重復(fù)性眶周交流電刺激對(duì)單眼剝奪小鼠視皮層眼優(yōu)勢(shì)移動(dòng)的影響
發(fā)布時(shí)間：2018-07-21 17:54
【摘要】：目的觀察單眼剝奪小鼠視皮層對(duì)重復(fù)性眶周交流電刺激(r PACS)的反應(yīng),探討r PACS對(duì)弱視小鼠眼優(yōu)勢(shì)移動(dòng)的影響。方法將30只小鼠分為正常組、模型組、電刺激組,每組各10只。模型組、電刺激組采用單眼剝奪法建立單眼(右眼)弱視模型。造模后電刺激組右眼行r PACS 3 d;模型組及正常組不行r PACS。測(cè)定各組雙眼圖形視覺誘發(fā)電位(PVEP)、雙眼PVEP信號(hào)P100波的振幅和潛伏期,計(jì)算對(duì)側(cè)眼振幅/同側(cè)眼振幅(C/I)值。結(jié)果模型組右眼PVEP P100波振幅低于電刺激組及正常組,亦低于左眼(P均0.05);右眼PVEP P100波潛伏期長(zhǎng)于電刺激組及正常組,亦長(zhǎng)于左眼(P均0.05);右眼C/I低于電刺激組及正常組(P均0.01)。結(jié)論單眼剝奪后可使視覺發(fā)育敏感期內(nèi)的眼優(yōu)勢(shì)柱從剝奪眼轉(zhuǎn)移至對(duì)側(cè)眼,r PACS可使眼優(yōu)勢(shì)柱從對(duì)側(cè)眼轉(zhuǎn)移回剝奪眼。
[Abstract]:Objective to observe the response of visual cortex to repetitive periorbital alternating current stimulation (r PACS) in monocular deprived mice and to investigate the effect of r PACS on the dominant movement of amblyopia in mice. Methods Thirty mice were divided into normal group, model group and electric stimulation group with 10 mice in each group. Model group and electric stimulation group were used to establish monocular (right eye) amblyopia model. The right eye was treated with r PACS for 3 days in the model group, but not in the model group and the normal group. The amplitude and latency of P100 wave of binocular PVEP signal were measured, and the amplitude of contralateral eye and amplitude of ipsilateral eye (C / I) were calculated. Results the amplitude of PVEP P100 wave in the model group was lower than that in the electrical stimulation group and the normal group (P 0.05), the latency of PVEP P100 wave in the right eye was longer than that in the electrical stimulation group and the normal group (P 0.05), and the C / P I in the right eye was lower than that in the electrical stimulation group and the normal group (P 0.01). Conclusion single eye deprivation can transfer the dominant column from the deprived eye to the opposite side of the eye, which can transfer the dominant column from the opposite side of the eye to the other side of the eye.
【作者單位】： 天津醫(yī)科大學(xué)眼科臨床學(xué)院;天津市眼科醫(yī)院;天津市眼科研究所;天津市眼科學(xué)與視覺科學(xué)重點(diǎn)實(shí)驗(yàn)室;
【分類號(hào)】：R777.44
本文編號(hào)：2136320
[Abstract]:Objective to observe the response of visual cortex to repetitive periorbital alternating current stimulation (r PACS) in monocular deprived mice and to investigate the effect of r PACS on the dominant movement of amblyopia in mice. Methods Thirty mice were divided into normal group, model group and electric stimulation group with 10 mice in each group. Model group and electric stimulation group were used to establish monocular (right eye) amblyopia model. The right eye was treated with r PACS for 3 days in the model group, but not in the model group and the normal group. The amplitude and latency of P100 wave of binocular PVEP signal were measured, and the amplitude of contralateral eye and amplitude of ipsilateral eye (C / I) were calculated. Results the amplitude of PVEP P100 wave in the model group was lower than that in the electrical stimulation group and the normal group (P 0.05), the latency of PVEP P100 wave in the right eye was longer than that in the electrical stimulation group and the normal group (P 0.05), and the C / P I in the right eye was lower than that in the electrical stimulation group and the normal group (P 0.01). Conclusion single eye deprivation can transfer the dominant column from the deprived eye to the opposite side of the eye, which can transfer the dominant column from the opposite side of the eye to the other side of the eye.
【作者單位】： 天津醫(yī)科大學(xué)眼科臨床學(xué)院;天津市眼科醫(yī)院;天津市眼科研究所;天津市眼科學(xué)與視覺科學(xué)重點(diǎn)實(shí)驗(yàn)室;
【分類號(hào)】：R777.44
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