發(fā)布時(shí)間：2019-05-13 20:23

【摘要】：目的探討冠脈造影患者高密度脂蛋白(High-density lipoprotein,HDL)亞類對(duì)冠狀動(dòng)脈狹窄程度影響的相關(guān)性。方法(1)、抽取2013年-2014年因疑診冠心病(Coronary Heart Disease,CHD)入住我院老年醫(yī)學(xué)科、心內(nèi)科行冠狀動(dòng)脈造影(Coronary arteriography,CAG)的患者122例,經(jīng)選擇性冠狀動(dòng)脈造影確診為CHD患者(至少有一支冠狀動(dòng)脈或分支狹窄50%)96例,其中男62例,女34例,平均年齡(60.31±8.72),未診斷CHD患者26例,男10例,女16例,平均年齡(59.00±13.51);(2)、抽取患者空腹12 h靜脈血,選擇雙向電泳-免疫印跡檢測法24h內(nèi)測定HDL亞類,對(duì)患者冠脈造影結(jié)果(采用Gensini評(píng)分)評(píng)價(jià)冠狀動(dòng)脈狹窄程度;(3)、計(jì)量資料用均數(shù)±標(biāo)準(zhǔn)差(?X±s)表示,定性資料用Χ2檢驗(yàn),兩組比較采用獨(dú)立樣本的t檢驗(yàn),logisitic回歸分析檢驗(yàn)與冠心病相關(guān)因素,兩因素相關(guān)性采用線性相關(guān)分析。結(jié)果(1)單因素卡方、兩樣本獨(dú)立t檢驗(yàn)顯示性別、吸煙史、糖尿病史、收縮壓、體質(zhì)指數(shù)(Body Mass Index,BMI)、腰圍(Waist circuit,WC)、腰臀比(waist to hip ratio,WHR)、HDL-C、LDL-C、Apo A-I、Lpa、Preb1-HDL、HDL3b、HDL3c、HDL2b與冠心病有關(guān),差異有統(tǒng)計(jì)學(xué)意義(P0.05);(2)TG、Preb1-HDL、HDL3b是冠心病危險(xiǎn)因素,HDL2b是冠心病保護(hù)因素(P0.05);(3)HDL2b與Gensini評(píng)分結(jié)果成負(fù)相關(guān),Preb1-HDL、HDL3b與Gensini評(píng)分結(jié)果成正相關(guān)。結(jié)論在臨床診斷治療中,HDL2b值有可能做為冠心病預(yù)測因素,Preβ1-HDL、HDL3b、HDL2b值可為預(yù)測和診斷CHD提供重要依據(jù),冠心病的防治不僅要改善和促進(jìn)膽固醇逆轉(zhuǎn)運(yùn)還要調(diào)節(jié)血脂,還要調(diào)整HDL亞類的構(gòu)成比。。但本組研究病例數(shù)量較少,隨訪時(shí)間較短,仍需更多病例長期隨訪來綜合評(píng)價(jià)其臨床效果。
[Abstract]:Objective to investigate the effect of high density lipoprotein (High-density lipoprotein,HDL) subclasses on the degree of coronary artery stenosis in patients with coronary angiography. Methods (1) from 2013 to 2014, 122 patients with suspected coronary heart disease (Coronary Heart Disease,CHD) admitted to the department of geriatrics and underwent coronary angiography (Coronary arteriography,CAG) in our hospital. 96 patients with CHD (at least one coronary artery or branch stenosis 50%) were diagnosed by selective coronary angiography, including 62 males and 34 females with an average age of 60.31 鹵8.72. There were 26 patients with undiagnosed CHD, 10 males and 16 females. The average age was 59.00 鹵13.51). (2) the fasting venous blood of the patients was taken for 12 hours, and the HDL subclasses were measured within 24 hours by two-dimensional electrophoresis and immunoblotting. The coronary angiography results (Gensini score) were used to evaluate the degree of coronary artery stenosis. (3) the econometric data were expressed by mean 鹵standard deviation (? X 鹵s), the qualitative data were tested by X 2 test, the two groups were compared with t test of independent samples, logisitic regression analysis was used to test the related factors of coronary heart disease, and linear correlation analysis was used to analyze the correlation between the two factors. Results (1) single factor chi square, two sample independent t test showed sex, smoking history, diabetes history, systolic blood pressure, body mass index (Body Mass Index,BMI), waist circumference (Waist circuit,WC), waist hip ratio (waist to hip ratio,WHR), HDL-C,. LDL-C,Apo A 鈮，

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