骨髓增生異常綜合征中染色體畸變類型
發(fā)布時間:2018-07-21 11:57
【摘要】:正骨髓增生異常綜合征(myelodysplastic syndromes,MDS)是一類起源于骨髓造血干細胞的惡性克隆性疾病,具有明顯的異質性,其特征是骨髓病態(tài)造血,細胞減少,骨髓一系或多系異型增生。臨床表現(xiàn)主要為貧血、出血、感染等,容易發(fā)展為急性髓細胞性白血病(acute myeloid leu-kemia,AML)~[1]。MDS多見于老年人,平均發(fā)病年齡70歲。總體發(fā)病率為3~5/100 000,而70歲以上人群的發(fā)病率上升到大于20/100 000~[2]。染色體畸變在MDS的發(fā)生發(fā)展
[Abstract]:Normal myelodysplastic syndrome (myelodysplastic syndromes) is a kind of malignant clonal disease originating from bone marrow hematopoietic stem cells. It has obvious heterogeneity. It is characterized by morbid hematopoiesis, cytopenia and dysplasia of one or more lines of bone marrow. The main clinical manifestations were anemia, hemorrhage, infection, etc. It was easy to develop acute myeloid leukemia (acute myeloid leu-kemiaAML) ~ [1] .MDS was more common in the elderly, with an average age of 70 years. The overall incidence was 3 / 5 / 100, 000, while the incidence of people over 70 increased to more than 20 / 100, 000 ~ [2]. Development of chromosome aberration in MDS
【作者單位】: 武漢大學人民醫(yī)院腫瘤中心;
【基金】:國家自然科學基金資助項目(編號:81670123) 湖北省自然科學基金資助項目(編號:2014CKB493)
【分類號】:R551.3
本文編號:2135448
[Abstract]:Normal myelodysplastic syndrome (myelodysplastic syndromes) is a kind of malignant clonal disease originating from bone marrow hematopoietic stem cells. It has obvious heterogeneity. It is characterized by morbid hematopoiesis, cytopenia and dysplasia of one or more lines of bone marrow. The main clinical manifestations were anemia, hemorrhage, infection, etc. It was easy to develop acute myeloid leukemia (acute myeloid leu-kemiaAML) ~ [1] .MDS was more common in the elderly, with an average age of 70 years. The overall incidence was 3 / 5 / 100, 000, while the incidence of people over 70 increased to more than 20 / 100, 000 ~ [2]. Development of chromosome aberration in MDS
【作者單位】: 武漢大學人民醫(yī)院腫瘤中心;
【基金】:國家自然科學基金資助項目(編號:81670123) 湖北省自然科學基金資助項目(編號:2014CKB493)
【分類號】:R551.3
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