本文選題：阻塞性睡眠呼吸暫停低通氣綜合征 + 軟腭�。� 參考：《安徽醫(yī)科大學(xué)學(xué)報(bào)》2014年07期

【摘要】：目的研究阻塞性睡眠呼吸暫停低通氣綜合征(OSAHS)患者軟腭組織中蛋白基因產(chǎn)物9.5(PGP9.5)和神經(jīng)細(xì)胞黏附因子(NCAM)的表達(dá)及末梢神經(jīng)在軟腭各層組織中分布,探討OSAHS患者軟腭末梢神經(jīng)分布特點(diǎn)及調(diào)節(jié)的變化。方法選取30例OSAHS患者作為實(shí)驗(yàn)組,10例排除OSAHS的單純慢性扁桃體炎患者作為對(duì)照組。通過(guò)HE染色檢測(cè)軟腭組織中末梢神經(jīng)的分布,免疫組化檢測(cè)軟腭組織中PGP9.5和NCAM的表達(dá)。結(jié)果 1實(shí)驗(yàn)組軟腭不同層次組織中末梢神經(jīng)的分布不同,末梢神經(jīng)主要分布在黏膜下層、腺體、血管周?chē)?肌肉組織周?chē)倭糠植?2實(shí)驗(yàn)組OSAHS患者軟腭組織中PGP9.5及NCAM表達(dá)明顯高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);3 PGP9.5、NCAM的表達(dá)水平與呼吸暫停低通氣指數(shù)(AHI)呈正相關(guān)(r=0.706,P=0.01;r=0.636,P=0.01)。結(jié)論 OSAHS患者軟腭組織中末梢神經(jīng)的分布及支配異常,且與病情嚴(yán)重程度密切相關(guān)。
[Abstract]:Objective to study the expression of protein gene product 9.5 (PGP 9.5) and nerve cell adhesion factor (NCAM) in soft palate of patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and the distribution of peripheral nerves in different layers of soft palate. To investigate the distribution and regulation of soft palate peripheral nerves in patients with OSAHS. Methods 30 patients with OSAHS were selected as experimental group and 10 patients with simple chronic tonsillitis excluded from OSAHS as control group. The distribution of peripheral nerve in soft palate tissue was detected by HE staining and the expression of PGP 9.5 and NCAM in soft palate tissue was detected by immunohistochemistry. Results 1the distribution of peripheral nerves in different layers of soft palate in the experimental group was different. The peripheral nerves were mainly distributed in the submucosa, glands and blood vessels. The expression of PGP 9.5 and NCAM in soft palate tissue of OSAHS group was significantly higher than that of control group (P0.05). There was a positive correlation between the expression level of NCAM and apnea hypopnea index (AHI) (P < 0.05). Conclusion the distribution and innervation of peripheral nerves in soft palate of patients with OSAHS are abnormal and closely related to the severity of the disease.
【作者單位】： 安徽醫(yī)科大學(xué)解放軍八一臨床學(xué)院;解放軍八一醫(yī)院耳鼻咽喉頭頸外科;解放軍八一醫(yī)院病理科;
【基金】：南京軍區(qū)“十一五”科研創(chuàng)新課題(編號(hào):08MA05110MA047) 南京軍區(qū)“十二五”科研創(chuàng)新課題聯(lián)合資助項(xiàng)目(編號(hào):11MA052)
【分類(lèi)號(hào)】：R766

【參考文獻(xiàn)】

相關(guān)期刊論文 前7條

1 龔宏勛;劉鳳芳;陳賢明;張賢;;阻塞性睡眠呼吸暫停低通氣綜合征腭帆張肌失神經(jīng)變化[J];中國(guó)耳鼻咽喉頭頸外科;2010年05期

2 陳公平;林其昌;黃建釵;趙建銘;陳華;;阻塞性睡眠呼吸暫停低通氣綜合征患者血清腫瘤壞死因子-α、白細(xì)胞介素-6水平的檢測(cè)及臨床意義[J];福建醫(yī)科大學(xué)學(xué)報(bào);2010年05期

3 盧衛(wèi)琴;肖謙;;多唾液酸-神經(jīng)細(xì)胞黏附分子與認(rèn)知功能[J];國(guó)外醫(yī)學(xué)(老年醫(yī)學(xué)分冊(cè));2008年02期

4 陸立彥;盧曉峰;;OSAHS患者上氣道及周?chē)M織形態(tài)與功能改變的研究進(jìn)展[J];口腔頜面外科雜志;2009年05期

5 龔宏勛;陳賢明;張賢;劉鳳芳;;阻塞性睡眠呼吸暫停低通氣綜合征上氣道開(kāi)大肌凋亡現(xiàn)象研究[J];臨床耳鼻咽喉頭頸外科雜志;2010年03期

6 岳紅梅;黃會(huì)遠(yuǎn);呂燕;劉t，

本文編號(hào)：2115034