吳先玉;黃曉玲;周玖英;張杰;;抗核抗體譜中特異性抗體的臨床應用分析[J];國際檢驗醫(yī)學雜志;2013年20期

2 郭桃英;潘玫;;卵巢上皮性癌組織中線粒體融合蛋白2與VEGF的表達及其臨床意義[J];南昌大學學報(醫(yī)學版);2010年12期

3 韓軍;向靖;陸友金;;HnRNP A2/B1及p21WAF1蛋白在非小細胞肺癌中表達及意義[J];臨床肺科雜志;2011年03期

4 周開梅;郭瑞珍;陳世玖;;皮膚瘢痕及瘢痕癌組織中cyclin A、p21~(WAF1)的表達及意義[J];臨床與實驗病理學雜志;2011年07期

5 田芳;王sピ，

本文編號：2472089