本文選題：結膜囊細菌培養(yǎng) + 內眼手術�。� 參考：《延邊大學》2010年碩士論文

【摘要】： 目的：通過比較單純抗生素滴眼液滴眼、聯(lián)合結膜囊沖洗和再聯(lián)合術前全身應用廣譜抗生素等三種措施后的結膜囊無菌化效果,探討內眼手術前全身預防性應用抗生素的必要性。 方法：隨機選擇200眼分為對照組(50眼)及實驗組(150眼)。實驗組隨機分為Ⅰ、Ⅱ、Ⅲ組,每組50眼。四組均在尚未干預結膜囊之前進行結膜囊細菌培養(yǎng)。其中對照組應用生理鹽水100ml沖洗；對第Ⅰ組50眼滴左氧氟沙星滴眼液,每天4次、連續(xù)滴3天后作結膜囊細菌培養(yǎng)；對第Ⅱ組50眼滴左氧氟沙星滴眼液并用生理鹽水100毫升沖洗結膜囊后作結膜囊細菌培養(yǎng)；對第Ⅲ組50眼滴3天左氧氟沙星滴眼液、靜脈點滴左氧氟沙星注射液100ml后1h時再用生理鹽水100毫升沖洗結膜囊后作結膜囊細菌培養(yǎng)。 結果：1.Ⅰ組50眼左氧氟沙星滴眼液滴眼前后結膜囊細菌培養(yǎng)陽性率分別為34.0%和12.0%,前后細菌培養(yǎng)陽性率差異有統(tǒng)計學意義(x2=6.832,P0.01)。2.第Ⅱ組50眼滴左氧氟沙星滴眼液3天并用生理鹽水100毫升沖洗結膜囊前后結膜囊細菌培養(yǎng)陽性率分別為38.0%和8.0%,前后細菌培養(yǎng)陽性率差異有統(tǒng)計學意義(x2=12.705,P0.01)。3.對第Ⅲ組50眼滴左氧氟沙星滴眼液、靜脈點滴左氧氟沙星注射液100ml后1h時再用生理鹽水100毫升沖洗結膜囊前后結膜囊細菌培養(yǎng)陽性率分別為36.0%和4.0%。采用三種聯(lián)合措施前后細菌培養(yǎng)陽性率差異有統(tǒng)計學意義(x2=16.000,P0.01)。4.Ⅰ、Ⅱ、Ⅲ組尚未干預結膜囊之前結膜囊細菌培養(yǎng)陽性率分別為34.0%、38.0%和36.0%,三組間差異無統(tǒng)計學意義(x2=0.174,P0.05);而Ⅰ、Ⅱ、Ⅲ組采取三種不同結膜囊無菌化措施后結膜囊細菌培養(yǎng)陽性率分別為12.0%、8.0%和4.0%,Ⅰ組和Ⅱ組、Ⅱ組和Ⅲ組間差異有統(tǒng)計學意義(x2=10.606,P0.01)。 結論：1.內眼術前使用左氧氟沙星和生理鹽水沖洗結膜囊,是內眼手術前預防眼內感染的有效措施,可常規(guī)實施。2.術前1h靜脈使用左氧氟沙星注射液可明顯提高結膜囊細菌清除率,有助于預防內眼手術后眼內感染。
[Abstract]:Objective: To explore the aseptic effect of the conjunctival sac after three measures such as simple antibiotic drop eye drops, combined conjunctival sac flushing and reunion of broad spectrum antibiotics before operation, and to explore the necessity of systemic antibiotic application before operation.
Methods: randomly selected 200 eyes were divided into control group (50 eyes) and experimental group (150 eyes). The experimental group was randomly divided into group I, group II, group III and 50 eyes in each group. The four groups were cultured in conjunctival sac before the conjunctival sac was not intervened. The control group was washed with saline 100ml, and 50 eyes drop left Ofloxacin Eye Drops, 4 times a day, 3 in group I. The bacterial culture of conjunctival sac was made in the second group; 50 eyes drop left Ofloxacin Eye Drops and 100 ml of normal saline were used to develop conjunctival sac for bacterial culture. 3 days of 3 days left Ofloxacin Eye Drops in group 50, and after intravenous drip of Levofloxacin Injection 100ml after intravenous drip of 100 ml of normal saline, after the conjunctival sac was used as a knot. Culture of membrane capsule bacteria.
Results: the positive rate of bacterial culture of conjunctival sac before and after 1. eyes of 50 eyes in group 1. I was 34% and 12% respectively. The positive rate of the positive rate of bacterial culture before and after was statistically significant (x2=6.832, P0.01).2., group II, 50, 50 eyes, left Ofloxacin Eye Drops, 3 days and the culture of conjunctival sac before and after the conjunctival sac of 100 ml of physiological saline The rate of sex was 38% and 8% respectively. The positive rate of the positive rate of bacteria culture before and after was statistically significant (x2=12.705, P0.01).3. to group III, 50 eyes drop left Ofloxacin Eye Drops, intravenous drip of Levofloxacin Injection 100ml after 1h and 100 ml of physiological saline rinse conjunctival sac before and after the conjunctival sac bacteria culture positive rate was 36% and 4.0%. adopted, respectively. There was significant difference in the positive rate of bacterial culture before and after the three measures (x2=16.000, P0.01).4. I, II, group II, group III before the conjunctival sac bacteria culture positive rates were 34%, 38% and 36%, respectively, there was no statistical difference between the three groups (x2=0.174, P0.05); and I, II, III group adopted three different conjunctival sac aseptic measures The positive rates of bacterial culture in posterior conjunctival sac were 12%, 8% and 4%, respectively. There was significant difference between group II and group II, group II and group III (x2=10.606, P0.01).
Conclusion: 1. the treatment of conjunctival sac by using levofloxacin and saline before internal ophthalmic operation is an effective measure to prevent intraocular infection before internal ocular surgery. The routine implementation of 1H intravenous Levofloxacin Injection before.2. can obviously improve the bacterial clearance rate of conjunctival sac and help prevent intraocular infection after internal eye operation.
【學位授予單位】：延邊大學
【學位級別】：碩士
【學位授予年份】：2010
【分類號】：R779.6

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