本文選題：系統(tǒng)性紅斑狼瘡 + 肺動脈高壓　； 參考：《新疆醫(yī)科大學(xué)》2015年碩士論文

【摘要】：目的：通過分析系統(tǒng)性紅斑狼瘡(systemic lupus erythematosus,SLE)合并肺動脈高壓(pulmonary arterial hypertension, PAH)的臨床特點(diǎn),討論P(yáng)AH在SLE中的致病原因、相關(guān)臨床特征及預(yù)后影響因素,從而提高對SLE繼發(fā)PAH的認(rèn)識。方法：回顧性總結(jié)分析2008年1月至2014年1月期間,在新疆醫(yī)科大學(xué)第一附屬醫(yī)院皮膚科及風(fēng)濕免疫科住院的187例SLE患者中83例經(jīng)心臟超聲多普勒診斷明確、資料完整的合并PAH患者。結(jié)果：PAH組與非PAH組患有雷諾現(xiàn)象(42.1%vs13.5%)、指端血管炎(44.6% vs 10.6%)、活動后胸悶(32.5%vs17.3%)、肺間質(zhì)病變(69.9%vs14.4%)、SLEDAI評分(21.5±5.21vs12.7±6.39)相比較差異有統(tǒng)計(jì)學(xué)意義(P0.05)；兩組之間在年齡、性別、病史、關(guān)節(jié)炎、口腔潰瘍、光敏感、發(fā)熱等指標(biāo)相比較差異無統(tǒng)計(jì)學(xué)意義(P0.05)；結(jié)論：對于出現(xiàn)活動后胸悶、雷諾現(xiàn)象、指端血管炎和肺間質(zhì)病變的SLE患者應(yīng)警惕PAH的可能,心臟超聲多普勒及相關(guān)檢查有利于早期診斷。
[Abstract]:Objective: to analyze the clinical features of systemic lupus erythematosus (lupus) associated with pulmonary hypertension (lupus), and to discuss the etiology, clinical characteristics and prognostic factors of pulmonary hypertension (PAHs), so as to improve the understanding of PAHs secondary to systemic lupus erythematosus (SLE). Methods: from January 2008 to January 2014, a total of 187 SLE patients hospitalized in the Department of Dermatology and Rheumatological Immunology, first affiliated Hospital of Xinjiang Medical University, were analyzed retrospectively. PAH patients with complete data. Results there were significant differences in the Reynolds phenomenon between the two groups (44.1% vs 10.6%, 44.6% vs 10.6%), chest tightness after exercise (32.5 vs 17.33), interstitial lesion of lung (69.9 vs 14.4) and SLEDAI score of 21.5 鹵6.39 (P 0.05), age, sex, history of disease, arthritis, oral ulceration, ulcer, ulceration, etc. There was no significant difference in light sensitivity and fever (P 0.05). Conclusion: patients with SLE with active chest tightness, Raynaud phenomenon, phalanx vasculitis and pulmonary interstitial disease should be alert to the possibility of PAH. Doppler echocardiography and related examination are helpful for early diagnosis.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R593.241;R544.1
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本文編號：2046915