【摘要】：目的探討免疫性血小板減少癥(ITP)患者調(diào)節(jié)性T淋巴細(xì)胞(Treg)比例和T細(xì)胞表面白細(xì)胞相關(guān)免疫球蛋白樣受體1(LAIR-1)的表達(dá)以及血清可溶性LAIR-1(s LAIR-1)、s LAIR-2水平。方法選取ITP患者45例(ITP組)和同期健康體檢的兒童35例(對(duì)照組),采用流式細(xì)胞術(shù)檢測(cè)兩組外周血CD4+CD25+Treg比例及LAIR-1在Treg表面的表達(dá),ELISA檢測(cè)血清中s LAIR-1和s LAIR-2水平。結(jié)果 ITP組患者外周血Treg比率明顯低于對(duì)照組,ITP組和對(duì)照組CD4+CD25+Treg和CD8+T細(xì)胞膜LAIR-1表達(dá)率無(wú)顯著性差異,ITP組血清s LAIR-1和s LAIR-2明顯高于對(duì)照組。結(jié)論 LAIR-1可能通過(guò)影響CD4+CD25+T細(xì)胞在ITP發(fā)病過(guò)程起關(guān)鍵作用,LAIR-2可部分抑制LAIR-1的功能。
[Abstract]:Objective to investigate the ratio of (Treg) on regulatory T lymphocytes and the expression of leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) on T cells and serum soluble LAIR-1 (s LAIR-1) in patients with immune thrombocytopenia (ITP). S LAIR-2 level. Methods 45 patients with ITP (ITP group) and 35 healthy children (control group) were selected. The ratio of CD4 CD25 Treg in peripheral blood and the expression of LAIR-1 on the surface of Treg in the two groups were detected by flow cytometry. The levels of s-LAIR-1 and s-LAIR-2 in serum were detected by ELISA. Results the ratio of Treg in ITP group was significantly lower than that in control group. There was no significant difference in the expression rate of CD4 CD25 Treg and CD8 T membrane LAIR-1 between ITP group and control group. The levels of s LAIR-1 and s LAIR-2 in ITP group were significantly higher than those in control group. Conclusion LAIR-1 may play a key role in the pathogenesis of ITP by affecting CD4 CD25 T cells. LAIR-2 can partially inhibit the function of LAIR-1.
【作者單位】： 平頂山學(xué)院醫(yī)學(xué)院;天津市中醫(yī)藥研究院附屬醫(yī)院;
【分類號(hào)】：R558.2
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本文編號(hào)：2430715