本文選題：性激素結(jié)合球蛋白 + 心血管疾病風險因子��； 參考：《復(fù)旦學報(醫(yī)學版)》2017年03期

【摘要】：目的探討社區(qū)老年人群中性激素結(jié)合球蛋白(sex hormone binding globulin,SHBG)與心血管疾病(cardiovascular disease,CVD)之間的相關(guān)性。方法于2014年選取上海市寶山區(qū)友誼社區(qū)1 916例老年人群(男796例、女1 120例),收集基礎(chǔ)的流行病學資料并采集空腹靜脈血進行檢測,計算得到10年Framingham風險積分。將肥胖、收縮壓、空腹血糖、脂類濃度及超敏C反應(yīng)蛋白作為心血管疾病風險因子,Framingham風險積分作為心血管疾病事件預(yù)測危險積分,分析SHBG與它們之間的相關(guān)性。結(jié)果存在心血管病史人群的SHBG均值低于不存在心血管病史人群(P0.001);男性SHBG與腰圍、臀圍、BMI指數(shù)、收縮壓、膽固醇、三酰甘油、高密度脂蛋白膽固醇、載脂蛋白A、超敏C反應(yīng)蛋白的相關(guān)系數(shù)分別為-0.312、-0.307、-0.266、-0.113、0.155、-0.277、0.510、0.394、-0.130(P0.01);女性SHBG與腰圍、臀圍、BMI指數(shù)、空腹血糖、膽固醇、三酰甘油、高密度脂蛋白膽固醇、載脂蛋白A和超敏C反應(yīng)蛋白的相關(guān)系數(shù)分別為-0.236、-0.248、-0.168、-0.183、0.135、-0.264、0.445、0.358、-0.295(P0.001);SHBG水平的降低與Framingham積分的升高存在一致性(κ=0.062,P0.001),且SHBG水平的升高會降低10年內(nèi)CVD的發(fā)病風險(P0.01)。結(jié)論該社區(qū)老年人群基線SHBG水平與CVD風險因子之間存在負相關(guān)性,與CVD保護因子之間存在正相關(guān)性,并且低水平SHBG預(yù)示著更高的CVD發(fā)病風險。
[Abstract]:Objective to investigate the relationship between sex hormone binding globulin (SHBG) and cardiovascular disease. Methods A total of 1 916 elderly people (796 males and 1 120 females) in Baoshan Friendship Community of Shanghai were selected in 2014. The basic epidemiological data were collected and fasting venous blood was collected for detection. Obesity, systolic blood pressure, fasting blood glucose, lipid concentration and hyper-sensitive C-reactive protein were used as risk factors for cardiovascular disease risk factor and the risk of cardiovascular events was predicted. The correlation between SHBG and SHBG was analyzed. Results the mean value of SHBG in the people with cardiovascular history was lower than that in those without cardiovascular history (P 0.001), the men's SHBG and waist circumference, hip circumference BMI index, systolic blood pressure, cholesterol, triglyceride, high density lipoprotein cholesterol, The correlation coefficients of apolipoprotein A and hypersensitive C-reactive protein were -0.312- 0.307U -0.266U -0.113n 0.155U -0.277U 0.510100.394U -0.130g P0.01.The correlation coefficient between SHBG and waist circumference, hip circumference BMI index, fasting blood glucose, cholesterol, triglyceride, high density lipoprotein cholesterol, female SHBG and waist circumference, hip circumference BMI index, fasting blood glucose, cholesterol, triacylglycerol, high density lipoprotein cholesterol, high density lipoprotein cholesterol, The correlation coefficients of apolipoprotein A and hypersensitive C-reactive protein were -0.236U -0.248U -0.168U -0.183U 0.135U -0.264U 0.445U 0.358U -0.295U P 0.001U, respectively. The decrease of SHBG level was consistent with the increase of Framus score (魏 0.062U P0.001N), and the increase of SHBG level decreased the risk of CVD within 10 years (P 0.01a). Conclusion there is a negative correlation between baseline SHBG levels and CVD risk factors and a positive correlation between baseline SHBG levels and CVD protection factors in this community.
【作者單位】： 上海市寶山區(qū)友誼街道社區(qū)衛(wèi)生服務(wù)中心檢驗科;復(fù)旦大學附屬中山醫(yī)院檢驗科;
【基金】：上海申康醫(yī)院發(fā)展中心課題(SHDC22014017) 上海市衛(wèi)生系統(tǒng)先進適宜推廣技術(shù)項目(2013SY065) 國家自然科學基金面上項目(81572064) 上海市衛(wèi)生計生系統(tǒng)重要薄弱學科建設(shè)項目(2015ZB0201) 上海市寶山區(qū)科學技術(shù)委員會科研項目(14-E-43)~~
【分類號】：R54
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本文編號：2032068