【摘要】：探討人附睪蛋白4(HE4)對(duì)急性心力衰竭患者預(yù)后的預(yù)測(cè)價(jià)值。入組2015年1月~2016年2月住院的急性心力衰竭患者178例,檢測(cè)患者血清中HE4的表達(dá)水平,并對(duì)患者進(jìn)行隨訪(fǎng),記錄患者死亡和再住院情況。HE4在心力衰竭組明顯高于健康對(duì)照組[(7.8±0.6)ng/ml vs.(2.2±0.5)ng/ml,P0.05)],且隨心功能分級(jí)的惡化,HE4水平明顯升高[(5.3±0.4)ng/ml vs.(7.6±0.5)ng/ml vs.(9.7±0.6)ng/ml,P0.05)],多因素Cox生存分析表明:HE4是預(yù)測(cè)急性心力衰竭患者預(yù)后的獨(dú)立預(yù)測(cè)指標(biāo)(χ2=10.26,HR95%CI:2.25(0.67~4.14),P0.001),進(jìn)一步分析顯示:HE47.5ng/ml的患者死亡和再入院的風(fēng)險(xiǎn)是HE4≤7.5ng/ml的患者的7.12倍。HE4能夠反映急性心力衰竭的嚴(yán)重程度,并且能夠預(yù)測(cè)急性心力衰竭患者的預(yù)后。
[Abstract]:To investigate the prognostic value of human epididymal protein 4 (HE4) in patients with acute heart failure. From January 2015 to February 2016, 178 patients with acute heart failure were enrolled in the study. The expression of HE4 in serum was detected, and the patients were followed up. HE4 in heart failure group was significantly higher than that in healthy control group [(7.8 鹵0.6) ng/ml vs. (2.2 鹵0.5) ng/ml,P0.05], and it deteriorated with cardiac function grade. The level of HE4 was significantly increased [(5.3 鹵0.4) ng/ml vs. (7.6 鹵0.5) ng/ml vs. (9.7 鹵0.6) ng/ml,P0.05]. Multivariate Cox survival analysis showed that HE4 was an independent predictor of prognosis in patients with acute heart failure (蠂 2 / 10.26 / HR95 CI: 2.25 (0.674.14), P0.001). Further analysis showed that the risk of death and readmission in patients with HE47.5ng/ml was 7.12 times higher than that in patients with HE4 鈮，

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