白酒對家兔眼壓的影響
發(fā)布時間：2018-12-10 13:17
【摘要】：目的 探討家兔使用白酒灌胃后對眼壓的影響,并比較不同劑量白酒對眼壓的影響有無差異性,以便為研究人類飲酒后對眼壓的影響提供參考。 材料與方法 健康成年家兔48只,完全隨機(jī)分為A、B、C、D四組,其中A、B、C為實(shí)驗(yàn)組,D為對照組。以酒精度為56%(v/v)的白酒,分別按照不同的劑量對實(shí)驗(yàn)組灌胃:A組,2.5ml/kg;B組,5ml/kg;C組,7.5ml/kg,而對照組則灌以相應(yīng)劑量的蒸餾水,并分別命名為Da、Db和Dc。采用Tono-Pen XL眼壓計(jì)進(jìn)行眼壓測量。實(shí)驗(yàn)前測定固定時間點(diǎn)的多次眼壓值作為基線值。灌胃實(shí)驗(yàn)開始前,先測量實(shí)驗(yàn)組與對照組的眼壓值,并以該時刻作為初始時間點(diǎn)(0時刻)。立即對各實(shí)驗(yàn)組和對照組按相應(yīng)的劑量以白酒和蒸餾水灌胃,灌胃后分別在0.5h、1.0h、1.5h、2.0h、2.5h、3.5h各時間點(diǎn)測量眼壓。應(yīng)用SPSS17軟件包對實(shí)驗(yàn)前后所測眼壓數(shù)據(jù)以及基線值數(shù)據(jù)進(jìn)行統(tǒng)計(jì)分析和比較,分析白酒對家兔眼壓的影響以及灌胃劑量的不同所產(chǎn)生的差異。 結(jié)果 利用SPSS17軟件包進(jìn)行單因素重復(fù)測量方差分析。A、B、C、D四組家兔間眼壓的基線值相比:F=0.483;P0.05,無統(tǒng)計(jì)學(xué)差異。對照組Da、Db、Dc與D組的基線值相比:F=0.03;P0.05,無統(tǒng)計(jì)學(xué)差異。實(shí)驗(yàn)組中A組與對照組Da相比:F=0.255;P0.05,無統(tǒng)計(jì)學(xué)差異。實(shí)驗(yàn)組中B組與對照組Db相比:F=2.910;P0.05,且在0~1.0h之間家兔的眼壓呈下降趨勢,在1.0h處有明顯差異,1.0~2.5h處開始明顯回升。實(shí)驗(yàn)組中C組與對照組Dc相比:F=5.771;P0.05,且在0~1.5h之間呈下降趨勢,在1.0h、1.5h、2.0h處有統(tǒng)計(jì)學(xué)差異。 結(jié)論 以劑量為5.0ml/kg(中劑量組)和7.5ml/kg(高劑量組)的白酒對家兔灌胃后,眼壓在一定時間內(nèi)有明顯下降趨勢。隨著時間的延長,眼壓逐步回升,劑量越大,降壓幅度越大且較低眼壓維持時間越長。而以2.5ml/kg(低劑量組)的白酒對家兔灌胃后,無明顯的降壓作用。同時由Da、Db、Db的比較結(jié)果表明,本實(shí)驗(yàn)中影響眼壓值的因素為白酒,與蒸餾水(溶劑)無相關(guān)性。
[Abstract]:Objective to study the effect of different doses of liquor on intraocular pressure (IOP) in rabbits, and to provide a reference for the study of the effect of drinking liquor on IOP in rabbits. Materials and methods Forty-eight healthy adult rabbits were randomly divided into four groups: Acarb C as experimental group and D as control group. In the experiment group, 56% (v / v) liquor was given to the experimental group according to different doses: group A, group B, 2.5 ml / kg, 5 ml / kg; Group C, 7.5 ml / kg, while the control group was given distilled water of the corresponding dose, named Da,Db and Dc., respectively. The intraocular pressure was measured by Tono-Pen XL IOP meter. The intraocular pressure (IOP) at a fixed time point was measured as the baseline value before the experiment. The intraocular pressure (IOP) of the experimental group and the control group was measured before the gavage experiment, and the time was taken as the initial time point (time 0). The rats in each experimental group and control group were immediately treated with distilled water and liquor at the corresponding dosage. Intraocular pressure was measured at 0.5 h, 1.0 h, 1.5 h, 2.0 h, 2.5 h and 3.5 h, respectively. The intraocular pressure data and baseline data before and after the experiment were statistically analyzed and compared by SPSS17 software package. The effects of liquor on intraocular pressure in rabbits and the difference between the dosages of intragastric perfusion were analyzed. Results single factor repeated analysis of variance was carried out by using SPSS17 software package. The baseline values of IOP in the four groups were compared with each other: FG 0.483U P0.05. there was no statistical difference between the four groups. The baseline value of Da,Db,Dc in control group was not significantly different from that in group D (P 0.05). There was no significant difference in Da between group A and control group (P 0.05). Compared with the control group, the intraocular pressure (IOP) of group B was lower than that of the control group (P 0.05), and the IOP of group B decreased between 0 h and 1.0 h, and the intraocular pressure increased significantly at 1.0 h and 2.5 h, respectively. Compared with the control group, the Dc of group C was 5.771g / ml (P0.05), and it showed a decreasing trend between 0 and 1.5h, and there was a statistical difference at 1.0hs, 1.5h and 2.0h. Conclusion the intraocular pressure (IOP) of 5.0ml/kg (middle dose group) and 7.5ml/kg (high dose group) were significantly decreased after intragastric perfusion in rabbits. With the prolongation of time, intraocular pressure gradually increased, the larger the dose, the greater the amplitude of lowering blood pressure and the longer the duration of lower IOP. However, 2.5ml/kg (low dose group) liquor had no obvious antihypertensive effect on rabbits. At the same time, the results of Da,Db,Db showed that the factor affecting IOP in this experiment was liquor, which had no correlation with distilled water (solvent).
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2011
【分類號】：R77
本文編號：2370635
[Abstract]:Objective to study the effect of different doses of liquor on intraocular pressure (IOP) in rabbits, and to provide a reference for the study of the effect of drinking liquor on IOP in rabbits. Materials and methods Forty-eight healthy adult rabbits were randomly divided into four groups: Acarb C as experimental group and D as control group. In the experiment group, 56% (v / v) liquor was given to the experimental group according to different doses: group A, group B, 2.5 ml / kg, 5 ml / kg; Group C, 7.5 ml / kg, while the control group was given distilled water of the corresponding dose, named Da,Db and Dc., respectively. The intraocular pressure was measured by Tono-Pen XL IOP meter. The intraocular pressure (IOP) at a fixed time point was measured as the baseline value before the experiment. The intraocular pressure (IOP) of the experimental group and the control group was measured before the gavage experiment, and the time was taken as the initial time point (time 0). The rats in each experimental group and control group were immediately treated with distilled water and liquor at the corresponding dosage. Intraocular pressure was measured at 0.5 h, 1.0 h, 1.5 h, 2.0 h, 2.5 h and 3.5 h, respectively. The intraocular pressure data and baseline data before and after the experiment were statistically analyzed and compared by SPSS17 software package. The effects of liquor on intraocular pressure in rabbits and the difference between the dosages of intragastric perfusion were analyzed. Results single factor repeated analysis of variance was carried out by using SPSS17 software package. The baseline values of IOP in the four groups were compared with each other: FG 0.483U P0.05. there was no statistical difference between the four groups. The baseline value of Da,Db,Dc in control group was not significantly different from that in group D (P 0.05). There was no significant difference in Da between group A and control group (P 0.05). Compared with the control group, the intraocular pressure (IOP) of group B was lower than that of the control group (P 0.05), and the IOP of group B decreased between 0 h and 1.0 h, and the intraocular pressure increased significantly at 1.0 h and 2.5 h, respectively. Compared with the control group, the Dc of group C was 5.771g / ml (P0.05), and it showed a decreasing trend between 0 and 1.5h, and there was a statistical difference at 1.0hs, 1.5h and 2.0h. Conclusion the intraocular pressure (IOP) of 5.0ml/kg (middle dose group) and 7.5ml/kg (high dose group) were significantly decreased after intragastric perfusion in rabbits. With the prolongation of time, intraocular pressure gradually increased, the larger the dose, the greater the amplitude of lowering blood pressure and the longer the duration of lower IOP. However, 2.5ml/kg (low dose group) liquor had no obvious antihypertensive effect on rabbits. At the same time, the results of Da,Db,Db showed that the factor affecting IOP in this experiment was liquor, which had no correlation with distilled water (solvent).
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2011
【分類號】：R77
【參考文獻(xiàn)】
相關(guān)期刊論文 前4條
1 賈莉君，蔣幼芹，，吳振中;兔眼壓正常值與前房穿刺直接測量法[J];眼科研究;1994年04期
2 汪寧,彭智培,范寶劍,劉瑤,董曉梅,梁旭輝,欒潔;我國原發(fā)性開角型青光眼危險(xiǎn)因素的病例對照研究[J];中華流行病學(xué)雜志;2002年04期
3 何明光,許京京,吳開力,李紹珍;斗門縣農(nóng)村中老年人群原發(fā)閉角性青光眼流行病學(xué)調(diào)查[J];中山醫(yī)科大學(xué)學(xué)報(bào);2000年03期
4 江冰,蔣幼芹;Tono-pen眼壓計(jì)在眼科的應(yīng)用[J];中國實(shí)用眼科雜志;2000年03期
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