不同分期糖尿病視網(wǎng)膜病變淚液TNF-α的表達(dá)
[Abstract]:Objective to determine and compare the content of tumor necrosis factor- 偽 (TNF- 偽) in tears of patients with different stages of type 2 diabetes mellitus and normal subjects, and to explore the relationship between TNF- 偽 and diabetic retinopathy. To determine the correlation between TNF- 偽 in tear and serum TNF- 偽 level. Methods 50 cases of normal control group (NC group), 50 cases of type 2 diabetic non-retinopathy group (NDR group), 50 cases of type 2 diabetic simple retinopathy group (DR group), 50 cases of type 2 diabetic proliferative retinopathy group (PDR group), 50 cases of normal control group (NC group), 50 cases of type 2 diabetic non-retinopathy group (NDR group), 50 cases of type 2 diabetic proliferative retinopathy group (PDR group) were examined by ELISA method. The content of TNF- 偽 in serum. Results the content of TNF- 偽 in tears was (0.48 鹵0.17) pg/ml,NDR, (3.84 鹵1.64) pg/ml,DR, (6.63 鹵2.06), (7.76 鹵3.05) pg/ml, in NC group and (7.76 鹵3.05) pg/ml, respectively (P0.01 or P0.05). The concentration of TNF- 偽 in serum of NC group was (4.78 鹵3.03) pg/ml,NDR group was (13.68 鹵6.66) pg/ml,DR group was (18.92 鹵5.94) pg/ml,PDR group was (21.62 鹵9.92) pg/ml, group (P0.01). There was a correlation between serum TNF- 偽 and tear TNF- 偽 (r = 0.751P 0.05). Conclusion the level of TNF- 偽 in tears of patients with type 2 diabetes mellitus is significantly increased. With the severity of diabetic retinopathy, the content of TNF- 偽 in tear increased gradually, suggesting that the level of TNF- 偽 in tear was related to the occurrence of diabetes mellitus and diabetic retinopathy in different stages. There was a linear positive correlation between serum TNF- 偽 and serum TNF- 偽 level.
【作者單位】： 石家莊市第三醫(yī)院眼科;石家莊市第一醫(yī)院內(nèi)分泌科;石家莊市第一醫(yī)院干部老年病科;石家莊市第七醫(yī)院健康檢查科;
【基金】：石家莊市科學(xué)技術(shù)研究與發(fā)展指導(dǎo)計劃項目(No:111461293)
【分類號】：R587.2;R774.1
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